UniProt: UBQLN

Database: UniProt
Entry: UBQLN_MOUSE

LinkDB:  UBQLN_MOUSE 
Original site:  UBQLN_MOUSE

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Ontology (3)   
   GO (3)   
Gene (6)   
   KEGG GENES (1)   
   NCBI-Gene (1)   
   ENSEMBL-UP (3)   
   MGI-MMU (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (4)   
   EMBL (4)   
3D Structure (1)   
   PDB (1)   
Protein domain (8)   
   InterPro (4)   
   Pfam (1)   
   PROSITE (2)   
   SMART (1)   
Literature (3)   
   PubMed (3)   
All databases (26)   

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ID   UBQLN_MOUSE             Reviewed;         610 AA.
AC   Q14DL0; E9QM12; Q14DR8; Q8BVT0;
DT   23-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT   27-JUL-2011, sequence version 2.
DT   24-JAN-2024, entry version 107.
DE   RecName: Full=Ubiquilin-like protein;
GN   Name=Ubqlnl;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=C57BL/6J; TISSUE=Testis;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [4]
RP   STRUCTURE BY NMR OF 556-609.
RG   RIKEN structural genomics initiative (RSGI);
RT   "Solution structure of RSGI RUH-056, a UBA domain from mouse cDNA.";
RL   Submitted (OCT-2006) to the PDB data bank.
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DR   EMBL; AK076645; BAC36434.1; -; mRNA.
DR   EMBL; AC123830; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC111901; AAI11902.1; -; mRNA.
DR   EMBL; BC113134; AAI13135.1; -; mRNA.
DR   CCDS; CCDS21611.1; -.
DR   RefSeq; NP_941026.2; NM_198624.3.
DR   PDB; 2DNA; NMR; -; A=557-610.
DR   PDBsum; 2DNA; -.
DR   AlphaFoldDB; Q14DL0; -.
DR   SMR; Q14DL0; -.
DR   STRING; 10090.ENSMUSP00000056365; -.
DR   iPTMnet; Q14DL0; -.
DR   PhosphoSitePlus; Q14DL0; -.
DR   PaxDb; 10090-ENSMUSP00000056365; -.
DR   ProteomicsDB; 297796; -.
DR   Antibodypedia; 23640; 95 antibodies from 20 providers.
DR   DNASU; 244179; -.
DR   Ensembl; ENSMUST00000059121.5; ENSMUSP00000056365.5; ENSMUSG00000051437.5.
DR   GeneID; 244179; -.
DR   KEGG; mmu:244179; -.
DR   UCSC; uc009ivl.1; mouse.
DR   AGR; MGI:2685336; -.
DR   CTD; 143630; -.
DR   MGI; MGI:2685336; Ubqlnl.
DR   VEuPathDB; HostDB:ENSMUSG00000051437; -.
DR   eggNOG; KOG0010; Eukaryota.
DR   GeneTree; ENSGT00940000163345; -.
DR   HOGENOM; CLU_024293_4_0_1; -.
DR   InParanoid; Q14DL0; -.
DR   OMA; LSAHFKC; -.
DR   OrthoDB; 5491123at2759; -.
DR   PhylomeDB; Q14DL0; -.
DR   TreeFam; TF314412; -.
DR   BioGRID-ORCS; 244179; 2 hits in 78 CRISPR screens.
DR   EvolutionaryTrace; Q14DL0; -.
DR   PRO; PR:Q14DL0; -.
DR   Proteomes; UP000000589; Chromosome 7.
DR   RNAct; Q14DL0; Protein.
DR   Bgee; ENSMUSG00000051437; Expressed in seminiferous tubule of testis and 3 other cell types or tissues.
DR   Genevisible; Q14DL0; MM.
DR   GO; GO:0005829; C:cytosol; IBA:GO_Central.
DR   GO; GO:0031593; F:polyubiquitin modification-dependent protein binding; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   CDD; cd14399; UBA_PLICs; 1.
DR   Gene3D; 1.10.8.10; DNA helicase RuvA subunit, C-terminal domain; 1.
DR   InterPro; IPR009060; UBA-like_sf.
DR   InterPro; IPR015496; Ubiquilin.
DR   InterPro; IPR000626; Ubiquitin-like_dom.
DR   InterPro; IPR029071; Ubiquitin-like_domsf.
DR   PANTHER; PTHR10677; UBIQUILIN; 1.
DR   PANTHER; PTHR10677:SF9; UBIQUILIN-LIKE PROTEIN; 1.
DR   Pfam; PF00240; ubiquitin; 1.
DR   SMART; SM00213; UBQ; 1.
DR   SUPFAM; SSF46934; UBA-like; 1.
DR   SUPFAM; SSF54236; Ubiquitin-like; 1.
DR   PROSITE; PS50053; UBIQUITIN_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Reference proteome.
FT   CHAIN           1..610
FT                   /note="Ubiquilin-like protein"
FT                   /id="PRO_0000307792"
FT   DOMAIN          31..105
FT                   /note="Ubiquitin-like"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00214"
FT   DOMAIN          562..607
FT                   /note="UBA"
FT   CONFLICT        17
FT                   /note="T -> P (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        52
FT                   /note="V -> G (in Ref. 1; BAC36434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        58
FT                   /note="I -> M (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        82
FT                   /note="H -> Y (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        132
FT                   /note="S -> C (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        142
FT                   /note="N -> S (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        145
FT                   /note="K -> I (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        150
FT                   /note="Missing (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        163
FT                   /note="S -> G (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        196
FT                   /note="P -> Q (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        256
FT                   /note="F -> Y (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        284
FT                   /note="V -> A (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        345
FT                   /note="P -> S (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        383
FT                   /note="S -> P (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        387
FT                   /note="K -> E (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        395
FT                   /note="T -> A (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        423
FT                   /note="G -> R (in Ref. 3; AAI13135)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        445
FT                   /note="S -> P (in Ref. 3; AAI11902/AAI13135)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        460
FT                   /note="Q -> H (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        517
FT                   /note="S -> G (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        522
FT                   /note="V -> E (in Ref. 1; BAC36434)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        553
FT                   /note="P -> L (in Ref. 3; AAI11902)"
FT                   /evidence="ECO:0000305"
FT   HELIX           564..567
FT                   /evidence="ECO:0007829|PDB:2DNA"
FT   HELIX           569..578
FT                   /evidence="ECO:0007829|PDB:2DNA"
FT   HELIX           583..592
FT                   /evidence="ECO:0007829|PDB:2DNA"
FT   HELIX           597..606
FT                   /evidence="ECO:0007829|PDB:2DNA"
SQ   SEQUENCE   610 AA;  67566 MW;  48F57D85DA7CF840 CRC64;
     MPRIISRSPK MPQSRYTAGV PADGKISPGV IRVIVKTPGN QIIFTVADDT LVRQFKEILS
     AHFKCQMEQL VLVFMGRLLK DHDTLSQRGI TDGHIIHVVI KSKHGPRSLA HSFRNLVTNN
     PCHQDRNPKG NSSMVCQSAG MNETKVESSL LMEPEAPKVG TESPEVGSLE HIAQVLENLC
     VQSLLSNMDF VHQMPPEQPY MEELIQQNPE VSHLLDNSEI LCQTLELVRH LAIIQEIMQI
     QQPAQNPEYP PNSQPFLGLE TVPNGNNHLG QSYVNNNDHM LNGVPDLLEG NCFTALLDEQ
     VLEQVQTPSL SQPLPQEQWD QLSSSQVIYA NSCGLSSITP TNATPNHTNN VSRENPAIVA
     TQGQSNVCAV QQPAEIPVLP TISINQKPQV DKDTTITLGI SDQWLEEDLQ QSDDQTSSQI
     TGGMIQLLRN HPQMAAQMLL LMNTSQLNEQ WRQETPTPLQ SSQLHDLLLA LANPKTSQAL
     LQIEHGLQLL ATEAPALLPY IEPYLWGLGW LIPSICSYPD IVPWTWNVQD MAEPQCPESC
     HKSETVLQKV QPPSGDPSHS LQAPEVRFSK EMECLQAMGF VNYNANLQAL IATDGDTNAA
     IYKLKSSQGF
//

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