ID U7PKX9_SPOS1 Unreviewed; 1321 AA.
AC U7PKX9;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=DNA repair protein REV1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=HMPREF1624_08087 {ECO:0000313|EMBL:ERS95571.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS95571.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
CC -!- SIMILARITY: Belongs to the DNA polymerase type-Y family.
CC {ECO:0000256|ARBA:ARBA00010945}.
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DR EMBL; KI440853; ERS95571.1; -; Genomic_DNA.
DR AlphaFoldDB; U7PKX9; -.
DR STRING; 1391915.U7PKX9; -.
DR eggNOG; KOG2093; Eukaryota.
DR HOGENOM; CLU_003901_1_1_1; -.
DR OrthoDB; 169741at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003684; F:damaged DNA binding; IEA:InterPro.
DR GO; GO:0016740; F:transferase activity; IEA:UniProtKB-KW.
DR GO; GO:0070987; P:error-free translesion synthesis; IEA:UniProt.
DR CDD; cd17719; BRCT_Rev1; 1.
DR CDD; cd01701; PolY_Rev1; 1.
DR Gene3D; 3.30.70.270; -; 1.
DR Gene3D; 3.40.1170.60; -; 1.
DR Gene3D; 6.10.250.1490; -; 1.
DR Gene3D; 6.10.250.1630; -; 2.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.50.10190; BRCT domain; 1.
DR Gene3D; 3.30.1490.100; DNA polymerase, Y-family, little finger domain; 1.
DR Gene3D; 1.20.58.1280; DNA repair protein Rev1, C-terminal domain; 1.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR036775; DNA_pol_Y-fam_lit_finger_sf.
DR InterPro; IPR017961; DNA_pol_Y-fam_little_finger.
DR InterPro; IPR025527; HUWE1/Rev1_UBM.
DR InterPro; IPR031991; Rev1_C.
DR InterPro; IPR038401; Rev1_C_sf.
DR InterPro; IPR043128; Rev_trsase/Diguanyl_cyclase.
DR InterPro; IPR001126; UmuC.
DR PANTHER; PTHR45990; DNA REPAIR PROTEIN REV1; 1.
DR PANTHER; PTHR45990:SF1; DNA REPAIR PROTEIN REV1; 1.
DR Pfam; PF00533; BRCT; 1.
DR Pfam; PF00817; IMS; 1.
DR Pfam; PF11799; IMS_C; 1.
DR Pfam; PF16727; REV1_C; 1.
DR Pfam; PF14377; UBM; 3.
DR SMART; SM00292; BRCT; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF100879; Lesion bypass DNA polymerase (Y-family), little finger domain; 1.
DR PROSITE; PS50172; BRCT; 1.
DR PROSITE; PS50173; UMUC; 1.
PE 3: Inferred from homology;
KW DNA synthesis {ECO:0000256|ARBA:ARBA00022634};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 62..150
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 434..632
FT /note="UmuC"
FT /evidence="ECO:0000259|PROSITE:PS50173"
FT REGION 216..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 294..357
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 809..892
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 928..981
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1000..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1055..1101
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1152..1175
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..232
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 933..959
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1321 AA; 143144 MW; 3D0A7AF43FD4E1B1 CRC64;
MANRQLDKNA AAVRKQIASR KFEGEDGEEY GASRFGEFGD YFRRKKLKLQ NEDTIMRQAV
QGKPQIFKDV TAHVASYTQP PSEELRRLLV LHGGVYVKYL DYKTMVSHIV ASTLPPKKAD
EWRRLRVVRP AWILDSIAAG RMLPWSDYRL INDGPGQTRI QLDGRKMAVQ AGRPDQMAGY
REQSKDSYYA SQMQRLAASH ERAGTTTRSI FEQLETTMEG EDGEDGEDGG DGGDGEGHEH
DVPNFGIDSD PLSSLEKEKG KGKADGVAAG SPFDARHLLE DVDVNDTYME GIEQEPTAES
DPVAEPEPEA EPYQDLPPGQ GMMKMDDADD ASDKHMAALQ ASSPSKPPRD APGKPMTSEE
HNALLLADPK LRKASSANPD FLKQFYAESR LHHLSTWKAE LKSKMQRLAA DKDKGRRATA
PTAAPRSKTT RRYVMHVDFD SFFCAVSLKS APAYVDKPAA VAHSAGRAAE IASCNYPART
FGVKNGMWMR RALELCPDLK VLPYDFPAYE EASALFYEAL LALGDGSVVQ SVSVDEALVD
ITRLVVGDDQ GDTSDPTVLA REQDAADALA ATLRRQIKES TGCDVSVGIG GNILLAKVAL
RRAKPAGQYQ LRPAAVLDVL GDLAVEQLPG VAYSIGGKLD EMGVRLVRDL RALSKDRLVT
VLGPKTGERL YAYARGIDAA AVGDQPVRKS VSAEVNWGIR FVHQDEAEEF VLNLCRELER
RLLNEQVKGR ALTMKILRRA SDAPLDPEKH LGHGKCDVFN KSVVFGVATH DAERIAKEAV
SILRSFHFSP GDLRGLGVQL QKLEPIGGGG GGGGGLDAAA RDSSQKKLSF GNAGVASGAP
RPASSRPAVQ HQTADKPKPL RKSIFTTPVA PLVSRGHNTM EDGPRQADGA PPSMALASTQ
FFIPANPDPS VLAELPPDII RRLVGERPQE VEHSGAGNNS NSNSNSNSNS NSRNLSPVKR
ESRGPSPAPS GVDDLPPDID PEVFEALPAD MRAEVLAEYR RHARQPSHSP APSPRRGNKT
KAVHAPGHGS GHAAKKGSPV KRGIWGTRGL AAAAAARERR HDAQANRVQT SIFVPRPPPE
DADADADAGA GTDSNGDDGL EAFDPEVLAA LPDDVREEVL EDYRRRQQAQ QAQQPQPLHA
PQALRLEIPA HRSRSDAPPA AAQQPTGAAS TALEKRPLLL QQPPSGFKRP MLQFPAPPPK
MGFRASSSDH AQEAPVVLSL ADTKAMLKTW HSATRDEGPH DTDVEVLERY LAGVVTQECD
MEKARKLVVW LAWLVDDGEA VADDDDDAGT VGRQSWQFAL GRVKEAVQAA MQARGLGPLQ
F
//
