ID V4A7L7_LOTGI Unreviewed; 374 AA.
AC V4A7L7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 40.
DE RecName: Full=Thyrotropin-releasing hormone receptor {ECO:0000256|ARBA:ARBA00018873};
DE AltName: Full=Thyroliberin receptor {ECO:0000256|ARBA:ARBA00032251};
GN ORFNames=LOTGIDRAFT_122499 {ECO:0000313|EMBL:ESO91015.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO91015.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO91015.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- FUNCTION: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand
CC binding, this G-protein-coupled receptor triggers activation of the
CC phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
CC {ECO:0000256|ARBA:ARBA00004100}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000256|RuleBase:RU000688}.
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DR EMBL; KB202284; ESO91015.1; -; Genomic_DNA.
DR RefSeq; XP_009058286.1; XM_009060038.1.
DR AlphaFoldDB; V4A7L7; -.
DR STRING; 225164.V4A7L7; -.
DR EnsemblMetazoa; LotgiT122499; LotgiP122499; LotgiG122499.
DR GeneID; 20232113; -.
DR KEGG; lgi:LOTGIDRAFT_122499; -.
DR CTD; 20232113; -.
DR HOGENOM; CLU_009579_6_5_1; -.
DR OMA; TIITCGY; -.
DR OrthoDB; 3471593at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004997; F:thyrotropin-releasing hormone receptor activity; IEA:InterPro.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR002120; TRH_rcpt_1.
DR PANTHER; PTHR46061:SF3; THYROLIBERIN RECEPTOR; 1.
DR PANTHER; PTHR46061; THYROTROPIN-RELEASING HORMONE RECEPTOR; 1.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00751; THYROLIBRINR.
DR PRINTS; PR01846; TRHRFAMILY.
DR SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|RuleBase:RU000688};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transducer {ECO:0000256|RuleBase:RU000688};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU000688};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 47..73
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 85..106
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 126..150
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 170..188
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 223..245
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 285..306
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 326..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 65..347
FT /note="G-protein coupled receptors family 1 profile"
FT /evidence="ECO:0000259|PROSITE:PS50262"
SQ SEQUENCE 374 AA; 42988 MW; 3A99B7558EC4115A CRC64;
MNQSEFINDT LQVLFSHHGA APPLSENETF IMENHTLLRP THYSTSFQLI AATISAIIFI
VGLIGNVLVV IVIARTRSMH TPTNCYLLSL AVADILVLLS ATLPAIPEPF FQIDEWRFGR
VLCSLLIFLQ YLGVDASSAS ITAFTVERYF AICKPMRAQT MCTVNRAKKI IVGIWILTTI
YCSPWLGLTD LRRVQQTDGH IIEKCDFRLS RSSYLAYFMT DLVIFYVIPF IISAVLYCLI
GRILFSDSLN ISRGDNRSDI HAKRHSQARV QVSYSERLTI ITIPFFPLFQ VVRMLFVVVL
VFATLWMPYR VIVVYNSFAT NKYMDLWFLL FSRSMVYINS AINPILYNAM SVKFRRAFRN
HLCCGRYIFY NFKT
//