ID U7PV06_SPOS1 Unreviewed; 1243 AA.
AC U7PV06;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 25.
DE RecName: Full=PXA domain-containing protein {ECO:0000259|PROSITE:PS51207};
GN ORFNames=HMPREF1624_04658 {ECO:0000313|EMBL:ERS99458.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS99458.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
CC -!- SIMILARITY: Belongs to the sorting nexin family.
CC {ECO:0000256|ARBA:ARBA00010883}.
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DR EMBL; KI440845; ERS99458.1; -; Genomic_DNA.
DR AlphaFoldDB; U7PV06; -.
DR STRING; 1391915.U7PV06; -.
DR eggNOG; ENOG502RM76; Eukaryota.
DR HOGENOM; CLU_007315_0_0_1; -.
DR OrthoDB; 2727031at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0035091; F:phosphatidylinositol binding; IEA:InterPro.
DR CDD; cd06093; PX_domain; 1.
DR Gene3D; 3.30.1520.10; Phox-like domain; 1.
DR InterPro; IPR003114; Phox_assoc.
DR InterPro; IPR036871; PX_dom_sf.
DR InterPro; IPR013937; Sorting_nexin_C.
DR PANTHER; PTHR22775:SF47; MEIOTICALLY UP-REGULATED GENE 122 PROTEIN; 1.
DR PANTHER; PTHR22775; SORTING NEXIN; 1.
DR Pfam; PF08628; Nexin_C; 1.
DR Pfam; PF02194; PXA; 1.
DR SMART; SM00313; PXA; 1.
DR SUPFAM; SSF64268; PX domain; 1.
DR PROSITE; PS51207; PXA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 111..132
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 197..395
FT /note="PXA"
FT /evidence="ECO:0000259|PROSITE:PS51207"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 412..435
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 539..667
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 841..1009
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1022..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 14..34
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 412..431
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 552..634
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 637..654
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 841..922
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 957..1009
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1058
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1243 AA; 132412 MW; 1FE997EE90A1E6A2 CRC64;
MDDRKISVND PDRDLSLDSA SPTFAASSSP SGLSPVSSPP LPQRPNLASQ SLSAPPSPLP
NSPQSPSPNT KPGSTASDDD IPTRIFRFLS TATVESLSAV GVGLAATTYF VLGRVGLVLI
GAFGGIALFV AWEARNPDVT RAIRGEASSD LLARVIEYRR KDQENGDEVS GESVGAEAAF
DPAQEDLALG RAFENFRPET RQALNGLVEA VVRDYVKWWY QPIVPSDQSF PLSCRRVLTS
FLVSVSNHLS RKRPADAFLD FLTNSTSIVI VLFSELATAF AEHAAQTPQQ QGSAPPQGPD
ANPTISAADA IYSYLASNPN SNLANLLSQR QQASKFRMVA DDLLSFLDRQ CYDCDPARTF
LREIAATSVL ETTLQTCSKP EWINGWIVHL LEGGEPDFSQ AIDVGMQTRT DAAATASSSK
DATSNSATAH MHHASIDIDG NVGNIALPKS RRSSFEADKA HQSRRKESVP LSHKKQLSRA
DEEMEEAMEE MKRMNEMIAA EEKARRTTTE TKSATEAEDR LADAMQHNAD ELGIQANDER
KDHHGHGPPS PSAASDQISP KASLSLSGDE STTRTARTVS TPITPRSSTQ GSPSQSSFAK
SEAASGTAAN GSENTENPHP STADEASQFT SFDQLVPPAR EEDESSDSEG RKKQEQAPPP
LTLHNANVTI HDEPVTDKGR IKSRPAWDFL IQIEPANAHY PGWMIVRKYA DFEKLHEVLR
RIATISGATA FTEQHGVLPN WKIHTRGSLR GELERYVRDA CWYQPLAESE GMKRFLEKDT
NNMPAASKTG LNAFETMGKN MLDALSNAPK GVAEGGKVMV GGVTGVFGNL GNLGTNIGLG
GSSGQKKQHA SSGSLANVAG SPSPGGATTS PPASVLQDVT AYTNRLSVST PPRMDSGFSG
AGSRRSRDSM DSQRSSVVAS QTGRVVPMGR RMSYQSQSGL MDAGANGEVG EAGADGRGRT
NNNNSNNMWG DYAPVSSGSR GSQHNSRASS SGGYPRSPSS TSLSGTRLPM GATSAFATDA
LEDMPGSSLT SPVRVGSSNN LTSLPAGGAG SGSGATTPHG TRPLHRVATS GTTIAKQFAA
LTEGETRVAV ELLFAVINEL YTLSSAWNIR RTLLTAAKSF LLRPGNPSLA SIQSLLQSSV
LDANTTDAGM AGYLNTLREN TMPTDAERAA WPAEMTAEEK ERLRVKARRL LIRSGVPAAL
MGVMGQSATS DALGRIFDCL QVEEVARGLI FGLMLQAARI VTH
//
