ID V4AFE9_LOTGI Unreviewed; 673 AA.
AC V4AFE9;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE RecName: Full=Helicase C-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_202330 {ECO:0000313|EMBL:ESO95607.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO95607.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO95607.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
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DR EMBL; KB201613; ESO95607.1; -; Genomic_DNA.
DR RefSeq; XP_009053698.1; XM_009055450.1.
DR AlphaFoldDB; V4AFE9; -.
DR STRING; 225164.V4AFE9; -.
DR EnsemblMetazoa; LotgiT202330; LotgiP202330; LotgiG202330.
DR GeneID; 20245524; -.
DR KEGG; lgi:LOTGIDRAFT_202330; -.
DR CTD; 20245524; -.
DR HOGENOM; CLU_000335_0_3_1; -.
DR OMA; HEGLNLM; -.
DR OrthoDB; 57056at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0034641; P:cellular nitrogen compound metabolic process; IEA:UniProt.
DR GO; GO:0043170; P:macromolecule metabolic process; IEA:UniProt.
DR GO; GO:0044238; P:primary metabolic process; IEA:UniProt.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR24075; SEC63 DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR24075:SF5; U5 SMALL NUCLEAR RIBONUCLEOPROTEIN 200 KDA HELICASE; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022806};
KW Chaperone {ECO:0000256|ARBA:ARBA00023186};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022806};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022806};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 141..229
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|SMART:SM00490"
FT DOMAIN 346..658
FT /note="SEC63"
FT /evidence="ECO:0000259|SMART:SM00973"
SQ SEQUENCE 673 AA; 76319 MW; B38A9870CBD2070D CRC64;
MRYISSQLER NIRIVALSSS ISNAKDIAQW LSCGTTSFFN FHPNVRPVPL ELHIQGLNVS
HNASRILAMA KPTYQAIVRH SPKRPVAVFV PSRKQTRLTA IDILTFAAAD MQPGPDDKPQ
STFLHVAESD LDPFLDKISD KTLKETLTNG VGYLHEGLSD REKKVVEQLF NTGAIQVVVV
SRNLAWGVNI TSHLVIVMDT QYYDGKTHSY EDYPVTDVLQ MIGKANRPLQ DKDAKAVILC
QSSKKEFFKK FLYEPLPIES HLDHCLHDHF CAEVVTKTIE NKQDAVDYLT WTFIYRRMTQ
NPNYYNLQGV SHRHLSDHLS ELVENTINDL EQSKCISIED DMDVTPLNLG MIAAYYYINY
TTIELFSMSL NNKTKIKGLI EIIASAAEYE NIPIRHGENN ILKQLATRLP NKLTNPKYND
PHIKTNLLLQ AHLSRMTLSA ELQSDTEDIL GKAIRLIQAC VDVLSSNGWL SPALAAMELA
QMCTQAMWGK DSYLKQLPHF TSEIIKRCKD KGHDTIFDIM EMEDDERNAL LQLNDSQMAD
VARFSNRYPN IELTYEVQDK EQIRSGSGIN VSVTLEREDE IVGPVIAPFF PQSREEGWWV
VIGDTKTNSL LSIKRLTLQQ KAKVKLDFVA PNAGHYNYTI YFMSDAYMGC DQEYKFTVNV
KEGDSDSDGS DSN
//
