GenomeNet

Database: UniProt
Entry: V4AA46_LOTGI
LinkDB: V4AA46_LOTGI
Original site: V4AA46_LOTGI 
ID   V4AA46_LOTGI            Unreviewed;      5045 AA.
AC   V4AA46;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   07-JUN-2017, entry version 28.
DE   SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ESO90186.1};
GN   ORFNames=LOTGIDRAFT_123762 {ECO:0000313|EMBL:ESO90186.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO90186.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO90186.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
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DR   EMBL; KB202481; ESO90186.1; -; Genomic_DNA.
DR   RefSeq; XP_009059256.1; XM_009061008.1.
DR   EnsemblMetazoa; LotgiT123762; LotgiP123762; LotgiG123762.
DR   GeneID; 20232291; -.
DR   KEGG; lgi:LOTGIDRAFT_123762; -.
DR   CTD; 20232291; -.
DR   KO; K04962; -.
DR   OMA; EHMPNDT; -.
DR   OrthoDB; EOG091G00T0; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd00051; EFh; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13499; EF-hand_7; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00054; EFh; 2.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS00018; EF_HAND_1; 2.
DR   PROSITE; PS50222; EF_HAND_2; 3.
DR   PROSITE; PS50919; MIR; 3.
PE   4: Predicted;
KW   Calcium {ECO:0000256|PROSITE-ProRule:PRU00448};
KW   Complete proteome {ECO:0000313|Proteomes:UP000030746};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4368   4398       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4569   4589       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4653   4676       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4844   4867       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4921   4944       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       91    145       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      204    257       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      263    324       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      426    443       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN      582    784       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      999   1198       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1405   1626       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     4125   4160       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   DOMAIN     4162   4195       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   CA_BIND    4138   4149       {ECO:0000256|PROSITE-ProRule:PRU00448}.
FT   CA_BIND    4173   4184       {ECO:0000256|PROSITE-ProRule:PRU00448}.
SQ   SEQUENCE   5045 AA;  570358 MW;  A18210202EA3812D CRC64;
     MIISDHILFI LQDDMVCLSC AVSSTKDASA TERVCLAAEG FGNRMCFLED VSNRDVPPDI
     SVSVFVLEQA LSVRALQEMI TSTSEGSASG HRTLLYGHAV LLRHHHGNMY LSCLSTSSSN
     DKLAFDVGLQ ETAEGESCWW TIHPASKQRS EGEKVRVGDD LILVSVSSER YLHIGSSNSI
     VASFQQTLWT VVPMCSGAVR TKTVGYVFGG DVLRLFHGQD ECLALPEAGS ENEFSAVMYE
     TGAVCSHARS LWRLEHIRTK WAGGFMGWGQ QCRIRHVTSG RYLAVTAGDH HVVTVHRHKA
     DEASTAFYMR QTKDDKKQSE VREAEGMGMA DIKYSDSMPF LQHCDSSLWL SYQTFETKKR
     GVGRVEEKKA IMLVEGHMDD GLTLAKSQEE ESRSARVIRK CQSLFNRFNK ALDSLKTEGR
     NSHAWGRISL AEVIKCLEDL IDYFAQPAED EEHEEKQNKL RALRNRQDLF QEEGMIALIL
     ETIDKFSQYK GQRQFSHYAG EDAGESWDSI SSYLYLLLAA MIRGNRANCA QFAQSYRLDW
     LVYRLESQQS STGVLDVLHC VLIDSPEALN MIKEKHIITI ISLIDKHGRD HKVLDVLRAL
     CVGSGVAVRT NQNLICDNLL PGRDLLLQTK LVDHVTCLRP NLCVGLCEGS AMYKKWYYEI
     VVINYEYATH LPPILRMGWA NTDGFKPYPG GGEKWGGNSI GDDLYSYAFD GQNLWTGKSA
     SQPLQKGDVI GCTLDLTVPQ ITFSLNGVKI RGFLKDFNLS GIFFPVVSMS AAVSCRFVFG
     GENGRLKYGP PEEHSPIIEC LMPKEKLHLT SCFHFGDLKK SIVSGPTEIL DYVPFVPSPV
     TTGRIQLPAY IENVRDKLAE NLHELWAMSK IEQGWSYGEE RNPTNKKNPS LTAFERLPMS
     EKKYVITVAF ETLRTLIALG YHITVDHQQQ QNNRLKTVKL ANNFLQNNGY KPTPLDLSVV
     TLTEKMEQLV NLLAENTHNV WARDRIKHGW TYGLKEDPIH KRSPHLVPYN KVDESIKKAN
     RNTTSDTVKT LIAYGYNLEA PTSETGETAL TRESQEKTIQ TRTYRAELTY AVTSGKWYYE
     MDVLTTGYMK IGWAKRSAQS GDELGLDGKS YVFDGYLARK WNQGSDAYGK IWQVGDVIGC
     MLDLHDKTIS FSLNGELMMD SLGQEIAFRD IDPAEGFVPA MTLGAHQSGR FNFGQDVNTL
     KYFTCCGLQE GYEPFCVNMT RQLPLWYSKE QALFCSLETD DPQIQITRIP GGANVTPCLK
     VQSKTFGTLE KVKLEFFRLS LPVRCRDEFL SILYLQSRYF SIHLSFNRVF GENDKSAAAK
     RKNYRQSMSQ GKGHSLDDTS IGDHSTTSGT MKTAASESHL NVDGSFLSLP NKGNNGSKLS
     LLADKVVGKA KAAVVDKKKD KKKSAGKPSF TSIFRKSKSR DPSPSNLKPR STRSTEYSSL
     DRKVSTSKAM RDHRRSPMKG NNGHSDAEMN EMNAIAEQIE EYHYSVRIFP GQDPSQVFVG
     WVTPDYHFHD TTFDTKKIRH VIVSTLDVDY RLKHSVSRKN CYIVSAGDLQ QRYAGANQDV
     SGKRSSPGLV IGCLVDCATG LLSFTVNGKE VANKFQVEPG TRLFPAVIAE STIKEMFQFE
     LGNTRTSLPL SAAVFRGPKS IQPMCPTRLD VQILKTSSWA RVPNISLGVQ TLKLSDIRGW
     SMLCENPVPM LAVYIPEEDR CLDVLELIEY EHLLNFHAKT LELYQAVCSH GNHRVASVLI
     QHIDERQLMY CIQSESLSGT LRNSFNDLLI SMHLDSHSKA RVITEKEFII PLLPQSKNLC
     LYRTRSPGSE DYNIKHQIPT MEDSVSIRPM LAITGKEIEN RFVYGKDSTA PYFPMAKLKA
     YTMRALTQAV QVGAAHIRDP IGGTNANLFV PLLKICDHLL TMGLLDDDDL NQLLCLLDPK
     IFDDHQMNMI GSNGLLNMTL SEPVKLEVCH ILQHLCAIQL RHRVETISSF SENFVGNCQN
     DQLRRYNAIK QADLPSSVTA KKTKEFRCPP QEQMRALLAF KEEEPVEGVE PCPCDEDICD
     LLRTFHIELR KHCAMPTLVE EEVPVDAPPQ PSVKEKLLAL VWKVKNDNHG LSGSRFKKPG
     KPDSIQKLVT DTVVRWAQED FISSADLIRE MFSLLHRQYD GIGELMAALE KTYVISCNSA
     NDINLLWKSL GIIRSLLLVQ VGHAEEELLK NSLRDLMDNK VFFQHPDLMR ALCVHETVMQ
     LMVNTLNKAQ QQQQAAASSA EATGGRQSIP TSSTSDTEMV VMCCRFLCYF CRTSRQNQRA
     MFEHLSYMLE NSSMLLARPS LRGSCPLDVG CSSLMDNNEL ALALREAHLE KIAIYLARCG
     LQSNSELSEK GYPDVGWDPV EGERFLDFLR FCVWVNGESV EENANLVVRL LIRRPECLGP
     ALRGEGGGLL RAIKEGIRMS EQIAASRDES SSNFLAAMND DDDTDDEDYI DMGGAIISFY
     ASLVDLLGRC APDAETIKAG RSDSVRARAI LRSLVSMEDL EGVLSLRFIL PVADPNAAEE
     DGGSGLPPGL LPAHKSAIVL FLERVYGVDD QTTFFRLLED SFLPDLRAAT TLDTAAASES
     DMALALNRYL CTSVLPLLKD NSQYFNNADH ASPLLDSTLH TVYRLSKCRT LTKNQQETVS
     DFLVSFTQQL RPPLMTRLLK KLTIDVPALS EHAVVPLRLL TYHYERCGRY YGSGGGWGSH
     GSASEEEKRL TMMLFSGMFD SLAKRAYDPE LFSKALPCLS AIGCALSPDY TLSHNADSWY
     GQSSVDIDGT YTPQPVTTTR VNLNQQLENT TSKFAEHFHD SWALKKIESG WIFGSRFDEE
     KKTHPILKPY NLLDERVKSK YTTPMKETLK AMIAWGWTLE QDQSRFSTNR DSIKRRASKA
     NVVRDGPLKH DHGYSPKPYD LRNMTLTREM QTMAERLSEN AHDLWAFKKK VELDSIGGGV
     HPQLVPYDIL TDTEKRKYRE HAQEALKFLQ FLGYRISRNS RESEADSGVG VSATERRFAY
     SLLEKLLEYL EKASVNLQQI QPSSRFSRRE SYNVATEDVK FFGKVVLPFV ERYFHAHRIY
     FISAPHTPQA ASGSASFKEK EMTASLFCKL AQTLRSKITA FGHDVNISVR CLRVLVQAVD
     FRSVVKNSPE IVRSSILPFF NNAADDLAQI MENLQKGRFS HVKGTITRGA TSLNYVHMVL
     LPVMSAILDH FGNNDFGFDI IVGDIQLACY RILNALFTLG TSSSSFPQRE TIEAELARHR
     PALGECVGSF ASCFPVAFLE PDLNKYNKNS ILYGIEGKIS EHSLEAQEVM DMLAVNLPTL
     NKIVAEIEGL ADSGGKYHEA PHVIEVTLPM VCSYLPVWLT KGPDCISRPE GGHHISSVTG
     QQMNNVLGNV LKLILNNIGS VDAPWMNRIA ARTQPIISNS TPDMIKDHFL PIAKKLCEHA
     VLVESLEKRL AVDKRTSTDI SDMEAAVQDR YGILVRDIYA YFPLLIKYVD LHRSHWLKYP
     AAEAEELFTC VADIFSMWSK SLLFKREEQN FVALNEIDNM ALIMPSQAKH LSVAKVDTSE
     ESPTTKMKPG QKRQGKKRLE PHNSLNVACL KRLVPIGLSF FSGREQELLQ QAKQKLLQRY
     KNIDTMAVTF LSLFTYSCFR FQPIDDKVQW QKVLYKKIGD TKTSTAQLDQ SKVIDRIISM
     AKVMHGLHLV EHPSLAQRSA WKKLISTQRK RAVMACFRMI PLHSLPRHRA INLFLKAYRE
     MWLETEELDK TILIQDLTKG DETVEEGEKN ETEEECKPDS LTQLITALSR AATKEQQSSL
     PEDPLFMSYA SIMMRKCDNL MFLVSFKLVY LLSIVHNEQE MEKQQLLSEQ SRLSDRGAAE
     MVLLYISASR GEFNMMVENT IDLGISLLRG GNIEVQKRML RHLKDKKDVG FFSSIAGLLE
     KCSVLDLDAF ERTNKAEGLG MSTDTGSTDQ NLHDGEFTCK IFRFLQLMCE GHNLEFQNYL
     RTQAGNTVTV NVVICTVDYL LRLQESMMDF YWHYSGKDVI DVSGKDHFCR ASMVAKQVFC
     SLSEYIQGPC SLNQLALAHS RLWDAVGGFI YIFAHMQDKL SKDPDQLDLL REFMELQKEM
     MIMLLSMLEG NVMNGPIGKQ MVDTLVESSS NVEMILKFFD IFLKMKDLTS SEAFLEFDTN
     QDGWISHKEF RKAMESQKVY TEEEIQYIMM CVDANHDGKV DFHEFTDRFH NPAKDIGFTM
     AVLLTNLSEH MPNEPRLGRL LEKAKSVLDY FEPYLGRIEI MGSANRIERV YFEITQSHID
     QWEKPQIKES KRSFLHSVVN EGGDKEKLES FVNFCEDSIF EMQHATSISA EEQRIAALKS
     GGFGGEGGVL EPISITYRFF KDLLFSFFSF FTWTNIKKSY SAFKSMTYWQ VFVALIKLTF
     KLSFMTICFG FNIVWTLLKF FINMMMGDKS EEEAKQRQKE KELAAAAEAA KLAPLALGPP
     GIPLTPIKID PIEINRSDTD TDKKSNGLPS NGSVTNVEAG TPPAATSENK STTTKADLET
     QYMELEEDEA FFQESVEENQ QPLLQASTQN VYQPDMSGGQ HVDKNRTLLN WIDKKQTVFL
     FQSLFARNFY NFKFMALVLA FILNCMLLFY KVRFFCLTVS VLFANSLLWW WNETITVSTK
     TEEGAAGNET AEGGDEDIAE IVTMEDDKTY LEYVMTGLAF LHCLLSLSIL IAYYCLKVPL
     VIFKREKEIA RKLEFEGLYV AEQPGDDDLK AQWDRLVLST RSFPESYWDK FVKKKVRSRY
     AEQYDYGAIS GLLGMEKQNV HKETTAPTKS YLPAFLSNVD FQYQIWKWGA IFTDNAFLYS
     AWYFLFSVLG NFNYFFFAAH LLDVAIGIKT LRTILQSVTH NGKQLVLTVM LTCVVVYIYT
     VIAFNFFRKF YVKEEDGQVD QKCHDMATCF VYHLHTGVRA GGGIGDEIEP ADGDPYEVYR
     ILFDVTFFFF VIVILLAIIQ GLIIDAFGEL RDQLEQVKED MESKCFICGI GKEYFDKVPH
     GFETHVKNEH NFANYMFFLM HLINKPDTEH TGQESYVWEM YQQRCWDFFP VGECFRKQYE
     NELGI
//
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