ID U7V7A2_9MICC Unreviewed; 660 AA.
AC U7V7A2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=DNA (Cytosine-5-)-methyltransferase {ECO:0000313|EMBL:ERT67435.1};
GN ORFNames=HMPREF0742_00340 {ECO:0000313|EMBL:ERT67435.1};
OS Rothia aeria F0184.
OC Bacteria; Actinomycetota; Actinomycetes; Micrococcales; Micrococcaceae;
OC Rothia.
OX NCBI_TaxID=888019 {ECO:0000313|EMBL:ERT67435.1, ECO:0000313|Proteomes:UP000017174};
RN [1] {ECO:0000313|EMBL:ERT67435.1, ECO:0000313|Proteomes:UP000017174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F0184 {ECO:0000313|EMBL:ERT67435.1,
RC ECO:0000313|Proteomes:UP000017174};
RA Weinstock G., Sodergren E., Wylie T., Fulton L., Fulton R., Fronick C.,
RA O'Laughlin M., Godfrey J., Miner T., Herter B., Appelbaum E., Cordes M.,
RA Lek S., Wollam A., Pepin K.H., Palsikar V.B., Mitreva M., Wilson R.K.;
RL Submitted (AUG-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the N(4)/N(6)-methyltransferase family.
CC {ECO:0000256|ARBA:ARBA00006594}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ERT67435.1}.
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DR EMBL; AXZG01000010; ERT67435.1; -; Genomic_DNA.
DR RefSeq; WP_023133026.1; NZ_KI518035.1.
DR AlphaFoldDB; U7V7A2; -.
DR PATRIC; fig|888019.4.peg.290; -.
DR HOGENOM; CLU_020164_1_1_11; -.
DR Proteomes; UP000017174; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR002941; DNA_methylase_N4/N6.
DR InterPro; IPR002052; DNA_methylase_N6_adenine_CS.
DR InterPro; IPR002295; N4/N6-MTase_EcoPI_Mod-like.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR13370; RNA METHYLASE-RELATED; 1.
DR PANTHER; PTHR13370:SF16; TYPE III RESTRICTION-MODIFICATION ENZYME STYLTI MOD SUBUNIT; 1.
DR Pfam; PF01555; N6_N4_Mtase; 1.
DR PRINTS; PR00506; D21N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS00092; N6_MTASE; 1.
PE 3: Inferred from homology;
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603,
KW ECO:0000313|EMBL:ERT67435.1};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ERT67435.1}.
FT DOMAIN 66..439
FT /note="DNA methylase N-4/N-6"
FT /evidence="ECO:0000259|Pfam:PF01555"
SQ SEQUENCE 660 AA; 74111 MW; 12F254A3F0C2AE97 CRC64;
MPELTWIGKN KVVTHHLDVP YRVLEKQYTY GKNADGTDVS SSENMVIHGD NLEALKSLLP
MYEGRVDCIY IDPPYNTGNE SWVYNDNVKD PQILKWLGEV VGKEGEDLSR HDKWLCMMYP
RLRLLQRLLA PTGAIFISID DNEAAHLRLI CNEIFGARCF VADISWQRTY SPRNDSKGIP
AEVEHLLVFS KEPGWQPRKL ERTAEADTKY KNPDNDYGPW TSGDAFAPGA STHQGMVYAV
QHPFTGDLIY PPASNCWRYS QERLFPIFSE WTEYELRDID DAEKRAEICG ISPEDVRPGV
KALMLAKPLE VAQAEAKEVY DRGAWPRFYF TNGGKGGVRR KTYLDSVGGL LPSNFWEHQA
AGNTDIAKKE IRAIFDRRVA FDTPKPTRLV ERVLAIATDS DSIVLDSFAG SGTTAHAVLN
ANAKDRGNRK FILVELGDYA ETVTAERVRR VIDGYVETTA EESVLFDQKI NLASLKKGSQ
VFEEANAVAV NAAQNGAYTK VSKPKLYTEV TGKNNASVSL RVTATVEHEK KAAGVPGSFA
YYELGAPLFV QDGLNSEVPY EKMAEYIWYS ETSTPLDPRG YNEAHKLHPH YLGKYDDTSY
FFAYDPESAT SLDRKYLGTI PTECAAGSYV IYAETCLLDE KDLLSHNITF KKIARDISRV
//
