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Database: UniProt
Entry: V2QH49_9BACT
LinkDB: V2QH49_9BACT
Original site: V2QH49_9BACT 
ID   V2QH49_9BACT            Unreviewed;       454 AA.
AC   V2QH49;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   25-OCT-2017, entry version 30.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=N508_00805 {ECO:0000313|EMBL:ESJ98589.1};
OS   Mucispirillum schaedleri ASF457.
OC   Bacteria; Deferribacteres; Deferribacterales; Deferribacteraceae;
OC   Mucispirillum.
OX   NCBI_TaxID=1379858 {ECO:0000313|EMBL:ESJ98589.1, ECO:0000313|Proteomes:UP000017429};
RN   [1] {ECO:0000313|EMBL:ESJ98589.1, ECO:0000313|Proteomes:UP000017429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ASF457 {ECO:0000313|EMBL:ESJ98589.1,
RC   ECO:0000313|Proteomes:UP000017429};
RX   PubMed=24723722;
RA   Wannemuehler M.J., Overstreet A.M., Ward D.V., Phillips G.J.;
RT   "Draft genome sequences of the altered schaedler flora, a defined
RT   bacterial community from gnotobiotic mice.";
RL   Genome Announc. 2:e00287-14(2014).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ESJ98589.1}.
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DR   EMBL; AYGZ01000012; ESJ98589.1; -; Genomic_DNA.
DR   EnsemblBacteria; ESJ98589; ESJ98589; N508_00805.
DR   PATRIC; fig|1379858.3.peg.799; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000017429; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017429};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017429}.
FT   DOMAIN      147    279       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      359    427       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     155    162       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   454 AA;  52439 MW;  4685342772B6D0DC CRC64;
     MSNNKSESWQ HIFNEIKEKV TDKEIVKWIK DFKIVFIEAN TITLEAPNKY IKMWVEDHYL
     DYLKELLKDA YHIDANIKIV LKGNTISEKD KSNNSASEEK EDRQNHNNDY YSVPLNKQYT
     FETFVAGKSN RFAYAACMNA AKGFERLNNP IYIHGDVGLG KTHLMHAVGN QMRINFPKKN
     VICITGELYL REFLKSLSTR RMNEFNEKYE SADVLLFDDV QFIAKGNATM EEFFFLFSKL
     YSNDKQIILT SNSLPDDISD LDRRLSSRFQ SGLIVEIGTP SVDEKTAIIG NYLKINKYYI
     SDDVIKFVAE NIKSNSTRDL LGIINTIVVK GQLYNVEITV DYIQSELKSF FLQRDRVLST
     NEIIQIVCEY YNIKLIDMQS KSRAVNIVIP RNMAIYLIYK NTPSSLASIG AVFKRDHSTI
     KNSISKVDKE IAANNDYTVN TLKELSSRMK VFQR
//
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