ID V3ZNY5_LOTGI Unreviewed; 356 AA.
AC V3ZNY5;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 03-MAY-2023, entry version 41.
DE RecName: Full=Protrudin {ECO:0000256|ARBA:ARBA00015523};
DE AltName: Full=Zinc finger FYVE domain-containing protein 27 {ECO:0000256|ARBA:ARBA00032025};
GN ORFNames=LOTGIDRAFT_162115 {ECO:0000313|EMBL:ESO93093.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO93093.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO93093.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Cell projection, growth cone membrane
CC {ECO:0000256|ARBA:ARBA00004460}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004460}. Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004477}. Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004195}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004195}.
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DR EMBL; KB201977; ESO93093.1; -; Genomic_DNA.
DR RefSeq; XP_009056297.1; XM_009058049.1.
DR AlphaFoldDB; V3ZNY5; -.
DR STRING; 225164.V3ZNY5; -.
DR EnsemblMetazoa; LotgiT162115; LotgiP162115; LotgiG162115.
DR GeneID; 20238919; -.
DR KEGG; lgi:LOTGIDRAFT_162115; -.
DR CTD; 20238919; -.
DR HOGENOM; CLU_060341_0_0_1; -.
DR OMA; FLLRWKM; -.
DR OrthoDB; 38671at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0032584; C:growth cone membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0071787; P:endoplasmic reticulum tubular network formation; IEA:InterPro.
DR GO; GO:0072659; P:protein localization to plasma membrane; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd15723; FYVE_protrudin; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR042405; Protrudin.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR14543; PROTRUDIN; 1.
DR PANTHER; PTHR14543:SF1; PROTRUDIN; 1.
DR Pfam; PF01363; FYVE; 1.
DR SMART; SM00064; FYVE; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT TRANSMEM 52..69
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 75..92
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 159..190
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 269..336
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
SQ SEQUENCE 356 AA; 41074 MW; 229E79E17ACF2BE3 CRC64;
MKTMEEEEKK ETEARVDLAD FVFEVDRFTK LIEPFAFCFY FLDDVRRWRN PVLSGVLLVT
LNLSCLILTK GSVFVFASLA VICIASVSLF HIHTKILNKV LPETRRLPRV YNGEDINTLQ
TVRQFRYSLI EMHDFVIKCN EYLSSWYCIL KWEKTLTSLI FHIEVCVFIL SLVVMSTRIN
CFMFFNWFFL CHQDSINYIK NMVVPDENKV KLRESNGVTP DIKSKTDTVD VSDEDNMVPL
EDNMVPLDST PNKPGMVARL LELKRRRQQA SSENCFACKV AFSAFLKRRY YCRHCGKDFC
NKCCNQKVPR SVFGATAPAA QTETVLVCNN CQKLLATGKD IKSKVWAENF GKQSGI
//
