ID V4AAG8_LOTGI Unreviewed; 889 AA.
AC V4AAG8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Pyruvate dehydrogenase phosphatase regulatory subunit, mitochondrial {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_233822 {ECO:0000313|EMBL:ESO90301.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO90301.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO90301.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SIMILARITY: Belongs to the GcvT family.
CC {ECO:0000256|ARBA:ARBA00008609}.
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DR EMBL; KB202444; ESO90301.1; -; Genomic_DNA.
DR RefSeq; XP_009058974.1; XM_009060726.1.
DR AlphaFoldDB; V4AAG8; -.
DR STRING; 225164.V4AAG8; -.
DR EnsemblMetazoa; LotgiT233822; LotgiP233822; LotgiG233822.
DR GeneID; 20249364; -.
DR KEGG; lgi:LOTGIDRAFT_233822; -.
DR CTD; 20249364; -.
DR HOGENOM; CLU_007884_11_0_1; -.
DR OMA; TKFPDRE; -.
DR OrthoDB; 1815533at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR Gene3D; 2.40.30.110; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.70.1400; Aminomethyltransferase beta-barrel domains; 1.
DR Gene3D; 3.30.9.10; D-Amino Acid Oxidase, subunit A, domain 2; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR006076; FAD-dep_OxRdtase.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR032503; FAO_M.
DR InterPro; IPR013977; GCV_T_C.
DR InterPro; IPR006222; GCV_T_N.
DR InterPro; IPR029043; GcvT/YgfZ_C.
DR InterPro; IPR027266; TrmE/GcvT_dom1.
DR PANTHER; PTHR13847:SF193; PYRUVATE DEHYDROGENASE PHOSPHATASE REGULATORY SUBUNIT, MITOCHONDRIAL; 1.
DR PANTHER; PTHR13847; SARCOSINE DEHYDROGENASE-RELATED; 1.
DR Pfam; PF01266; DAO; 1.
DR Pfam; PF16350; FAO_M; 1.
DR Pfam; PF01571; GCV_T; 1.
DR Pfam; PF08669; GCV_T_C; 1.
DR SUPFAM; SSF101790; Aminomethyltransferase beta-barrel domain; 1.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF103025; Folate-binding domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 54..411
FT /note="FAD dependent oxidoreductase"
FT /evidence="ECO:0000259|Pfam:PF01266"
FT DOMAIN 414..469
FT /note="FAD dependent oxidoreductase central"
FT /evidence="ECO:0000259|Pfam:PF16350"
FT DOMAIN 471..749
FT /note="Aminomethyltransferase folate-binding"
FT /evidence="ECO:0000259|Pfam:PF01571"
FT DOMAIN 774..864
FT /note="Glycine cleavage T-protein C-terminal barrel"
FT /evidence="ECO:0000259|Pfam:PF08669"
SQ SEQUENCE 889 AA; 100520 MW; CE5C9E8BF80BCF0D CRC64;
MERQARMMMR TLSCLRQHNV RTSIRSLGGA TRQYSTDKGQ TLEREAVALP KHARVVIAGG
GIIGPSVAYH LTERGWTDVV LLEQGSLTCG TTWHSVGMIG QLRANYPEME ACRISRNLYA
RLEEEGHGLG WKPCGGLNLA RTKDRWTEFK RKHSMASAIG LETHLLSPKE IEKLVPLIKT
DDLIGGIWLP SDGAVTAPDV SMALMRIARE RGAKFMEGVK VEKILTKNGR VTGVETSAGN
IDCEYFVNCA GQWAREIGKS TTPKVRVPLH SCEHFYLVTK PLEEVDRLMP GIRDYDGYTY
SREWNGGLLA GGFEPVSKPC FHTGVPDKFE FQLLQEDWDH FQILLDQILL RYPIMEKAEI
RQLVNGPESF SPDANWILGE TAEVDNYYVA AGLNSRGVVG GGGVGHYMAE WIIDGKPSIN
LWQFDVRRFV DHHNNRRFLY ERVKEVLGSV FGLRYPKEDF TRGRKLRTSP LHTRLENAGA
MFGETMAYER PMWFDPDKRD RGEDSYIHQG SYTKPAWFEF TQDEYWACKE RVCLIDMSNF
AKFEIKSAGN EALEYLQYLC SNNIDLEKGT IIHTGMQNEQ GGFENDCSIA RLGNNNFFMI
CPATQQTRAL SWLRRHLPAD GSVQVSDVTS MYSGINVMGP HAQALLGDVT DVSTQKKDFK
VMTCRFIDVG NASGIRAMRL THAGEDGFIL YIPSEYALHV YDTLMTAGTD YGIRNAGYYA
IRHLRVEKSF AYWGLDLDEH TTPLECGREF RVKFDKDFIG KEALQKQRKE GVSRKFAQFM
LEDFDVETDI WPWGDEPIYR NGVKVGSTTT CGYGFTLERM VCLGFVSDLD QNGNPKINPQ
INDYVMDKEA VYEIDISGKR FKAKPGIHTP KLALSSVDPS LLAFIQKDT
//
