ID   U7Q235_SPOS1            Unreviewed;       834 AA.
AC   U7Q235;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=Partial AB-hydrolase lipase domain-containing protein {ECO:0000259|Pfam:PF04083};
GN   ORFNames=HMPREF1624_00188 {ECO:0000313|EMBL:ERT01893.1};
OS   Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS   disease fungus).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC   Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX   NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERT01893.1, ECO:0000313|Proteomes:UP000018087};
RN   [1] {ECO:0000313|Proteomes:UP000018087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 58251 / de Perez 2211183
RC   {ECO:0000313|Proteomes:UP000018087};
RX   PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA   Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA   Goldberg J., Young S., Zeng Q., Birren B.W.;
RT   "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT   58251).";
RL   Genome Announc. 2:E0044614-E0044614(2014).
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DR   EMBL; KI440842; ERT01893.1; -; Genomic_DNA.
DR   AlphaFoldDB; U7Q235; -.
DR   STRING; 1391915.U7Q235; -.
DR   eggNOG; KOG2624; Eukaryota.
DR   HOGENOM; CLU_024238_0_0_1; -.
DR   OrthoDB; 5471104at2759; -.
DR   Proteomes; UP000018087; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR006693; AB_hydrolase_lipase.
DR   PANTHER; PTHR11005; LYSOSOMAL ACID LIPASE-RELATED; 1.
DR   PANTHER; PTHR11005:SF160; STEROL ESTERASE 1-RELATED; 1.
DR   Pfam; PF04083; Abhydro_lipase; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000018087};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        220..243
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          322..419
FT                   /note="Partial AB-hydrolase lipase"
FT                   /evidence="ECO:0000259|Pfam:PF04083"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          117..191
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          274..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          808..834
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        174..188
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..297
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        645..667
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   834 AA;  93328 MW;  75270AF3E069D1AA CRC64;
     MVSEKPRPDG GPPAQQQQKG DSNDDAHSPL LLDETLAQTA VEFVKQSEKL SLQKSDNEPP
     GQSREMAVEA RFVTPQDPVI VTADGNRLPP VPLSEAHKLN ILKDELQGKA QILDEKASAN
     KAARPEKATS SNQPPNGAPD QPGPASSSEK LLDIGQKERQ KKAKRAKQRF ASPMQRSAEG
     TLQRAMPPSH TNPLFPPLPL YGPPSILRNL QSTTFRVTSF FLSLSFLGVI VLGSLFTSIP
     GAFRRMACRL TLRDPDANRP LYAEEKRRAK LRHDLDRNWR RQQRRQRQRR DSSEDEDPAG
     AGVGDATYTP TAGGPDPLVP DVAHYARRVG LDVEAFEVQT EDGFLIDLWH IVDPNEDTPR
     PAEARKHRGP GLLFDETTKE ERAATEQAML NEPRTNNKRP KFPVLLVHGL LQSAGAYCVG
     DDDSLAFYLC KAGYDVWLGN NRCGFQPRHT VLHPSDPRMW CWNIRQMGVF DLPALASRVL
     RETRFAHLGL VCHSQGTTEA LVALAKEQRP DLGEALTVFC ALAPAVYAGR LIGKMYFKFM
     RVISPAMFRI MFGIHSFIPL MMQVHPLLPG RLYGWLGYRV FSFLFEWTDA RWDRGLRDRM
     FQFSPVYVSA ESMRWWLGRE GFARHKCILA TKEEWRREEA EADAAAEANE ADEADESDET
     SPAEDENEDD ALGNRVPGSS AWYDERVPPF ALWVCGRDDL VDGRRLLRRF LPRPVFAALE
     RGQGSCSTSS GTQRSLREPH VRVVHAKVIP EYEHLDVIWA IDAVDEVFGE VRDVLWKTCN
     VRNSCRVPRG CETVEAWDDP ARQWRLKSDG GGMNDEDTMD GAAVGNSGTA TAGT
//