ID U7PUA5_SPOS1 Unreviewed; 992 AA.
AC U7PUA5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Pep3/Vps18/deep orange beta-propeller domain-containing protein {ECO:0000259|Pfam:PF05131};
GN ORFNames=HMPREF1624_04828 {ECO:0000313|EMBL:ERS98050.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS98050.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004287};
CC Peripheral membrane protein {ECO:0000256|ARBA:ARBA00004287};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004287}.
CC -!- SIMILARITY: Belongs to the VPS18 family.
CC {ECO:0000256|ARBA:ARBA00010454}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI440846; ERS98050.1; -; Genomic_DNA.
DR AlphaFoldDB; U7PUA5; -.
DR STRING; 1391915.U7PUA5; -.
DR eggNOG; KOG2034; Eukaryota.
DR HOGENOM; CLU_003488_0_0_1; -.
DR OrthoDB; 22879at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006886; P:intracellular protein transport; IEA:UniProtKB-UniRule.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd16462; RING-H2_Pep3p-like; 1.
DR InterPro; IPR000547; Clathrin_H-chain/VPS_repeat.
DR InterPro; IPR007810; Pep3_Vps18.
DR PANTHER; PTHR23323; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN; 1.
DR PANTHER; PTHR23323:SF26; VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 18 HOMOLOG; 1.
DR Pfam; PF05131; Pep3_Vps18; 1.
DR SUPFAM; SSF75011; 3-carboxy-cis,cis-mucoante lactonizing enzyme; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50236; CHCR; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 22..459
FT /note="Pep3/Vps18/deep orange beta-propeller"
FT /evidence="ECO:0000259|Pfam:PF05131"
FT REGION 241..285
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 840..867
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 241..277
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 992 AA; 109858 MW; 0CF391675F29D5CD CRC64;
MALDPSSAFS ATSGLADDNG LPIFDVQRVQ MQFSIAANFV AAQVANNVLV LALSNGRILR
IDLNRPEDID DIDLPKRPSE IGVIERLFLD PTASHLVICT SAGECYYLHS QSRQPKPLAR
LRGVPIQSIA WNPLLPTAST REILIGAADG NIYESFLEPS NDFYRKEDKY IKSLARLPDG
AITGLWADAI PSRSDQFRRV LVSTSSRLLH WVGKIGRAQD GGGSVYTKLF EAEQPVIHDL
ASTSSGGVAS TASTTASSSS APGSSLSTST TSLVVSPDPE TGRPYEAVSP DRAFAWLSSH
GVYHGKLLVA PPKPELGTNV FAESKLIPRS QLVAGSDASS AGRRRVTNDP VDTIALTQWH
VISLVAGRIV AANRLTGSVV YDQVILDPGQ KAISLSVDLQ KSTFWLFTAK EIFEIVVRDE
DRDIWKIMLQ LQQFDAAMQY AHNPAQRDAV ATASGDYLIG KGLFDEAAGI YGKSSKPFED
VALALIDRNQ PDALRKYLLT KLSTYKKPGV MQRVMIASWL VEIFMAKLNS LDDTIVTKAE
LSETLDPAQT REQLELVRDE FKAFARKHKA DLDRKTVYDI ISSHGREEEL LFFADAINDY
NYVLSYWVQR EKWSEALAVL KRQTDADAFY RYSSVLMTHV ATELVDVLMR QGNSINPRSM
IPALLDYDSS FKGPLAQNQA IRYLQYVINQ LHSTDAAVHN TIVSMYASLP SRDEAALLSY
LESQGDEPRF DPDFALRLCI QYKRVLSCVH IYTSMGQYVQ AVDLALSHDA VELASVVADR
PMDNTALRKK LWLAVARKVI SQQSNGGIKA AIDFLKRCDL LKIEDLIPFF PDFVVIDDFK
EEICAALEDY SREIDGLKKE MDDSSQTAAN IKVDIAALDH RYAIVEPGEK CYVCGLPLLS
RQFFVFPCQH AFHSDCLGRR VLEQSSHGVG RKIRDLQVQI TKGLVTGPKK DAMVAELDAL
VASACILCSD FAIKKISEPF IRPDENKNEW VL
//