GenomeNet

Database: UniProt
Entry: V3ZIY7_LOTGI
LinkDB: V3ZIY7_LOTGI
Original site: V3ZIY7_LOTGI 
ID   V3ZIY7_LOTGI            Unreviewed;       842 AA.
AC   V3ZIY7;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   07-JUN-2017, entry version 18.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=LOTGIDRAFT_108161 {ECO:0000313|EMBL:ESO84217.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO84217.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO84217.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KB203566; ESO84217.1; -; Genomic_DNA.
DR   RefSeq; XP_009065338.1; XM_009067090.1.
DR   EnsemblMetazoa; LotgiT108161; LotgiP108161; LotgiG108161.
DR   GeneID; 20230311; -.
DR   KEGG; lgi:LOTGIDRAFT_108161; -.
DR   CTD; 20230311; -.
DR   KO; K02154; -.
DR   OMA; SHNSLIA; -.
DR   OrthoDB; EOG091G01BI; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030746};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    401    425       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    446    464       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    536    557       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    569    589       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    638    657       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    771    795       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       94    135       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   842 AA;  96744 MW;  C6C8D408A34E3111 CRC64;
     MGSLFRSEEM TLCQLFLQTE ASYACVSELG ELGIFQFKDL NQNVNAFQKK FVNEVRRCEE
     MERKLRYIEK EIKKDELKIP DFGENPKAPA PKEMVDLEAQ FEKNESELRE VNTNAEALKR
     NFLELTELRE VLKKTQTFFS VVNLPNIVGE AQHALVIEES GPAQAVQLGF IAGVIPREKV
     PPFERMLWFA CRGNVFLRYE EIQQPLEDPH TGEAKHKAVF MIFFQGEQLK ARVKKICEGF
     RAALYPCPES TQERQEMLRG VTTRLEDLKM VLNQTEDHRR RVLVGAQKEI RNWIIKVEKI
     KAIYHTLNMF SFDISHNSLI AEGWCPVQSL EEVRRVLKEG EKLSGSTIPS ILHPLKTKEV
     PPTFFKTSRF TQGFQNIVDA YGVATYQEVN PMPYTIITFP FLFSVMFGDA GHGTLMFLFG
     LWMVIKEKSL LSQKSNNEIW NTFFGGRYII MLMGLFSIYT GMIYNDAFSK SFNIFGSAWH
     STYTDGDLQG DGETATLVLD PGPFYRNGTP YPFGIDPIWQ SAKNKITFLN SFKMKMAVIL
     GISQMVFGVC LSIFNHLHFK MIVCLFCEFL PELIFLLALF GYLIFMVYYK WLVFDVTESG
     CAPALLIQYI NMFMFKYEDA SEKTDCDVQA TFYENQQTIQ TIFVIMAVLS VPVLLLVKPF
     YLRSLHNAKT HPPKVEKDTS KSVNGKSKPV GEDVKVSYGH ALINHGEDEE EFEFSEIFIE
     QAIHTIEFCL GCISHTASYL RLWALSLAHA QLSEVLWTMV LHIGLSMDMQ YLGGLIIFVV
     WMFWANLTIA VLLVMEGLSA FLHTLRLHWV EFQSKFYSGN GYLFQPFGFK HILDIDSLQE
     IK
//
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