ID   U7PX17_SPOS1            Unreviewed;       581 AA.
AC   U7PX17;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Choline-sulfatase {ECO:0000313|EMBL:ERS99294.1};
GN   ORFNames=HMPREF1624_04493 {ECO:0000313|EMBL:ERS99294.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERS99294.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
CC   -!- SIMILARITY: Belongs to the sulfatase family.
CC       {ECO:0000256|ARBA:ARBA00008779}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KI440845; ERS99294.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7PX17; -.
DR   STRING; 1391915.U7PX17; -.
DR   eggNOG; KOG3867; Eukaryota.
DR   HOGENOM; CLU_006332_9_1_1; -.
DR   OrthoDB; 5488719at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   CDD; cd16032; choline-sulfatase; 1.
DR   Gene3D; 3.40.720.10; Alkaline Phosphatase, subunit A; 1.
DR   InterPro; IPR017850; Alkaline_phosphatase_core_sf.
DR   InterPro; IPR017785; Choline-sulfatase.
DR   InterPro; IPR025863; Choline_sulf_C_dom.
DR   InterPro; IPR024607; Sulfatase_CS.
DR   InterPro; IPR000917; Sulfatase_N.
DR   NCBIfam; TIGR03417; chol_sulfatase; 1.
DR   PANTHER; PTHR45953; IDURONATE 2-SULFATASE; 1.
DR   PANTHER; PTHR45953:SF1; IDURONATE 2-SULFATASE; 1.
DR   Pfam; PF12411; Choline_sulf_C; 1.
DR   Pfam; PF00884; Sulfatase; 1.
DR   SUPFAM; SSF53649; Alkaline phosphatase-like; 1.
DR   PROSITE; PS00523; SULFATASE_1; 1.
DR   PROSITE; PS00149; SULFATASE_2; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087}.
FT   DOMAIN          42..401
FT                   /note="Sulfatase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF00884"
FT   DOMAIN          518..569
FT                   /note="Choline sulfatase enzyme C-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF12411"
FT   REGION          1..40
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        13..34
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   581 AA;  65045 MW;  1ABB7867DDA1AE08 CRC64;
     MAPDLNSMPA SPAVGATAPS TSAPVASSTG PQAPPKPTRK QPNILYVMAD QLAAPQLKMY
     NPNSQIITPN LDALAAKSVQ FDSAYCPSPL CAPSRMSMIT GRLPMGIGAY DNGAQIGSDI
     PTYAHYLRLQ GYHTVLAGKM HFIGDQLHGY ETRLTSDIYP GDFGWVVNWD KPDTRLEWYH
     NASSIEQAGV CVRSNQLDYD NEVMYRSEQY LYDYVRADPS TRRPFCLTVS LTHPHDPYTI
     HRKFWDMYEG VDIDMPKVNI PKEDQDPHSK RLLKVCDLWD KEFTDEQVKR AKRAYYGAVS
     YVDDCLGRLL GILKDCDLAD DTIVIFSGDH GDMLGERGLW YKMSYFESSV RVPFLIHHPP
     GIGVNGGEGQ EANANSIKPH RVSQNVSTLD ILPTMCDLTG ATPHPDLPMD GQSLLPHLQN
     RDGGPDTVIA EYTGEGTVAP LMMIRRGAYK FVICPSDGVQ LFNLQTDPDE LIDLAKALQK
     KAELGTVLTA EEEVARQVLT AFEAEAAERW DMDAITKAVR QSQRQRQLVW PALKTGKFTS
     WDYDPHDDGR EKYIRSHMDL DDLERMARFP PVDRWGKDAR T
//