ID UVRC_NOSP7 Reviewed; 625 AA.
AC B2J6D3;
DT 24-MAR-2009, integrated into UniProtKB/Swiss-Prot.
DT 10-JUN-2008, sequence version 1.
DT 27-MAR-2024, entry version 81.
DE RecName: Full=UvrABC system protein C {ECO:0000255|HAMAP-Rule:MF_00203};
DE Short=Protein UvrC {ECO:0000255|HAMAP-Rule:MF_00203};
DE AltName: Full=Excinuclease ABC subunit C {ECO:0000255|HAMAP-Rule:MF_00203};
GN Name=uvrC {ECO:0000255|HAMAP-Rule:MF_00203}; OrderedLocusNames=Npun_R3957;
OS Nostoc punctiforme (strain ATCC 29133 / PCC 73102).
OC Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Nostocaceae; Nostoc.
OX NCBI_TaxID=63737;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ATCC 29133 / PCC 73102;
RX PubMed=23463784; DOI=10.1104/pp.112.213116;
RA Ekman M., Picossi S., Campbell E.L., Meeks J.C., Flores E.;
RT "A Nostoc punctiforme Sugar Transporter Necessary to Establish a
RT Cyanobacterium-Plant Symbiosis.";
RL Plant Physiol. 161:1984-1992(2013).
CC -!- FUNCTION: The UvrABC repair system catalyzes the recognition and
CC processing of DNA lesions. UvrC both incises the 5' and 3' sides of the
CC lesion. The N-terminal half is responsible for the 3' incision and the
CC C-terminal half is responsible for the 5' incision. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
CC -!- SUBUNIT: Interacts with UvrB in an incision complex.
CC {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000255|HAMAP-Rule:MF_00203}.
CC -!- SIMILARITY: Belongs to the UvrC family. {ECO:0000255|HAMAP-
CC Rule:MF_00203}.
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DR EMBL; CP001037; ACC82338.1; -; Genomic_DNA.
DR RefSeq; WP_012410306.1; NC_010628.1.
DR AlphaFoldDB; B2J6D3; -.
DR SMR; B2J6D3; -.
DR STRING; 63737.Npun_R3957; -.
DR EnsemblBacteria; ACC82338; ACC82338; Npun_R3957.
DR KEGG; npu:Npun_R3957; -.
DR eggNOG; COG0322; Bacteria.
DR HOGENOM; CLU_014841_3_2_3; -.
DR OrthoDB; 9804933at2; -.
DR PhylomeDB; B2J6D3; -.
DR Proteomes; UP000001191; Chromosome.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0009380; C:excinuclease repair complex; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009381; F:excinuclease ABC activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006289; P:nucleotide-excision repair; IEA:UniProtKB-UniRule.
DR GO; GO:0009432; P:SOS response; IEA:UniProtKB-UniRule.
DR CDD; cd10434; GIY-YIG_UvrC_Cho; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 3.40.1440.10; GIY-YIG endonuclease; 1.
DR Gene3D; 4.10.860.10; UVR domain; 1.
DR Gene3D; 3.30.420.340; UvrC, RNAse H endonuclease domain; 1.
DR HAMAP; MF_00203; UvrC; 1.
DR InterPro; IPR041663; DisA/LigA_HHH.
DR InterPro; IPR000305; GIY-YIG_endonuc.
DR InterPro; IPR035901; GIY-YIG_endonuc_sf.
DR InterPro; IPR047296; GIY-YIG_UvrC_Cho.
DR InterPro; IPR003583; Hlx-hairpin-Hlx_DNA-bd_motif.
DR InterPro; IPR010994; RuvA_2-like.
DR InterPro; IPR001943; UVR_dom.
DR InterPro; IPR036876; UVR_dom_sf.
DR InterPro; IPR004791; UvrC.
DR InterPro; IPR001162; UvrC_RNase_H_dom.
DR InterPro; IPR038476; UvrC_RNase_H_dom_sf.
DR NCBIfam; TIGR00194; uvrC; 1.
DR PANTHER; PTHR30562:SF1; UVRABC SYSTEM PROTEIN C; 1.
DR PANTHER; PTHR30562; UVRC/OXIDOREDUCTASE; 1.
DR Pfam; PF01541; GIY-YIG; 1.
DR Pfam; PF12826; HHH_2; 1.
DR Pfam; PF02151; UVR; 1.
DR Pfam; PF08459; UvrC_RNaseH_dom; 1.
DR SMART; SM00465; GIYc; 1.
DR SMART; SM00278; HhH1; 2.
DR SUPFAM; SSF46600; C-terminal UvrC-binding domain of UvrB; 1.
DR SUPFAM; SSF82771; GIY-YIG endonuclease; 1.
DR SUPFAM; SSF47781; RuvA domain 2-like; 1.
DR PROSITE; PS50164; GIY_YIG; 1.
DR PROSITE; PS50151; UVR; 1.
DR PROSITE; PS50165; UVRC; 1.
PE 3: Inferred from homology;
KW Cytoplasm; DNA damage; DNA excision; DNA repair; Excision nuclease;
KW Reference proteome; SOS response.
FT CHAIN 1..625
FT /note="UvrABC system protein C"
FT /id="PRO_1000099503"
FT DOMAIN 26..105
FT /note="GIY-YIG"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
FT DOMAIN 215..250
FT /note="UVR"
FT /evidence="ECO:0000255|HAMAP-Rule:MF_00203"
SQ SEQUENCE 625 AA; 71580 MW; 42677F8E0317D710 CRC64;
MTISTQILPL VKEPERLENR LAEIPPEPGV YFMRDNSDRI IYIGKSRKLR SRVRSYFRDG
YNKTERIATM VKLVTEIEFI VTDTEAEALA LEANLIKQHQ PYFNVLLKDD KKYPYLCITW
SEDYPRIFIT RKRQLGKEKD KFYGPYTDAG LLREIVRICK RIFPQRQRPQ PLFKDRPCLN
YDLGRCPGVC QKLTSPEEYR KIVQKIAMVF QGRTQELIDI LTQQMNAAAE NLNFESAARI
RDQISGLKSL TADQKVSLPD DTVSRDAIAL AANEEHACIQ LFQIRAGQLV GRLAFVADAH
AELGAILQRA LEEHYQTADS VEIPLEILVQ HDLPDSDILA DVLTQRKGKK VTILTPLRQT
KAELIEMVER NAQYELQRMQ KFGDRNHQAM QDLAAILDLP DVPHRIEGYD ISHIQGSNAV
ASQVVFIDGL PAKQHYRHYK IKNPTVTAGH SDDFASLAEV IQRRFRKYAE DPQLSRLGNP
DWPDLIMIDG GKGQLSSVTA VLQEMNLLED LRVVSLAKQR EEIFLPGESK PSSTDAEQPG
VQLLRRLRDE AHRFAVSFHR QQRSDKLKRS RLDEIPGLGH HRQKQLLGHF RSVDYIRQAT
TPQLAEVPGI GPRLAQEIYD YFHPA
//
