ID V2YID1_9FIRM Unreviewed; 876 AA.
AC V2YID1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE RecName: Full=DNA mismatch repair protein MutS {ECO:0000256|HAMAP-Rule:MF_00096};
GN Name=mutS {ECO:0000256|HAMAP-Rule:MF_00096,
GN ECO:0000313|EMBL:USF27254.1};
GN ORFNames=N510_002200 {ECO:0000313|EMBL:USF27254.1}, N510_01000
GN {ECO:0000313|EMBL:ESL14966.1};
OS Firmicutes bacterium ASF500.
OC Bacteria; Bacillota.
OX NCBI_TaxID=1378168 {ECO:0000313|EMBL:ESL14966.1};
RN [1] {ECO:0000313|EMBL:ESL14966.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ASF500 {ECO:0000313|EMBL:ESL14966.1};
RX PubMed=24723722;
RA Wannemuehler M.J., Overstreet A.M., Ward D.V., Phillips G.J.;
RT "Draft genome sequences of the altered schaedler flora, a defined bacterial
RT community from gnotobiotic mice.";
RL Genome Announc. 2:e00287-e00214(2014).
RN [2] {ECO:0000313|EMBL:USF27254.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=ASF500 {ECO:0000313|EMBL:USF27254.1};
RA Proctor A., Parvinroo S., Richie T., Jia X., Lee S.T.M., Karp P.D.,
RA Paley S., Kostic A.D., Pierre J.F., Wannemuehler M.J., Phillips G.J.;
RT "Resources to Facilitate Use of the Altered Schaedler Flora (ASF) Mouse
RT Model to Study Microbiome Function.";
RL Submitted (MAY-2022) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is possible that it carries out the mismatch recognition step. This
CC protein has a weak ATPase activity. {ECO:0000256|HAMAP-Rule:MF_00096}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|HAMAP-Rule:MF_00096,
CC ECO:0000256|RuleBase:RU003756}.
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DR EMBL; AYJP01000005; ESL14966.1; -; Genomic_DNA.
DR EMBL; CP097573; USF27254.1; -; Genomic_DNA.
DR AlphaFoldDB; V2YID1; -.
DR STRING; 1378168.N510_01000; -.
DR PATRIC; fig|1378168.3.peg.1042; -.
DR eggNOG; COG0249; Bacteria.
DR HOGENOM; CLU_002472_1_3_9; -.
DR OrthoDB; 9802448at2; -.
DR Proteomes; UP000017395; Chromosome.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0003684; F:damaged DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd03284; ABC_MutS1; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR HAMAP; MF_00096; MutS; 1.
DR InterPro; IPR005748; DNA_mismatch_repair_MutS.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR017261; DNA_mismatch_repair_MutS/MSH.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01070; mutS1; 1.
DR PANTHER; PTHR11361:SF34; DNA MISMATCH REPAIR PROTEIN MSH1, MITOCHONDRIAL; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF037677; DNA_mis_repair_Msh6; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF55271; DNA repair protein MutS, domain I; 1.
DR SUPFAM; SSF53150; DNA repair protein MutS, domain II; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_00096};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|HAMAP-
KW Rule:MF_00096}; Reference proteome {ECO:0000313|Proteomes:UP000017395}.
FT DOMAIN 702..718
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
FT BINDING 628..635
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_00096"
SQ SEQUENCE 876 AA; 95705 MW; F12BA92FD3602852 CRC64;
MPEITPMMQQ YLDIKAQNPD SILFFRLGDF YEMFNEDARL VSKELDLTLT TRDRNKPPEE
RTPMCGVPYH SCDSYIARLI AKGYKIAICE QTEDPAQAKG LVDRDIIRVV TPGTVIASSM
LEDGKNNYIC AVYADSAACA LCLCDISTGE AYGASFPAGE EGLGHLRNEL ARFHPAEAVL
SSGAWSTEGL VPFLKERLSC LCENGGEARF RIKTARPLAE KQFKTGLTDI PAGDEAAVQA
AGGLLAYLYE TQKTDLSHIS HFSYYTVGQF MELDLTARQT LELTATMRGK EKRGSLLWVL
DKTKTAMGGR LLRGWMERPL LSPARIARRQ QGVADLVEDA ITREELSLAL REITDLERLA
GRVVYGSAGS RDLAALSAGL GRLPRIRALL EHCPSPLLQS LRAELDDLPQ LRDLLDRAIR
DDSEKALPFS VREGDFIRSG YHPKVDELRD LLTNASGHIV AMEVRTKEQT GIKNMKISSN
KVFGYYIEVA KSQTGLVPAD WVRKQTTVNA ERYISQELKE LEHAILSARE QITALEYQLF
CELKEAVCAQ TAQIQSAAAA VAQVDVLNSL ASVAAANGYC MPQVDGSDAL TIVEGRHPVV
EKMLKNTPFV PNDTHMDGGE DLAAIITGPN MAGKSTYMRQ VALIVLMAQM GSFVPAKSAR
VGVVDRVFTR IGASDDLASG QSTFMVEMTE VAALLQNATR QSLLILDEIG RGTSTYDGMA
IARAVLEHCA DRKRLGAKTL FATHYHELTA LEGEIAGVKN YNIAAKKRRS DVIFLRKIVR
GGADQSYGVE VAKLAGVPER VVRRAREILE ELESGNGPVT GGRPQAAPTE DAAQVSLGDI
GGEAVLKKLR MTDVNILSPI EALNLLAELK QDLNGG
//
