ID   U7PRT5_SPOS1            Unreviewed;      1328 AA.
AC   U7PRT5;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=5-oxoprolinase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=HMPREF1624_05096 {ECO:0000313|EMBL:ERS98312.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS98312.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SIMILARITY: Belongs to the oxoprolinase family.
CC       {ECO:0000256|ARBA:ARBA00010403}.
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DR   EMBL; KI440846; ERS98312.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7PRT5; -.
DR   STRING; 1391915.U7PRT5; -.
DR   eggNOG; KOG1939; Eukaryota.
DR   HOGENOM; CLU_002157_0_0_1; -.
DR   OrthoDB; 674at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR   InterPro; IPR049517; ACX-like_C.
DR   InterPro; IPR008040; Hydant_A_N.
DR   InterPro; IPR002821; Hydantoinase_A.
DR   InterPro; IPR003692; Hydantoinase_B.
DR   InterPro; IPR045079; Oxoprolinase_fam.
DR   PANTHER; PTHR11365:SF2; 5-OXOPROLINASE; 1.
DR   PANTHER; PTHR11365; 5-OXOPROLINASE RELATED; 1.
DR   Pfam; PF19278; Hydant_A_C; 1.
DR   Pfam; PF05378; Hydant_A_N; 1.
DR   Pfam; PF01968; Hydantoinase_A; 1.
DR   Pfam; PF02538; Hydantoinase_B; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087}.
FT   DOMAIN          6..218
FT                   /note="Hydantoinase/oxoprolinase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF05378"
FT   DOMAIN          237..536
FT                   /note="Hydantoinase A/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF01968"
FT   DOMAIN          552..731
FT                   /note="Acetophenone carboxylase-like C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF19278"
FT   DOMAIN          752..1284
FT                   /note="Hydantoinase B/oxoprolinase"
FT                   /evidence="ECO:0000259|Pfam:PF02538"
SQ   SEQUENCE   1328 AA;  141554 MW;  DDB1177315CCAEC3 CRC64;
     MKGIQIAIDR GGTFTDVHAI VPGRPDDIVI KLLSVDPQNY PDAPTEGIRR VLEQALGQPV
     PRGQPIDVSA VASIRMGTTV ATNALLERKG ERSALLITKG FRDLLVIGNQ ARPDIFDLTV
     AKPGVLYEKV VEIDERVTLE GFTEDPEKTV IDPASDPALV VGLSKEVVRV MTKPDLAAVR
     TVIQGLYDEG FRSLSVCFMH SYTFPDHELA VARIAEDMGM SVSVSSLLQP MIKMVPRGQS
     ATADAYLTPL IKKYLDSFRR GFVGELEDAS TTRCDVMQSD GGLVSFRKFS GLRAILSGPA
     GGVVGYAQTS YDPRSAKPII GFDMGGTSTD VSRYAGSYEH IFETTTAGIA LQTPQLDINT
     VAAGGGSRLF WSNGLFKVGP ESAGAHPGPA CYRKGGPLTV TDANLFLGRL VPEYFPKIFG
     KNEDQPLDVE VTRTLFEEMK AEVNSGLPVG TAKLTAEEVA LGFLRVANES MCRPIRTLTE
     ARGHDAAHHD LAVFGGAGGQ HACSIAAALG IRRVVLHRFS SILSAYGMAL ADIVADVQAP
     LACVFSEDNL PQIKATAAEL RVKAEAELLD QGLAVNDTRA EYELFLHMHY EGSDTLIMIP
     QAAGADHEWA FADTFIERHR QEFGFTMPRD VFVGDVRIRA VGKSSAGASA TVAAQEMERV
     ARGPASASAV QMAKPVYFEG GLGWKQTPVY LLTSLREGEQ VAGPAMIIDN TQTIVVAPNA
     VATALAEHVV VDIDVAGTRQ QGPAAAGGPV LDPVQLSVFG HRFMGIAEQM GRTLQKTSVS
     TNIKERLDFS CALFSEDGKL VANAPHVPVH LGSMQYAVLW QHEHWKGQLK EGDVLVSNHP
     ICGGTHLPDI TVITPFFENG KIVFYVASRG HHADIGGISA GSLPPNSTEL WQEGAAIESV
     KLVEGGAFNE AAMREHLLVR PAQYPGCSGA RNLSDNLADL RAQTGANQKG IHLIGQLVKE
     YGLETVLFYM RAIQDNAEIA VRRLLKETFT RFGGRPMEAT EFMDDGSPIK LKITIDGDAG
     TADFDFTGTG PEVYGSTNAP TSVTYSAIIY VLRCLVKEDI PLNQGCLTPI NVIMPPRTIL
     SPSAEAAVVG GNCVTSQRVT DVILRCFDVC AASQGCLNNL TFGKSSRLDA DTGTYTPGYG
     YYETIAGGAG AGPGWHGTDG VHVHMTNTRI TDAEIFERRY PCLVREFSLR QGSGGAGAFR
     GGEGCVRDIE FRQPLSAAIL SDRRVHPPYG MRGGQPGAVG VNLFIKTMPN GEDRVINLGP
     KNSIQAAVGD RMVILTPGGG GWGHAADAAD PGGAGYSNGG SSVVAGGGAP FVRGTGSVAA
     FQSMQNSN
//