ID UBFL6_HUMAN Reviewed; 400 AA.
AC P0CB48;
DT 03-NOV-2009, integrated into UniProtKB/Swiss-Prot.
DT 03-NOV-2009, sequence version 1.
DT 13-SEP-2023, entry version 55.
DE RecName: Full=Putative upstream-binding factor 1-like protein 6;
GN Name=UBTFL6;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.
CC -!- CAUTION: Could be the product of a pseudogene. {ECO:0000305}.
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DR EMBL; AC017099; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; P0CB48; -.
DR SMR; P0CB48; -.
DR IntAct; P0CB48; 1.
DR iPTMnet; P0CB48; -.
DR PhosphoSitePlus; P0CB48; -.
DR BioMuta; HGNC:35406; -.
DR DMDM; 263545823; -.
DR MassIVE; P0CB48; -.
DR PeptideAtlas; P0CB48; -.
DR AGR; HGNC:35406; -.
DR GeneCards; UBTFL6; -.
DR HGNC; HGNC:35406; UBTFL6.
DR neXtProt; NX_P0CB48; -.
DR PharmGKB; PA164727481; -.
DR InParanoid; P0CB48; -.
DR PhylomeDB; P0CB48; -.
DR PathwayCommons; P0CB48; -.
DR SignaLink; P0CB48; -.
DR Pharos; P0CB48; Tdark.
DR Proteomes; UP000005640; Unplaced.
DR RNAct; P0CB48; Protein.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001164; F:RNA polymerase I core promoter sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0001181; F:RNA polymerase I general transcription initiation factor activity; IBA:GO_Central.
DR GO; GO:0045943; P:positive regulation of transcription by RNA polymerase I; IBA:GO_Central.
DR GO; GO:0006360; P:transcription by RNA polymerase I; IBA:GO_Central.
DR CDD; cd21998; HMG-box_UBF1_rpt1-like; 1.
DR CDD; cd22003; HMG-box_UBF1_rpt6-like; 1.
DR Gene3D; 1.10.30.10; High mobility group box domain; 2.
DR InterPro; IPR009071; HMG_box_dom.
DR InterPro; IPR036910; HMG_box_dom_sf.
DR PANTHER; PTHR46318; UPSTREAM BINDING TRANSCRIPTION FACTOR; 1.
DR PANTHER; PTHR46318:SF1; UPSTREAM-BINDING FACTOR 1-LIKE PROTEIN 1-RELATED; 1.
DR Pfam; PF00505; HMG_box; 1.
DR SMART; SM00398; HMG; 2.
DR SUPFAM; SSF47095; HMG-box; 2.
DR PROSITE; PS50118; HMG_BOX_2; 2.
PE 5: Uncertain;
KW DNA-binding; Nucleus; Reference proteome; Repeat.
FT CHAIN 1..400
FT /note="Putative upstream-binding factor 1-like protein 6"
FT /id="PRO_0000386642"
FT DNA_BIND 107..175
FT /note="HMG box 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT DNA_BIND 229..295
FT /note="HMG box 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00267"
FT REGION 320..400
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 327..341
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..367
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..384
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 400 AA; 46551 MW; 1D48696B3717993F CRC64;
MPAKDIKVAL PRSQGHWSNA DILRLLECME NNLPYDDNGT FSSTQSHMDW GKVAFKNFSG
EMCRLKWLEI SCSLRKFSTL KKLVLEAKKC VKNTNKSQKG RNHPDFPKRL LTAYIRFFKE
NWPQYSQMYP GMRSQEVTKI LSKKYKELPE QMKQKHIQDF RKEKQEFEEK LARFREEHPD
LDQKGKKSDI CKRVQTKVQK KVQKNIEEVR SLPKTDQFFK KVKFHGEPQK PPMNGYQKFH
QDSWSSKELQ HLSLRERMVE IGRRWQRIPQ SQKDHYKSQA ELLQKEYKVE LDLWLKTLSP
EDYAAYKEST YAKGKNMAMM GGPAPSLKQT DPQSSSAKGL QEGFGEGQGL QAAGTEASQT
IWVNCQVSME PEDNRKKDGE EEESSNSLDC SSGEDMEVDV
//
