ID U7V5Y1_9MICC Unreviewed; 228 AA.
AC U7V5Y1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=dihydrofolate reductase {ECO:0000256|ARBA:ARBA00012856};
DE EC=1.5.1.3 {ECO:0000256|ARBA:ARBA00012856};
GN ORFNames=HMPREF0742_00528 {ECO:0000313|EMBL:ERT67117.1};
OS Rothia aeria F0184.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Rothia.
OX NCBI_TaxID=888019 {ECO:0000313|EMBL:ERT67117.1, ECO:0000313|Proteomes:UP000017174};
RN [1] {ECO:0000313|EMBL:ERT67117.1, ECO:0000313|Proteomes:UP000017174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0184 {ECO:0000313|EMBL:ERT67117.1,
RC ECO:0000313|Proteomes:UP000017174};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Cofactor biosynthesis; tetrahydrofolate biosynthesis; 5,6,7,8-
CC tetrahydrofolate from 7,8-dihydrofolate: step 1/1.
CC {ECO:0000256|ARBA:ARBA00004903}.
CC -!- SIMILARITY: Belongs to the dihydrofolate reductase family.
CC {ECO:0000256|ARBA:ARBA00009539}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERT67117.1}.
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DR EMBL; AXZG01000015; ERT67117.1; -; Genomic_DNA.
DR RefSeq; WP_023133178.1; NZ_KI518043.1.
DR AlphaFoldDB; U7V5Y1; -.
DR PATRIC; fig|888019.4.peg.450; -.
DR HOGENOM; CLU_043966_5_0_11; -.
DR UniPathway; UPA00077; UER00158.
DR Proteomes; UP000017174; Unassembled WGS sequence.
DR GO; GO:0004146; F:dihydrofolate reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0006545; P:glycine biosynthetic process; IEA:InterPro.
DR GO; GO:0046654; P:tetrahydrofolate biosynthetic process; IEA:UniProtKB-UniPathway.
DR CDD; cd00209; DHFR; 1.
DR Gene3D; 3.40.430.10; Dihydrofolate Reductase, subunit A; 1.
DR InterPro; IPR012259; DHFR.
DR InterPro; IPR024072; DHFR-like_dom_sf.
DR InterPro; IPR001796; DHFR_dom.
DR PANTHER; PTHR48069; DIHYDROFOLATE REDUCTASE; 1.
DR PANTHER; PTHR48069:SF3; DIHYDROFOLATE REDUCTASE; 1.
DR Pfam; PF00186; DHFR_1; 1.
DR PRINTS; PR00070; DHFR.
DR SUPFAM; SSF53597; Dihydrofolate reductase-like; 1.
DR PROSITE; PS51330; DHFR_2; 1.
PE 3: Inferred from homology;
KW One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563}.
FT DOMAIN 13..227
FT /note="DHFR"
FT /evidence="ECO:0000259|PROSITE:PS51330"
SQ SEQUENCE 228 AA; 25182 MW; 0C263EA614C16CBD CRC64;
MREYDSPSPV RPCLGAIWAQ TDAGIIGRDG TMPWRAPEDL AHFKTVTVGK PVILGRRTWE
SFPPRFRPLP ERTNIVISRS ITSDSAAPLK RDGALWVPSL DAALTLADNT PLTPNTTQRS
DAAHQRVTAW IIGGGSVYAE ALSREDLPSF GRVEIIERTL FYCQEGNEIT GDTYAPELAV
EGFVTAGEPA RWRILGESAW EKSERGYLLD ASGGKNPMYY SFQTLARL
//