ID V3PWG7_9ENTR Unreviewed; 1043 AA.
AC V3PWG7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Nuclease SbcCD subunit C {ECO:0000256|RuleBase:RU363070};
GN Name=sbcC {ECO:0000256|RuleBase:RU363070};
GN ORFNames=L370_02292 {ECO:0000313|EMBL:ESN16220.1};
OS Enterobacter sp. MGH 24.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC Enterobacteriaceae; Enterobacter; Enterobacter cloacae complex.
OX NCBI_TaxID=1329828 {ECO:0000313|EMBL:ESN16220.1, ECO:0000313|Proteomes:UP000017624};
RN [1] {ECO:0000313|EMBL:ESN16220.1, ECO:0000313|Proteomes:UP000017624}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MGH 24 {ECO:0000313|EMBL:ESN16220.1,
RC ECO:0000313|Proteomes:UP000017624};
RG The Broad Institute Genomics Platform;
RG The Broad Institute Genome Sequencing Center for Infectious Disease;
RA Murphy C., Cosimi L., Cerqueira G., Feldgarden M., Hung D., Onderdonk A.B.,
RA Ferraro M.J., Hooper D., Dekker J., O'Brien T., Huang S., Quan V.,
RA Ernst C., Delaney M., DuBois A., Young S.K., Zeng Q., Gargeya S.,
RA Fitzgerald M., Abouelleil A., Alvarado L., Berlin A.M., Chapman S.B.,
RA Gainer-Dewar J., Goldberg J., Gnerre S., Griggs A., Gujja S., Hansen M.,
RA Howarth C., Imamovic A., Ireland A., Larimer J., McCowan C., Murphy C.,
RA Pearson M., Poon T.W., Priest M., Roberts A., Saif S., Shea T., Sykes S.,
RA Wortman J., Nusbaum C., Birren B.;
RT "The Genome Sequence of Enterobacter cloacae complex MGH 24.";
RL Submitted (SEP-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: SbcCD cleaves DNA hairpin structures. These structures can
CC inhibit DNA replication and are intermediates in certain DNA
CC recombination reactions. The complex acts as a 3'->5' double strand
CC exonuclease that can open hairpins. It also has a 5' single-strand
CC endonuclease activity. {ECO:0000256|RuleBase:RU363070}.
CC -!- SUBUNIT: Heterodimer of SbcC and SbcD. {ECO:0000256|RuleBase:RU363070}.
CC -!- SIMILARITY: Belongs to the SMC family. SbcC subfamily.
CC {ECO:0000256|RuleBase:RU363070}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESN16220.1}.
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DR EMBL; AYJG01000003; ESN16220.1; -; Genomic_DNA.
DR RefSeq; WP_023334678.1; NZ_KI535657.1.
DR AlphaFoldDB; V3PWG7; -.
DR PATRIC; fig|1329828.3.peg.2235; -.
DR HOGENOM; CLU_004785_1_0_6; -.
DR Proteomes; UP000017624; Unassembled WGS sequence.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0004519; F:endonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0006302; P:double-strand break repair; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR038729; Rad50/SbcC_AAA.
DR InterPro; IPR004592; SbcC_gammaproteobac_type.
DR NCBIfam; TIGR00618; sbcc; 1.
DR PANTHER; PTHR32114; ABC TRANSPORTER ABCH.3; 1.
DR PANTHER; PTHR32114:SF2; ABC TRANSPORTER ABCH.3; 1.
DR Pfam; PF13476; AAA_23; 1.
DR Pfam; PF13558; SbcC_Walker_B; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|RuleBase:RU363070};
KW DNA recombination {ECO:0000256|RuleBase:RU363070};
KW DNA replication {ECO:0000256|RuleBase:RU363070};
KW Endonuclease {ECO:0000256|RuleBase:RU363070};
KW Exonuclease {ECO:0000256|RuleBase:RU363070, ECO:0000313|EMBL:ESN16220.1};
KW Hydrolase {ECO:0000256|RuleBase:RU363070};
KW Nuclease {ECO:0000256|RuleBase:RU363070}.
FT DOMAIN 5..228
FT /note="Rad50/SbcC-type AAA"
FT /evidence="ECO:0000259|Pfam:PF13476"
FT COILED 525..580
FT /evidence="ECO:0000256|RuleBase:RU363070"
FT COILED 618..645
FT /evidence="ECO:0000256|RuleBase:RU363070"
SQ SEQUENCE 1043 AA; 118147 MW; 4C3F8813146E9F24 CRC64;
MKILSLRLKN LNSLKGEWKI DFTAEPFASN GLFAITGATG AGKTTLLDAI CLALYHETPR
LQKVSQAQND LMTRDTAECL AEVEFEVKGT AYRAFWSQNR ARNQPDGNLQ APRVELARCE
DGKILADKVT DKLEQTAALT GLDYGRFTRS MLLSQGQFAA FLNAKPSDRA ELLEELTGTE
IYGQISAMVF EKHKAARSVL EKCEAQAAGV VLLSEEQQQE LQQSLQALTD EEKTLLVQQQ
SQQKDFQWLT RRDELVLEQQ RVTTMQQQAQ QALTNAAPEL AKLQLALPAA QLRPLWAHQQ
EQTARLTQTQ QRIIEVNTRL QAKTALRARI RHTAQRNHEQ LQTELTALAQ WLAEHERYRL
LGQEIAGWRA QLSQLNRDKT QLASLAARMG ELRNRLAEMP ENALSLTADE VSAAMEQQSR
SRTLRQRLTS LHARYQPLQK RLRQSGENVQ KARADQNKLN DTLTLRRQQY KEKHQHYLDL
KALCEREATI KDLESYRSRL EAGKPCPLCG SSEHPAVEQY QSLELTDNQR RRDALEKEVA
ALKEEGLLVL GQVNALTQQI QRETDEAQTL SQEEQALTKE WMEACASLHI ALNIQEDITP
WMNEQEQYER QLYQLSQRLT LQNQLNEQEV QERQFQQQLT AARQALEHAL LSLSLNVPED
GNEAAWLHAR EAEFAQWQEK QTQHGVLLER INALKPLLDT LPETHSEEAE PTIPAGWRDV
HDECVSLQSQ LTAQQQQEKL EQERLQQSQT QFTAALSASC FADRDAFLAA LLDDDAIRHL
EQLKQSLESQ IQQAAVLSGQ ANQQLQAHLA LRPERLDADA PALQSQLQQL AQRLRENTTH
QGEIRQQLKQ DSDNRQHQLA LMQQIDEAAR QADDWGYLNA LIGSSTGDKF RKFAQGLTLD
NLVWLANQQL NRLHGRYLLQ RKASDALELE VVDTWQADAV RDTRTLSGGE SFLVSLALAL
ALSDLVSHKT RIDSLFLDEG FGTLDSETLD TALDALDALN ATGKTIGVIS HVEAMKERIP
VQIKVKKING LGYSRLDREF AVQ
//
