ID U7PL05_SPOS1 Unreviewed; 232 AA.
AC U7PL05;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ERS96257.1};
GN Name=GET1 {ECO:0000256|HAMAP-Rule:MF_03113};
GN ORFNames=HMPREF1624_07166 {ECO:0000313|EMBL:ERS96257.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS96257.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the WRB/GET1 family.
CC {ECO:0000256|ARBA:ARBA00010799, ECO:0000256|HAMAP-Rule:MF_03113}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|HAMAP-Rule:MF_03113}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI440850; ERS96257.1; -; Genomic_DNA.
DR AlphaFoldDB; U7PL05; -.
DR STRING; 1391915.U7PL05; -.
DR eggNOG; KOG4253; Eukaryota.
DR HOGENOM; CLU_089418_1_0_1; -.
DR OrthoDB; 1421963at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043529; C:GET complex; IEA:InterPro.
DR GO; GO:0071816; P:tail-anchored membrane protein insertion into ER membrane; IEA:InterPro.
DR Gene3D; 1.10.287.660; Helix hairpin bin; 1.
DR HAMAP; MF_03113; Get1; 1.
DR InterPro; IPR028945; Get1.
DR InterPro; IPR027538; Get1_fungi.
DR InterPro; IPR029012; Helix_hairpin_bin_sf.
DR PANTHER; PTHR42650:SF1; GUIDED ENTRY OF TAIL-ANCHORED PROTEINS FACTOR 1; 1.
DR PANTHER; PTHR42650; TAIL-ANCHORED PROTEIN INSERTION RECEPTOR WRB; 1.
DR Pfam; PF04420; CHD5; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|HAMAP-Rule:MF_03113};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824, ECO:0000256|HAMAP-
KW Rule:MF_03113};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_03113};
KW Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_03113};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_03113};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_03113}.
FT SIGNAL 1..20
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 21..232
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004685489"
FT TOPO_DOM 1..4
FT /note="Lumenal"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03113"
FT TOPO_DOM 173..232
FT /note="Cytoplasmic"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03113"
FT REGION 188..232
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 71..98
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03113"
SQ SEQUENCE 232 AA; 25813 MW; CDAE16277155DED0 CRC64;
MPSLLLVVFL VELAVQVVNS LGAATIADFL WRIYNIVPSK QSAAVAAQRK AQTEYLALRR
ELHATSSQDE FAKWARLRRQ HDKKLEELEA KKKSLDTGRR SFDTAVTVLR LALTRGLQFL
LPFWYAREPM FWLPHGWFPG YAEWLVAFPR APRGSVSITS WQLACTGVLV LVKDTLVALV
ALVQEARDTT PPSQEKETTS TKQKEAAVAA EGASSKDTSS ETKAARAGKD EL
//
