ID U7PME6_SPOS1 Unreviewed; 621 AA.
AC U7PME6;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=U2 snRNP auxiliary factor large subunit {ECO:0000256|ARBA:ARBA00030821};
GN ORFNames=HMPREF1624_07637 {ECO:0000313|EMBL:ERS96101.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS96101.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR EMBL; KI440851; ERS96101.1; -; Genomic_DNA.
DR AlphaFoldDB; U7PME6; -.
DR STRING; 1391915.U7PME6; -.
DR eggNOG; KOG0120; Eukaryota.
DR HOGENOM; CLU_021795_2_0_1; -.
DR OrthoDB; 101932at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0006397; P:mRNA processing; IEA:InterPro.
DR CDD; cd12231; RRM2_U2AF65; 1.
DR CDD; cd12232; RRM3_U2AF65; 1.
DR Gene3D; 3.30.70.330; -; 3.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR000504; RRM_dom.
DR InterPro; IPR003954; RRM_dom_euk.
DR InterPro; IPR006529; U2AF_lg.
DR NCBIfam; TIGR01642; U2AF_lg; 1.
DR PANTHER; PTHR23139; RNA-BINDING PROTEIN; 1.
DR PANTHER; PTHR23139:SF9; SPLICING FACTOR U2AF 65 KDA SUBUNIT; 1.
DR Pfam; PF00076; RRM_1; 2.
DR SMART; SM00360; RRM; 2.
DR SMART; SM00361; RRM_1; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 2.
DR PROSITE; PS50102; RRM; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884, ECO:0000256|PROSITE-
KW ProRule:PRU00176}.
FT DOMAIN 413..491
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT DOMAIN 528..613
FT /note="RRM"
FT /evidence="ECO:0000259|PROSITE:PS50102"
FT REGION 1..220
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..87
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 94..216
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 621 AA; 68524 MW; A25EAF9CF54BC8C6 CRC64;
MNGEGHSREG GRHGSSRGER ERGDRGDRDE RRDHGRSERE RGDRPRRRSR SPDHRGARGS
RREAREPREP REPREPREAR DSREGGGAEP DSYSSSRSHR DREREDRYSG GRGGDRRERD
PWGGGGDRDR ERERDRDRDR DRDRDRDRRR RGRGGGGGDD DDDDRHNRRR RGDRGDRDDR
ERRRSASPPP KKREPTPDLT DVTSVLERKR RLTQWDMKPP GYESVTAEQA KLSGMFPLPG
APRQQQQMDP SKLQAFIAQP AATASNNAAT ASVLKPTNSR QAKRLLAANL PAGTSEDALV
SFFNLQLNGL NVIDGSDPCV QAQLSSDASF ALLEFRDAAD ATVALALDGI TMEAEDTAMT
DGGEAAANNA NGAAQKAKGL QLSRPKDYIV PAVVDYSGYQ PGVVSTVVVD TPNKISITNI
PPYLTDEQVT ELLVAFGELR AFVLAKDRSS DESRGIAFCE YAEPASTEIA IQGLHGMDLG
DRKLRVQKAS VGIAQAAGME LGVNAMSMLA GTVAVDATDV SRVVQLLNMV TADELVDNED
YEEIRDDVRE ECEKFGTVTG LKVPRPAGGS RQSAGVGKIF VKFETPDMAT KALKALAGRK
FSDRTVIATY FPEENFEVDA W
//