ID U7Q3V8_SPOS1 Unreviewed; 1676 AA.
AC U7Q3V8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 31.
DE RecName: Full=DH domain-containing protein {ECO:0000259|PROSITE:PS50010};
GN ORFNames=HMPREF1624_00822 {ECO:0000313|EMBL:ERT02523.1};
OS Sporothrix schenckii (strain ATCC 58251 / de Perez 2211183) (Rose-picker's
OS disease fungus).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Sordariomycetidae; Ophiostomatales; Ophiostomataceae; Sporothrix.
OX NCBI_TaxID=1391915 {ECO:0000313|EMBL:ERT02523.1, ECO:0000313|Proteomes:UP000018087};
RN [1] {ECO:0000313|Proteomes:UP000018087}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 58251 / de Perez 2211183
RC {ECO:0000313|Proteomes:UP000018087};
RX PubMed=24855299; DOI=10.1128/genomea.00446-14;
RA Cuomo C.A., Rodriguez-Del Valle N., Perez-Sanchez L., Abouelleil A.,
RA Goldberg J., Young S., Zeng Q., Birren B.W.;
RT "Genome sequence of the pathogenic fungus Sporothrix schenckii (ATCC
RT 58251).";
RL Genome Announc. 2:E0044614-E0044614(2014).
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DR EMBL; KI440842; ERT02523.1; -; Genomic_DNA.
DR AlphaFoldDB; U7Q3V8; -.
DR STRING; 1391915.U7Q3V8; -.
DR eggNOG; ENOG502QVFV; Eukaryota.
DR HOGENOM; CLU_004333_0_0_1; -.
DR OrthoDB; 24699at2759; -.
DR Proteomes; UP000018087; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF275; LD03170P; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR PROSITE; PS50010; DH_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000018087}.
FT DOMAIN 256..485
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 879..927
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1166..1305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1320..1510
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 1632..1676
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 879..911
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1166..1189
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1199..1227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1257..1275
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1363..1411
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1419..1438
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1454..1468
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1469..1492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1493..1510
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1676 AA; 183647 MW; D6AE940D7C312F0F CRC64;
MVRVTDELAI SPETIALYHA SDPLLGHLPV LAFHGPSTTA NFTHNSSRIQ VHIYSPAGFQ
SFPRLTVSPS SDFYSVVTHL PREFQGDEIC RGLAFSLFKY FSELPESVKT YLRNQYPTTR
GRRPGSAPAL FGEQHAADLA KAMACVETNI DEHLRALECA LQTQHVSNID LDLVLPPGAI
RLPSLDGDGA SGAVEDDDDD VILDPTLRQY DPAYTPLVKL FGEPVFLPTS KLRRAPSRPS
SLNHRTKAFT KDQKVELRMQ MGELVDTEER YVLKLNELVK HIADDFRQKA KDRTASSSSP
SMEDVDRLFP RSADHILQVN SAFMQDLRRV MDDTEEDAVR DLDIPYTFGS ASSRTMLVSS
HAPSGGGSVR VKDPSGALAM AKTFLEWFPK FTDCYQDYIR ASQNFPQLLS SFLDNNQSSF
RDRVVQTTGE QALRSILIEP VQRLPRYSLF IDQIVGCLPI THPALQLMLK ARDIITNICS
MDDPSDNKPH VVNRLRNLVE CWPMDLEPRG RLVLAADFVE LAAPYDADAH SIGIQDRAGL
FLLFSDCLVV VKKKAGTTFT GRDLLREIDK PSPAGLLVSM TNAAGGPGTY DFAFSGWHRL
ADVCFTESAD SRLVWMTSTQ EMKSAHSGDY MASKAITSRC FVLQETFEAK AMRWSEDLVK
ARIEGRFSEA ERETPTWSLR SVRLPENNNM GLHAAVFQEA AEELIEGRRE PAPVRVVFDN
HLGTKGAPVG HYGVEIVVEV RTDVGRSSTG SRGSYSNGEK RLIMNTVGLN GKRYSDDIAQ
DDFLPTLARR IIQLMSSQYN PSNPKLVPAL VSYHTKTLRS LKFGNRAEKT KSFLGSSPVK
LLSSFLSGGS TTNVASNNAS PAVAAVANTS TTTLSETIHG SMRLQRSQSS SSRPPQPPQA
DTASLSGSIR DRTGGATFGG DASRPENPLV RLEQTFTGYV AALQARKGQF VARTLLGRSS
SSADELSVNL LYNRLNESPY DWESSSDLMP EVVFAAFEKF TRIAWRDQMG TIMTIQSLDA
LQERAIRKVP GDFADFVNYL FGDMAPQNRR AFTALIKLLA DLLDGCSDDG DRGALTLAFA
ELLVAGNGDP HNYINLLDLL VQDCDRIFDE IGLGSGIHLR SSAYESFNSS VARSHKSATG
SLTSNTSSLR RKFGLESLLR QNSSSNRGLE NMVSGASGLA DSTSERPSMW RSLSKHHRNP
ATGESSSLSK ATSASYVNRS RSIDMGNHSP MGMNKLMRRP ASRDRPPIAG AFDDLSMMQR
PTSSHRPTSS HKQLETIGEP DTEPGVGTSG KSVTEKSLKK KRRSSLSDLK SLMAVVSLDD
DDVQPSPVSK NNDSPLPPIP LRTTKITSEK VNAGPRAPSP SKIPKSPQSL SQTQFQSHGR
QNSTQAQQIQ APPQLASMFQ SPTQKENIAA GDSPQQPVYE PGHSKTLSSG SHIPTLKTSR
AAGTILPPPG SISPTRQSHL PPPSPSKLTP GTLASANNGS TLGGTGQKLR LQSPQKLRER
LQSEKRAVEE VDASLQSELS LISENMAKLN RAGPPPPSTS TGPAPGTTTV DLRTLAAAVQ
ALEARLPKRL QEVSDRQEAL QRDMDATVKA SEGKVRAIDQ MYKEATAENE LLYEKFNTEL
GKIVRALKGK GREDKEELVA KLKEQTEETA RLKKDNARLR REAVSLRALL KSEQQS
//
