ID V3ZV83_LOTGI Unreviewed; 406 AA.
AC V3ZV83;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=VOC domain-containing protein {ECO:0000259|PROSITE:PS51819};
GN ORFNames=LOTGIDRAFT_167006 {ECO:0000313|EMBL:ESO86490.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO86490.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO86490.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- COFACTOR:
CC Name=Fe cation; Xref=ChEBI:CHEBI:24875;
CC Evidence={ECO:0000256|ARBA:ARBA00001962};
CC -!- SIMILARITY: Belongs to the 4HPPD family.
CC {ECO:0000256|ARBA:ARBA00005877}.
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DR EMBL; KB203049; ESO86490.1; -; Genomic_DNA.
DR RefSeq; XP_009062727.1; XM_009064479.1.
DR AlphaFoldDB; V3ZV83; -.
DR STRING; 225164.V3ZV83; -.
DR EnsemblMetazoa; LotgiT167006; LotgiP167006; LotgiG167006.
DR GeneID; 20240505; -.
DR KEGG; lgi:LOTGIDRAFT_167006; -.
DR CTD; 20240505; -.
DR HOGENOM; CLU_034004_2_0_1; -.
DR OMA; ILNTEHY; -.
DR OrthoDB; 2898711at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0003868; F:4-hydroxyphenylpyruvate dioxygenase activity; IEA:InterPro.
DR GO; GO:0009072; P:aromatic amino acid metabolic process; IEA:InterPro.
DR Gene3D; 3.10.180.10; 2,3-Dihydroxybiphenyl 1,2-Dioxygenase, domain 1; 2.
DR InterPro; IPR005956; 4OHPhenylPyrv_dOase.
DR InterPro; IPR029068; Glyas_Bleomycin-R_OHBP_Dase.
DR InterPro; IPR004360; Glyas_Fos-R_dOase_dom.
DR InterPro; IPR037523; VOC.
DR PANTHER; PTHR11959; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE; 1.
DR PANTHER; PTHR11959:SF10; 4-HYDROXYPHENYLPYRUVATE DIOXYGENASE-LIKE PROTEIN; 1.
DR Pfam; PF00903; Glyoxalase; 1.
DR SUPFAM; SSF54593; Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase; 1.
DR PROSITE; PS51819; VOC; 1.
PE 3: Inferred from homology;
KW Iron {ECO:0000256|ARBA:ARBA00023004};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 176..332
FT /note="VOC"
FT /evidence="ECO:0000259|PROSITE:PS51819"
SQ SEQUENCE 406 AA; 45970 MW; 72070CC6C258D22E CRC64;
MRVENGIKVV EDFVLKYGFT IVGERIHPLF HQWMLEVGMC RFLITEVSNE VSRESTRLAD
DVFISPLDGS SVDCRTTCFK RSFDIVNDVA LEVKDVETHV RKLSKNNVVV LKPLRKIADK
NGEILIVTVK SCLDNIIHTL IQIIHLKGKL LPGFSSPSSC SEALNRRRQR GTNMSHVDHV
TFVCESGKSP WVISWYEKCF GMKKFSLNRH SDDGSLVVNG NNSGLRLSAF DYWKCSETGL
FHPEDNKFTF VLAEPIGRGQ SHVKTFLSKH EGAGVQHVGL HTSNMVTTLQ ILKNNGVQFV
EPPFTYYEEE YFLKKVDELG DCLEENVEDI ISQGILLDSE NTLNITTGEQ QTEERYLMQK
FTKPIFKEET FFLEIIQRHG ATGFGFGNVM ALCRAVEKLK CTKASG
//
