ID V3ZUH2_LOTGI Unreviewed; 3942 AA.
AC V3ZUH2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 51.
DE RecName: Full=EF-hand domain-containing protein {ECO:0000259|PROSITE:PS50222};
GN ORFNames=LOTGIDRAFT_219632 {ECO:0000313|EMBL:ESO88007.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO88007.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO88007.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR EMBL; KB202793; ESO88007.1; -; Genomic_DNA.
DR RefSeq; XP_009061321.1; XM_009063073.1.
DR STRING; 225164.V3ZUH2; -.
DR EnsemblMetazoa; LotgiT219632; LotgiP219632; LotgiG219632.
DR GeneID; 20246882; -.
DR KEGG; lgi:LOTGIDRAFT_219632; -.
DR CTD; 20246882; -.
DR HOGENOM; CLU_000038_0_0_1; -.
DR OMA; GRDIPCS; -.
DR OrthoDB; 166463at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005929; C:cilium; IEA:UniProtKB-KW.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR46961; DYNEIN HEAVY CHAIN 1, AXONEMAL-LIKE PROTEIN; 1.
DR PANTHER; PTHR46961:SF9; DYNEIN HEAVY CHAIN, CYTOPLASMIC-LIKE PROTEIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
DR PROSITE; PS00018; EF_HAND_1; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 2158..2193
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT COILED 600..660
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2732..2797
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 3942 AA; 451870 MW; 54F908C8D3F8AA95 CRC64;
MFFICTGESR RKKAKKLKPI DAKTGNIEQF KQPKKDREQF RKALVDIIIL PKSSTASISG
ELPPLSRTGS PTTAEKDILR YYYYIHNGID TEHVAPMEDS WLENVLDLVP FNLRGGHEET
IESLSDEMRE DYLLSVKKAI VDFVLKDPRE KDEDKKEKLP PHREELAIVP KPWNRSYCIS
NDLISQNLFV TNPCMMQVLD LWHVSFSGLR FIDIEEFHTR EESMELQTFQ NLCMRHIDAA
KERLMKKWFP EVQTIFYQGN KRKQVPSNQD LDKLESFFNC AATLMTENLQ QLTLNSLNDF
TDLLVQPSTS TRAFEHSGFI LRMILDDTTI KFEPQFKDFE VVLLNVYDVI LKASCVIPRV
ETKLYSEWNG SKSKPVLKPV VLDAILERHK QKVRDLIKRE SQLPVEHCKV YEKYNFLISK
QADIDVEQFM TKEEHSFDDY AKEVDKYHKL IEDVSYNSQK IVRVGMFEIH SEELIRALAK
RADALKSKLL MRMCKDHQEA NKALCNDYEA IAEKALTTPA NTEALMELKA YIEKVESDTI
FVMEKRLSES KDRLTFLSDF AQFSPAEMRL NSQVFTWHGR MPAVFEEHKL ICSEKRGQYE
EALQLKRERF TEELESYQKQ VEEFQQFGDM TEIQRYLRKA QALDTKLQAA ADKIEAFNTE
EEAFGWETTA YPQRQTVINT LKPYLTLYET TVDFNTKYKY WMDGPMSGVN PDDVDAEVGN
IWRGLYKLEK TFENVPAAKK IVGKVKTKVD EFKGHMPLVQ TLFNPGLRDR HWEQISEMAG
YTIKPDENSC LSKFVDMNLE PYIPKFEGIS EAASKEYSLE KAMESMKNEW APFEFTIIPY
RESGTSILSS VDDIQQVLDD HIVKTQTMRG SPFIKPFEAE IKEWETKLML LQDILDEWLK
VQATWLYLEP IFSSPDIMAQ MPEEGRRFST VDKNWRDIMK SAVVDKHVLA VLKIDKILEK
FKKSNELLEL IQKGLNEYLE KKRLYFPRFF FLSNDELLEI LSETKDPMRV QPHLKKCFEG
IAKLEFTDVL DITHMKSSEG EIVQLKDVIS TSKARGQVEK WLLELEVDMI GSLHKVIGES
MEAYKNTNRI EWVKVWPGQA VLCVSQAYWT TFVNDALETG PEAMQTYLEL NNSQINDIVD
LVRGKLSKQN RVTLQALIVL DVHARDVLTL LVKDGVQNNL DFNWLSQLRY YWEDGNMITR
MINSMLKYGY EYLGNSGRLV ITPLTDRCYR TLFGALHLHL GGAPEGPAGT GKTETTKDLA
KAVAKQCVVF NCSDGLDYIA LGKFFKGLAS CGAWSCFDEF NRIDLEVLSV VAQQILTIQR
GISSGADSLL FEGTEIKLDP TCSVFITMNP GYAGRSDLPD NLKALFRTVA MMVPDYAMIA
EISLYSCGFV VARPLSVKIV AVYRLCSEQL SSQHHYDYGM RAVKSVLTAA GNLKLKYPEE
DENILMLRSI IDVNLPKFLN HDLPLFHGIT SDLFPGIKLP TPDYEILNEA IKENCIKMNL
QCTNFFLEKI QQIYEMMIVR HGYMIVGEPF GGKTAAYRVL AGALNDIHEK GLMDENKVQI
TIINPKAITM GQLYGQFDPV SHEWSDGILA VSYRAFASST TPDRKWLIFD GPVDAVWIEN
MNTVLDDNKK LCLMSGEIIQ LANTTNLMFE PMDLEVASPA TVSRCGMIYM EPSSLGWRPL
VKSWLHTLPS TFTDNYKTVI NDLFERFIDP LLRVVRKGGV KELSPTNDSN LVKSLMNLMD
CLFDEFQDEA KIAQLEEREI TTWLESIFFF ATTWSIGASS DDMGRVKFDK IFRELISVSM
TEETRKMLVL SDLVEPPMKP YLNPFPPKGK VYDYRFIKEG AGKWVLFSEE IKDSPPIPKD
AAFNEIIVPT IDTVRYTYLM SLLILHEKPS LFVGPTGTGK SCYIIEFLLN KLDKTLYKPN
IINFSAQTSA NQTQNIIMSK LDKRRKGVFG PPLGKKAVVF VDDLNMPIRE VYGAQPPIEL
IRQWLDHWNW YDLKDTTPIK LIDIQFMGAM GPPGGGRNQV TPRFLRHMNT VTINEFDDDT
MNTIFRRIMD WHITSRGFSN EFKPCIDQIV HATLQVYKEA MENLLPTPAK SHYLFNLRDF
SRVIQGVLLS TPDTMEEPSS MKRLWIHEVV YRVFYDRLVD STDHTWFYNH LREVSKSKLK
EDFDQLLIHL DRDNDGKLTE DDLRSLIFCD FSDPKSDKKD YLEVHDLEQL RRVVEVYLEE
FNNMSKKPMN LVLFRFAIEH VSRIARILKQ PRSHALLVGV GGSGRQSLTR LAAHMADYDL
FQVEITKSYT QYEWREDLKR ILRKSTETDN HAVFLFSDTQ IKQESFLEDI NNLLNAGEVP
NLYPLDEKQE ICEKMRQIDR QRDKTKQTDG SPVSLFNFFI SRVRDQLHVV LAMSPIGDSF
RNRLRKFPSL VNCCTIDWFQ SWPEDALQAV AMRFLEEIEM PDAEKNGCIS MCIRFHTSTR
DLSDRFLLEL ERHNYVTPTS YLELINTFKT LLDKKRGEVM KQKQRYEVGL EKLDSAASQV
AVMQKELTDL QPQLVEASKE VAEIMITVEK ESVEVAKVEK VVKADEAVAN EQAKAAQAIK
DDCDSELSEA IPALNAAIAA LNTLTPQDIT LVKSMKSPPA GVRLVMEAIC VLKGVKAEKV
PDPSGSGKKI EDFWGPSKKL LGDMKFLESL YNFDKDNIPV SIMKIIRSKY MTNPDFDPEK
VKVASTACEG LCKWARAMDV YDRVAKVVAP KKEALKKAQG ELNVAMASLE KKRASLREVQ
EKLFKLEEQL AKNKQKKVDL ENEVDLCSKK LERAEQLIGG LGGERDRWSV AARELGKKYI
NLTGDVLVSS GIVAYLGAFT SAFRMDQSTQ WISEIKSNGI PCSDDFSLVN TLGEPVKIRA
WNIAGLPTDN FSVENGIIIS NGRRWPLMID PQGQANKWVK NMEKANNLHV IKLSDADFVR
TLENCIQFGT PVLLENIQEE LDPLLEPLLL KQTFKQGGSI CIKLGDSTIE YSQDFKFYIT
TKLRNPHYLP ETSVKVTLLN FMITPEGLED QLLGIVVAKE RPELEEEKNA LIIQSADNKR
QLQEIEDKIL EVLSSSEGNI LEDETAIKVL SSSKKLANEI SEKQAIADET EKKIDTARLG
YKPIAIHSTI LFFSIADLAN IEPMYQYSLT WFINLFVMSI ENAERSDDLE TRLGNLHNHF
TYSLYCNVCR SLFEKDKLLF SFLLCVNILK HNKEVDDDEW RFLLTGGIGL DNPHSNPTTW
LPSKSWDELC RLDDMPRFKD IRKKFVNYKD AWKVLYDSPE PHHEKHPGEW NDRLGMFQKM
LVLRCLRPDK VIPAVQEFVT EKIGKKFIEP PPFDLAGSYG DSTCIAPLLF ILSPGADPMA
ALLKFADDQG FGGAKFDSLS LGQGQGPIAL KMIEKGIKEG TWVMLQNCHL AASWMPTLEK
ICEELNPETT HPDFRLWLTS YPSTTFPVSI LQNGVKMTNE PPKGLRFNII KSYMSDPISD
PEFFNGVKLE KEFRKMLYGL CFFHALVQER RKFGPLGWNI PYEFNETDLR ISTQQLAMFL
NDYDTVQFDA LRYLTGECNY GGRVTDDWDR RTLLTILNKF YCKEITEDDQ YHFDHSGIYY
APPEGDHESY INYTHNLPLN PSPEIFGMHP NADIKKDQTE TQLLFDNILL TQAKASSEGG
KSTDDVVDEV AADILSKLPP NFDNDAALRK YPTSYKQSMN TVLVQEMVRF NRLVEVVRSS
LSNIRKAIKG LVVMSAELEE VVLSILKGKI PGMWMKRSYP SLKPLGSYVT DFLARLKFLQ
DWYDNGPPST FWLSGFFFTQ AFLTGAQQNY ARKYTIPIDL LGFDYEVLED KEYPVAPDDG
VYVYGLFLEG ARWDRKTKKL NESLPKVLFD SMPVMWIKPI KRSDLVEDNS YKCPVYKTSE
RRGTLSTTGH STNFVIGMMI PSNKPQKHWV GRGTALLCQL DN
//
