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Database: UniProt
Entry: U7P7J2_9GAMM
LinkDB: U7P7J2_9GAMM
Original site: U7P7J2_9GAMM 
ID   U7P7J2_9GAMM            Unreviewed;       487 AA.
AC   U7P7J2;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   05-JUL-2017, entry version 29.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=Q671_16105 {ECO:0000313|EMBL:ERS91543.1};
OS   Halomonas sp. PBN3.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=1397528 {ECO:0000313|EMBL:ERS91543.1, ECO:0000313|Proteomes:UP000017115};
RN   [1] {ECO:0000313|EMBL:ERS91543.1, ECO:0000313|Proteomes:UP000017115}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PBN3 {ECO:0000313|EMBL:ERS91543.1,
RC   ECO:0000313|Proteomes:UP000017115};
RX   PubMed=24356826;
RA   Overholt W.A., Green S.J., Marks K.P., Venkatraman R., Prakash O.,
RA   Kostka J.E.;
RT   "Draft genome sequences for oil-degrading bacterial strains from beach
RT   sands impacted by the deepwater horizon oil spill.";
RL   Genome Announc. 1:e01015-13(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ERS91543.1}.
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DR   EMBL; AXCA01000041; ERS91543.1; -; Genomic_DNA.
DR   RefSeq; WP_023004800.1; NZ_AXCA01000041.1.
DR   EnsemblBacteria; ERS91543; ERS91543; Q671_16105.
DR   PATRIC; fig|1397528.3.peg.636; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000017115; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017115};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017115}.
FT   DOMAIN      184    400       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      395    464       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     192    199       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
FT   COILED      457    484       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   487 AA;  54725 MW;  F271C256B07D8A40 CRC64;
     MSLALWQQCL DTLQDELSSQ QFNTWVRPLQ AEEGEAGELC LLAPNRFVRD WVSDKYAKRI
     AELLRELSPA RPPKVVLSVG SRRSAPRPQP RELGNPVSAA PRRPAAPAVH TPPRGDVADE
     KEISRQEEEA PRRPGGERQV QVEGSLKHNS GLNPNFTFET FVEGKSNQLA RAASRQVSEN
     PGGAYNPLFL YGGVGLGKTH LMHAVGNALA GRRENARVVY LHSERFVADM VKALQLNAIN
     DFKRFYRSVD ALLIDDIQFF AGKERSQEEF FHTFNALLEG GQQMILTSDR YPKEISGVEE
     RLKSRFGWGL TVAIEPPELE TRVAILMKKA DQAKVDLPHD AAFFIAQKIR SNVRELEGAL
     KKVIADSHFM GKPITQDFIR ESLKDLLALQ DKQVGVDNIQ RTVAEYYKIK LADLLSKRRS
     RSVARPRQVA MALAKELTNH SLPEIGDAFG GRDHTTVLHA CRKVQQLQEE NADIREDYKN
     LLRLLTS
//
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