GenomeNet

Database: UniProt
Entry: V4A7L7_LOTGI
LinkDB: V4A7L7_LOTGI
Original site: V4A7L7_LOTGI 
ID   V4A7L7_LOTGI            Unreviewed;       374 AA.
AC   V4A7L7;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   RecName: Full=Thyrotropin-releasing hormone receptor {ECO:0000256|ARBA:ARBA00018873};
DE   AltName: Full=Thyroliberin receptor {ECO:0000256|ARBA:ARBA00032251};
GN   ORFNames=LOTGIDRAFT_122499 {ECO:0000313|EMBL:ESO91015.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO91015.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO91015.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- FUNCTION: Receptor for thyrotropin-releasing hormone (TRH). Upon ligand
CC       binding, this G-protein-coupled receptor triggers activation of the
CC       phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
CC       {ECO:0000256|ARBA:ARBA00004100}.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       {ECO:0000256|RuleBase:RU000688}.
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DR   EMBL; KB202284; ESO91015.1; -; Genomic_DNA.
DR   RefSeq; XP_009058286.1; XM_009060038.1.
DR   AlphaFoldDB; V4A7L7; -.
DR   STRING; 225164.V4A7L7; -.
DR   EnsemblMetazoa; LotgiT122499; LotgiP122499; LotgiG122499.
DR   GeneID; 20232113; -.
DR   KEGG; lgi:LOTGIDRAFT_122499; -.
DR   CTD; 20232113; -.
DR   HOGENOM; CLU_009579_6_5_1; -.
DR   OMA; TIITCGY; -.
DR   OrthoDB; 3471593at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004997; F:thyrotropin-releasing hormone receptor activity; IEA:InterPro.
DR   Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR002120; TRH_rcpt_1.
DR   PANTHER; PTHR46061:SF3; THYROLIBERIN RECEPTOR; 1.
DR   PANTHER; PTHR46061; THYROTROPIN-RELEASING HORMONE RECEPTOR; 1.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00751; THYROLIBRINR.
DR   PRINTS; PR01846; TRHRFAMILY.
DR   SMART; SM01381; 7TM_GPCR_Srsx; 1.
DR   SUPFAM; SSF81321; Family A G protein-coupled receptor-like; 1.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   3: Inferred from homology;
KW   G-protein coupled receptor {ECO:0000256|RuleBase:RU000688};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Receptor {ECO:0000256|RuleBase:RU000688};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Transducer {ECO:0000256|RuleBase:RU000688};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU000688};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        47..73
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        85..106
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        126..150
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        170..188
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        223..245
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        285..306
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        326..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          65..347
FT                   /note="G-protein coupled receptors family 1 profile"
FT                   /evidence="ECO:0000259|PROSITE:PS50262"
SQ   SEQUENCE   374 AA;  42988 MW;  3A99B7558EC4115A CRC64;
     MNQSEFINDT LQVLFSHHGA APPLSENETF IMENHTLLRP THYSTSFQLI AATISAIIFI
     VGLIGNVLVV IVIARTRSMH TPTNCYLLSL AVADILVLLS ATLPAIPEPF FQIDEWRFGR
     VLCSLLIFLQ YLGVDASSAS ITAFTVERYF AICKPMRAQT MCTVNRAKKI IVGIWILTTI
     YCSPWLGLTD LRRVQQTDGH IIEKCDFRLS RSSYLAYFMT DLVIFYVIPF IISAVLYCLI
     GRILFSDSLN ISRGDNRSDI HAKRHSQARV QVSYSERLTI ITIPFFPLFQ VVRMLFVVVL
     VFATLWMPYR VIVVYNSFAT NKYMDLWFLL FSRSMVYINS AINPILYNAM SVKFRRAFRN
     HLCCGRYIFY NFKT
//
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