ID V3ZBP4_LOTGI Unreviewed; 572 AA.
AC V3ZBP4;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=G-protein coupled receptors family 3 profile domain-containing protein {ECO:0000259|PROSITE:PS50259};
GN ORFNames=LOTGIDRAFT_165568 {ECO:0000313|EMBL:ESO88443.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO88443.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO88443.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB202685; ESO88443.1; -; Genomic_DNA.
DR RefSeq; XP_009060851.1; XM_009062603.1.
DR AlphaFoldDB; V3ZBP4; -.
DR STRING; 225164.V3ZBP4; -.
DR EnsemblMetazoa; LotgiT165568; LotgiP165568; LotgiG165568.
DR GeneID; 20240134; -.
DR KEGG; lgi:LOTGIDRAFT_165568; -.
DR CTD; 20240134; -.
DR HOGENOM; CLU_469500_0_0_1; -.
DR OMA; TYLSWET; -.
DR OrthoDB; 5396723at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004965; F:G protein-coupled GABA receptor activity; IEA:InterPro.
DR CDD; cd15047; 7tmC_GABA-B-like; 1.
DR InterPro; IPR002455; GPCR3_GABA-B.
DR InterPro; IPR017978; GPCR_3_C.
DR PANTHER; PTHR10519; GABA-B RECEPTOR; 1.
DR PANTHER; PTHR10519:SF20; GAMMA-AMINOBUTYRIC ACID TYPE B RECEPTOR SUBUNIT 2; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 52..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 128..149
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..211
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..242
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 84..298
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
FT REGION 363..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 519..544
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 365..407
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 572 AA; 63719 MW; 4BE186F80A0F9AA5 CRC64;
METVKENGLV VAVMSWIIGC VIALVSLVYL VLNIKLRNTR LIKMSSPNLN CLVASGGILA
SITCLLYGVD HFIDKNHQQL SNFCQLRAAF LTCAFTLLYG PLVAKCWRVN RIFEQGSLKR
VVIRDSRLYL LIGALLFGDV LMMAAWQIVD PLHYTTVASL TKEPKLWKGN SSINLSVTII
PTCSCNNLPT WLTLMFLLKA PVLITSLVLA WRTRDVLIPS MNDSYSIIIS SLTTLFVTAT
VFTLKTIHFA SPDIVTVVIL LGIGISTIVT TSMVFVPKLL LWWRNPEKSA LRLSINSKST
HNVTGINTAD ILEDDMFTMV AENISMKKSL QEKDAAINVL QGHLTNAQQK LMEISLDQEA
RLDSGLDSDG NTTSLEDSPK RGTPSTPPQN TTVSLPETPR QPSLKSFSSS SSVVEYHKLC
RLRDSIAEDL TLARDLSSDI RISITKDIHA AEKITRKGSF RYESVKSRQE LAGSITKSYN
LTNSCDTYDY VSSCVTSSSN LHHPPLKALQ YSSSESIDTL PNDKLYPDNH RRKKQKRIPR
RNELNKSVYF IPTDPQQVNC AMTKSMDTDT FV
//
