ID   U7UU31_9FIRM            Unreviewed;       530 AA.
AC   U7UU31;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 42.
DE   SubName: Full=Cardiolipin synthetase {ECO:0000313|EMBL:ERT62825.1};
DE            EC=2.7.8.- {ECO:0000313|EMBL:ERT62825.1};
GN   Name=cls {ECO:0000313|EMBL:ERT62825.1};
GN   ORFNames=HMPREF1252_1044 {ECO:0000313|EMBL:ERT62825.1};
OS   Peptoniphilus sp. BV3AC2.
OC   Bacteria; Bacillota; Tissierellia; Tissierellales; Peptoniphilaceae;
OC   Peptoniphilus.
OX   NCBI_TaxID=1111133 {ECO:0000313|EMBL:ERT62825.1, ECO:0000313|Proteomes:UP000017087};
RN   [1] {ECO:0000313|EMBL:ERT62825.1, ECO:0000313|Proteomes:UP000017087}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BV3AC2 {ECO:0000313|EMBL:ERT62825.1,
RC   ECO:0000313|Proteomes:UP000017087};
RA   Durkin A.S., Haft D.R., McCorrison J., Torralba M., Gillis M., Haft D.H.,
RA   Methe B., Sutton G., Nelson K.E.;
RL   Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ERT62825.1}.
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DR   EMBL; AWXD01000031; ERT62825.1; -; Genomic_DNA.
DR   RefSeq; WP_023060140.1; NZ_AWXD01000031.1.
DR   AlphaFoldDB; U7UU31; -.
DR   PATRIC; fig|1111133.4.peg.1638; -.
DR   Proteomes; UP000017087; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   GO; GO:0008808; F:cardiolipin synthase activity; IEA:InterPro.
DR   GO; GO:0032049; P:cardiolipin biosynthetic process; IEA:InterPro.
DR   CDD; cd09160; PLDc_SMU_988_like_2; 1.
DR   Gene3D; 3.30.870.10; Endonuclease Chain A; 2.
DR   InterPro; IPR022924; Cardiolipin_synthase.
DR   InterPro; IPR027379; CLS_N.
DR   InterPro; IPR025202; PLD-like_dom.
DR   InterPro; IPR001736; PLipase_D/transphosphatidylase.
DR   NCBIfam; TIGR04265; bac_cardiolipin; 1.
DR   PANTHER; PTHR21248; CARDIOLIPIN SYNTHASE; 1.
DR   PANTHER; PTHR21248:SF22; PHOSPHOLIPASE D; 1.
DR   Pfam; PF13091; PLDc_2; 2.
DR   Pfam; PF13396; PLDc_N; 1.
DR   SMART; SM00155; PLDc; 2.
DR   SUPFAM; SSF56024; Phospholipase D/nuclease; 2.
DR   PROSITE; PS50035; PLD; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Phospholipid biosynthesis {ECO:0000256|ARBA:ARBA00023209};
KW   Phospholipid metabolism {ECO:0000256|ARBA:ARBA00023264};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ERT62825.1};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        32..51
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        57..77
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        89..107
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          264..291
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
FT   DOMAIN          443..470
FT                   /note="PLD phosphodiesterase"
FT                   /evidence="ECO:0000259|PROSITE:PS50035"
SQ   SEQUENCE   530 AA;  61466 MW;  B0A11794A74204FF CRC64;
     MGKIISKKKK ENLKKKYEEW AKILSKKYKD RPMILIIVLV LIQLALLFVI YTKFKSYLKY
     FTPAMTIITI AMITHIIDKD MNPAFKISWM APISVFPAFG TMLYLFLHTF PGNKLGINSL
     KENIKKTKPY LFQNKDHLGE MEEYASEFKG LADYVHKMGP YPVYKNTKVD YYEDTVEGFE
     ALFSAMRQAK EFIFAEYFIL KPGKILDEFV SILEEKVKEG VEVRFMFDAI SMFNLPKNFE
     EELKSKGIKV KIFAPVSPFL STYQNNRDHR KVLVIDNDLA FSGGVNLADE YANLIEVYGH
     WKDNVIRIRG EAVKSMTAIF LQMWNIFADG KEDYDKYLAP RDGFFPNSDE YVIPYADAPG
     DGESLAKNVY LYMSYEAKKY IHIMTPYLVL DNEVLTALTF AAKRGIDVKI IMPHIPDKKI
     PFAVARSYYK DLIPEGVKIY EYTPGFVHSK VVIIDGEATT VSTVNMDFRS MYLNFENGIF
     IHGKETTESV EEDFQNTLSV SQRIDIEYYQ SFPRKYRFFG AFMRIFGPLM
//