ID U7UII4_9FIRM Unreviewed; 280 AA.
AC U7UII4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE SubName: Full=Putative organophosphate reductase {ECO:0000313|EMBL:ERT59227.1};
GN ORFNames=HMPREF1250_1487 {ECO:0000313|EMBL:ERT59227.1};
OS Megasphaera vaginalis.
OC Bacteria; Bacillota; Negativicutes; Veillonellales; Veillonellaceae;
OC Megasphaera.
OX NCBI_TaxID=1111454 {ECO:0000313|EMBL:ERT59227.1, ECO:0000313|Proteomes:UP000017090};
RN [1] {ECO:0000313|EMBL:ERT59227.1, ECO:0000313|Proteomes:UP000017090}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BV3C16-1 {ECO:0000313|EMBL:ERT59227.1,
RC ECO:0000313|Proteomes:UP000017090};
RA Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA Methe B., Sutton G., Nelson K.E.;
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERT59227.1}.
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DR EMBL; AWXA01000037; ERT59227.1; -; Genomic_DNA.
DR RefSeq; WP_023053854.1; NZ_AWXA01000037.1.
DR AlphaFoldDB; U7UII4; -.
DR STRING; 1111454.HMPREF1250_1487; -.
DR PATRIC; fig|1111454.3.peg.1406; -.
DR eggNOG; COG0656; Bacteria.
DR OrthoDB; 9804790at2; -.
DR Proteomes; UP000017090; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0071704; P:organic substance metabolic process; IEA:UniProt.
DR GO; GO:0044281; P:small molecule metabolic process; IEA:UniProt.
DR Gene3D; 3.20.20.100; NADP-dependent oxidoreductase domain; 1.
DR InterPro; IPR020471; AKR.
DR InterPro; IPR018170; Aldo/ket_reductase_CS.
DR InterPro; IPR023210; NADP_OxRdtase_dom.
DR InterPro; IPR036812; NADP_OxRdtase_dom_sf.
DR PANTHER; PTHR43827; 2,5-DIKETO-D-GLUCONIC ACID REDUCTASE; 1.
DR PANTHER; PTHR43827:SF3; ALDO-KETO REDUCTASE; 1.
DR Pfam; PF00248; Aldo_ket_red; 1.
DR PIRSF; PIRSF000097; AKR; 2.
DR PRINTS; PR00069; ALDKETRDTASE.
DR SUPFAM; SSF51430; NAD(P)-linked oxidoreductase; 1.
DR PROSITE; PS00798; ALDOKETO_REDUCTASE_1; 1.
DR PROSITE; PS00062; ALDOKETO_REDUCTASE_2; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000017090}.
FT DOMAIN 25..258
FT /note="NADP-dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF00248"
FT ACT_SITE 49
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-1"
FT BINDING 107
FT /ligand="substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-2"
FT SITE 74
FT /note="Lowers pKa of active site Tyr"
FT /evidence="ECO:0000256|PIRSR:PIRSR000097-3"
SQ SEQUENCE 280 AA; 31576 MW; 3697C1A1A8AAF35A CRC64;
METITLYNGV VMPLVGLGTF KIDDAAAGEA NIIDAIHCGY RLLDTAQAYG NEEIVGKAVK
RSGVDRHELF LTTKIWYRSF ESPDCEKSVE ASLRKLGTDY LDLLLLHWPY GNIYNAWRTL
EKLYQAGTVR AIGVSNFMES QLLDLLEFND VAPAVDQVET HLRCQYPSLH ALLRERGIAH
QAYSPFGRFK DPTMFTAPAI TAISEKYGKT PQQIALRFFT QDGISVVPKS MRRERLLANK
DLFDISLTDE EMTALRQMNS DLYLIGNSQD GAFTKAFFAR
//
