ID V3ZDA1_LOTGI Unreviewed; 4084 AA.
AC V3ZDA1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE RecName: Full=AAA+ ATPase domain-containing protein {ECO:0000259|SMART:SM00382};
GN ORFNames=LOTGIDRAFT_210054 {ECO:0000313|EMBL:ESO89088.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO89088.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO89088.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KB202619; ESO89088.1; -; Genomic_DNA.
DR RefSeq; XP_009060130.1; XM_009061882.1.
DR STRING; 225164.V3ZDA1; -.
DR EnsemblMetazoa; LotgiT210054; LotgiP210054; LotgiG210054.
DR GeneID; 20246188; -.
DR KEGG; lgi:LOTGIDRAFT_210054; -.
DR CTD; 20246188; -.
DR HOGENOM; CLU_000038_0_0_1; -.
DR OMA; FFQSCAK; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF1; DYNEIN HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 1381..1520
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2035..2182
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 98..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 743..812
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2875..2937
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 108..122
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 4084 AA; 466932 MW; DEB42A18FA84CC3B CRC64;
MTTPLQSSSK SRGLPGLPAL PSTVKEPSDL YQIVLRNSQH PPLMKGTSWT LAAPFKEEKY
HRTPSESIAN NYTPSASTLK LRDLPKIYRN KAKSKLFLLS PRGPTVSPSK KRRKDGSPER
KSEQKSSNGS SPLPDIEELP PSRPLTPTEQ IDIMLQAETE LLEKTGSASD RDLERYYYYI
EKGINKEMLA PPQPGQLKEI ENLVPQALLE NPELEDIHTE LIEEIHEDHR QSIRKSIVDY
ILKDPEEKER LFIAWTPKPF PQRLIRAPVP WHDMYQRMKS YNGTYLFITN PIMLALQNVW
FDKFAHQRFV NLKELLNADL PLLPSEFESL VKKQCWEAHE VLRKEWVPTC AKLFIDMKDT
WEYLVPQNEV DSTELVAEFF SCVAALMSIQ LRSMVINSLA DFLAFFQIHE AGNDFGEEFD
ELKFVMKQVM IIKLRVQDPK ILFDPLFRDI RDIILRCFTE IIASAEGLSR VSLLRKIPIP
IDTMFRNIYL SWSYLHYFAK ISHPLNFNDK LLLLVECELF PDMRNQKLHL RSVKLEETLV
TDFIDKAMEI FKDNTVGPQK YLNTYKKYSD LLNNKAEQDV SSFLKERHSI QAFKQKINSL
QDLKNEIALL RITVPLSMFC LDCVQLNQEL CLRAQNLREK LITFEVDENR DLNRGICRRY
DEMTDKVSEM PDTTQEIVET QEFLKASMEV TVYKLKDEID EAANRLMFLL DYAIFPLFHW
PEHIRTVFEL NQSRILNKRD HIEDELRKKV SVFENRLAEY MSKVESYKKK EIMSSDEMKN
NCENLKHLHE CLEAARDELQ AINEEERLLE WEQSSFPDLQ LMFTMKEPYE KLWTTAYSFH
QKHELWMNGA FQELNAEDIE NEVGDMWRTM YKLTKTFGDQ AGPRRIADSV KGKIDKFKQH
MPILQTICNP GIRDRHWDMM SDIVGFNIKP EGDISLSKML EYGLNKHLAR LEEIGAAAAK
EYSLEKALEK MKFEWKDLVF DMIPYRDTGV SILSSVDEIQ LLLDDHIVKA QTMRGSPFIK
PFEAEMKEWE EKLVLMQDII DEWLKCQATW LYLEPIFSSE DIMAQMPEEG RKFGIVDSYW
RDIMTESIKD THCLAATAQA NMVGRLREAN VLLEEIQKGL NAYLEKKRLY FPRFFFLSND
ELLEILSETK DPTRVQPHLK KCFEGIHKLE FTEQQEIVGM ISSENETVPF STKIYPAKAK
GMVEKWLLQV EDVMMSSIRK VILESVKAYK ETPRKRWVIE WPGQVTLAVS TIYWTSEVTE
AMKEPNGMNE YLQKSNKQIE EIVELVRGKL EGGARTSLGA LTVVDVHARD VVAILAKNKI
RSANDFDWLA QLRYYWEDDV IVRMITTDIN YGYEYLGNTP RLVITPLTDR CYRTLMGALK
LNLGGAPEGP AGTGKTETCK DLAKAVAKQC VVFNCSDGLD FKAMGKFFKG LAQAGAWACF
DEFNRIELEV LSVVAQQIHT IQQAIAGKMK RFIFEGTELS LNPTCTMFIT MNPGYAGRQE
LPDNLKVLFR TVAMMVPDYG LIGEIVLYSM GFVDARSLSN KIVATYKLCS ELLSSQHHYD
YGMRAVKSVL TAAGNLKLKY PEQDEAVLLL KAISDVNLPK FLSQDVPLFE GIISDLFPGI
ELPSPDYGVF MESLRENIVK RKLQTVPWFE DKIIQIYEMI LVRHGLMIVG EPLGGKTQAY
QALADTLGDL CAAGLFNEFR VQYRILNPKA ITMGQLYGCF DPVSHEWSDG VLANTFREYA
SNPNEDRKWI LFDGPVDAVW IENMNTVLDD NKKLCLMSGE IIQMSNTMNL IFEPADLEQA
SPATVSRCGM IYMEPHQMGW KPLKDSYMQH ELPKNLSEEH VELVTDLFEW LIDPCLEFIR
TKCKTLINTS NMHLVQSHMR LYTCLMDEII AAINQKTEEG EEGGEGHSEA LSSQQIFLWL
QGLFIFSLIW TIGATITGES RKQFDVFFRN LIGGTNADHP KPKSIKLTKS NSIPEKGSIY
DYCFEKKSSG TWTDWMDTVP KGSMGIAANA KVSDLIITTM ETLRQTYFLQ TYLSHEVPIL
FVGPTGTGKS AITNNHLLKL PKDLYVPNCI NFSARTSANQ TQDIVMSKLD RRRKGVYGPP
MGKKSVVFVD DLNMPAKEKY GAQPPIELLR QWIDHGHWYD RKDTSKVFLT DVIFVSAMGP
PGGGRNDITG RFTRHLNILS IDEFDDATMT RIFTTITDWH FARGFDPAFT KNGKLLVQAT
MAVYKEAVEK FLPTPSKSHY VFNLRDFSRV IRGVLLVPST NLTEMEKLVR LWIHEVYRVF
YDRLIDDEDR LTFFNMVKEM CQTHFKLSID KVLGHLSKSG NVVDDNIRSL FFGDYMNAET
KIYDEVIDLK ELTSMIEHYL EEYNTMSKAP MRLVMFKFAI EHVSRVSRVL KQDNGHALLV
GIGGSGRQSA AKLASFMADY DLFQIEITKN YSVSDWREDL KKLLIKAGTE GKPTVFLFSD
NQIKDESFME DISMILNTGD VPNIFAADEK AEIIEKMQNV ARNEAKKIDA TPLAMYNFFI
ERVKQNLHIV LAMSPIGDAF RNRLRMFPSL INCCTIDWFQ AWPEDALEMV ANKFLEDVEL
EDNVRIETVV MVRYFHESVR RLSERYMDML RRHNYVTPTS YLELIMTFKN LLGKKQNEIT
TMKNRYITGL EKLEFAASQV SIMQQELTDL QPELIKTSAD TEKLMIKIEQ DTVEVEAKKE
VVAADEAVAN EAAAEAQAIK DECEGDLAEA IPALEAAISA LNTLKPADIT MVKSMKNPPA
AVKLVMESIC VMLAIKSERK PDPGGSGKMI EDFWGPSQKL LGDLKFLDRL KSYDKDNIPP
PIIKKIREKY SSNPEFEPNL IKNASTACEG LCRWVRAMDI YDKVAKVVAP KKAKLAGAES
ELAVQMEKLN EKRGQLQAVT DKLQALNDEF EAMTQKKKEL EDNIDLCSKK LDRAEKLIGG
LGGEKDRWTE AAKVLGIKYV NTTGDVLLSA GVVAYLGAFT VDFRQDILKE WHQLCIEREI
PCSSVFSLNA TLGEPVKIRA WNIAGLPVDS FSVDNGIIVS NSRRWPLMID PQGQANKWVK
NMEKENKLGI IKLSDANYMR TMENAIQFGT PVLLENVAEE LDPILEPILQ KQTFKQQGVE
YIRLGDSVIE YSEDFKLYIT TRLRNPHYLP EISVKVALLN FMITPLGLED QLLGIVAAKE
KPELEEKKNQ LIIESAANKK QLKEIEDKIL EVLSSSQGNI LEDETAIKVL SSSKTLSEEI
SAKQEIAAAT EIEIDETRNG YKPVAVHSSI LFFCISDLAN IEPMYQYSLT WFINLYLQSI
INSVPSDNLE ERIFNLNDHF TNSIYRNVCR SLFEKDKLLF SFVLCYGIMK GQGKIDEEVW
RFLLTGGIAL DNPYPNPCPE WLTEKSWSEI VRASDLKKLK GYKEHFQENT AKWRQLYDSS
SPHDYKLPSP FDAITGMGKM VILRTLRPDK IVPAVQTFIV DNLGQSFIEP PTFDLPGSFA
DSNCCAPLIF ILSPGADPMA ALLKFGQDMG YSGQRIQTIS LGQGQGPIAA KMIENAIKDG
SWVVLQNCHL ATSWMPKLEK ICEEVITPEN TNKDFRLWLT SYPSDEFPVS ILQNGVKMTN
EPPKGLRANL LRSYLNDPIS DPAFFDGCNK PERWHKMLFG LCFFHAMVQE RRKFGPLGWN
IPYEFNESDL RISMRQILMF LNDYEELPLP AVTYLTGECN YGGRVTDDKD RRLLMSLLSI
FYTEEIITTE GYKFSPTGIY YAPPEGPYNN YIEYIRTLPL IQNPEVFGLH ENADVTKDNQ
ETQTLFDSIL LTLPRQSGGG GKSSGEVIQD LAADILSKLP SDFDIPYVIK KYPVMYSESI
NTVLRQELIR FNRLTSVVRS SLQNLCKAIK GLVVMSSELE EIFNSMLVGK LPAVWAAKSY
PSLKPLGSYV TDLLQRLKFF DDWIKNGMPV TFWLSGFYFT QSFLTGVSQN FARKTKIPVD
LVGFEFEVTK EEKEMTVKPE NGAFVYGLFL EGARWDREKM VIGESKPKIL FDTIPVILLK
PNKTDQFTNI PSYDCPVYKT SARRGTLSTT GHSTNFVMYI KLPSDKPQSH WINRGVAALC
QLDD
//
