GenomeNet

Database: UniProt
Entry: V4AKJ8_LOTGI
LinkDB: V4AKJ8_LOTGI
Original site: V4AKJ8_LOTGI 
ID   V4AKJ8_LOTGI            Unreviewed;      1977 AA.
AC   V4AKJ8;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 45.
DE   RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE            EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN   ORFNames=LOTGIDRAFT_170560 {ECO:0000313|EMBL:ESP04724.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP04724.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESP04724.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC         [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC         cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC         EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
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DR   EMBL; KB199652; ESP04724.1; -; Genomic_DNA.
DR   RefSeq; XP_009044623.1; XM_009046375.1.
DR   STRING; 225164.V4AKJ8; -.
DR   EnsemblMetazoa; LotgiT170560; LotgiP170560; LotgiG170560.
DR   GeneID; 20241454; -.
DR   KEGG; lgi:LOTGIDRAFT_170560; -.
DR   CTD; 20241454; -.
DR   HOGENOM; CLU_234325_0_0_1; -.
DR   OrthoDB; 443445at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0004386; F:helicase activity; IEA:InterPro.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR   CDD; cd20335; BRcat_RBR; 1.
DR   CDD; cd22585; Rcat_RBR_DEAH12-like; 1.
DR   CDD; cd00590; RRM_SF; 1.
DR   Gene3D; 1.20.120.1080; -; 1.
DR   Gene3D; 1.20.120.1750; -; 1.
DR   Gene3D; 3.30.70.330; -; 1.
DR   InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR   InterPro; IPR031127; E3_UB_ligase_RBR.
DR   InterPro; IPR007502; Helicase-assoc_dom.
DR   InterPro; IPR002867; IBR_dom.
DR   InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR   InterPro; IPR035979; RBD_domain_sf.
DR   InterPro; IPR044066; TRIAD_supradom.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR017907; Znf_RING_CS.
DR   PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR   Pfam; PF01485; IBR; 2.
DR   Pfam; PF07717; OB_NTP_bind; 1.
DR   SMART; SM00847; HA2; 1.
DR   SMART; SM00647; IBR; 2.
DR   SUPFAM; SSF57850; RING/U-box; 3.
DR   SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
DR   PROSITE; PS51873; TRIAD; 1.
DR   PROSITE; PS00518; ZF_RING_1; 1.
DR   PROSITE; PS50089; ZF_RING_2; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833};
KW   Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW   ProRule:PRU00175}.
FT   DOMAIN          1761..1977
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS51873"
FT   DOMAIN          1765..1814
FT                   /note="RING-type"
FT                   /evidence="ECO:0000259|PROSITE:PS50089"
FT   REGION          45..64
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          94..250
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          418..481
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          535..737
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          1543..1570
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        49..63
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        98..131
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        132..151
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        152..216
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        217..247
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        419..463
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        538..567
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        568..594
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        595..654
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        683..733
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1977 AA;  225519 MW;  3B9FC9402F4365FA CRC64;
     MDRILPEFLK KLWRNHNNGD RDKADPEEGR DCTKIDIFDN VLFDPLPART PSSDQQTNGS
     DIKNVAKSHD KIVIAETRNK YDWKILPYPK ESTNKFKSDG RLTTPSKQSS FRQYDPSASS
     RYRPTLMSES PTELDRTERR REHRETLKDS YPNKQFDGQN IPIKPRSTLD NKAKPALSTN
     SFTKNEVGLP HQSRENRGTQ NGSLSSRSFG SSDLSNDEEA RLQHTREVLK RTTDKIRKSE
     SKESKTCTDY PGIRLSSTSF GSCNISNDKV ATLQHRRDVL KRDTGQIRKS DRKESTLCRP
     SAYPVVPKRN EFCDESKKNT KCPMTQYDHL SSTTRLSFES SDGTDVDTSK SRVNYIKMIS
     PRPFIYRQSN SLENKTAKES GNGSSSTKVI DTYTKKIHDS RDGYQQFNME TSTVDTKYKG
     VATDKRTPTD KQPIVDKQPL VDKRPPVDKG NATDKRKPVD KQPVDQRTSA NDSSEIDKYT
     KKNHSQLDKL LSDCVEKSRN DCLKKSGKLC DAENAGEHSL STLEIGTLAK YHSQGARPKD
     SSFINKSKNM SPNLAETSGG RNDVKGLEPT SQHTKFDTRQ EANDHSKRSK NNETLNLDQS
     KVKSANPDLT ENSRRQSYVN RKSETNQKAS HKIIAATASE QKGSTSLHER NNSLNQDQSK
     SKKKRNRRRR KSNNHEATKD NHHVTSATPL RQPEIGNSQP LERSQSSSQN QSRSNVVKNP
     KKPETTPINP TIIQDKPIPS KVHLTNHFQK IATCPKSKPS RSFYVVLLKI EMSVPLVALL
     DIILGPDSER TILSIEDEPI LDLESATLNF SDVQKAEQAL KQLREFNCQN LLCTWTTVDK
     RIEILKTYFN DFEFHSSDIL KTHDEKIQAI RKQLESCAFD EKEALKMRKE ELILQLREFT
     SFSKTVRESL RRSILLEDEQ SPPDAAIQTA IETLEELGSI KDDRITDIGK WLVKIPLEPR
     FGCMIKKGFE MGFAYDTIVF TALCSSSGSI FYRGGNDQQK KRSDLKKLTF CDTKGDAFTY
     LKIYKEWEQV TEKRKNKWCF DNALNSKSLR GARELVNEIC SIFKHNWSIL VKKTFSTKVE
     LEEALQNIIL FAFYENIAHS LGHNRMGYYI PNLRQRVFVH PSSALNSLND SSQWLVFINI
     LKTSRDYITV VTPVEESWIR KITSLKTKQF DIDEAKRKSV CSVRNQFFGS TTYSFFVGPA
     HSKLKAYEDL LYESVQVPVV IEADRKTGEV KFICGFNVAL PGDLIDNWIV EARSHVIQRT
     AEYKVGSNNQ AGGVRIVLGL GGEGQLILMP DEYRNIHIKS SGKETSKETV VDKFKRFGQI
     VDCWEDKRSY HRWGRVTFST PEAAAEAVRR TQDDPKHAAT PEFKIQKHAF FQYQATIEWV
     RRKPTGLVFV DMDYLEAMSV KSLREVRILG QSCSISLDKK KRGTVLLRKV PTMVTEQDIQ
     YCFPQHSQRR AITKISIIRE KTFTNPNEIP YFQQQIHDQF QEFDHDMKFV VDVMKPYDSN
     INFRAFIKFN DASQGTMACD ALRGRLIING QKANLTPKLS SSLSVSEQVY QLLEDEIEDF
     TAELRENGTE FKLDSKKLKN ERRVFNISAS NSNDLVQIRL GLAAIVQGEV IEYWSNENNR
     YLFLKSGREF LRSLEKRTNT ILQVDNRLLS LRVFGLEDNI LMAQNAIDQY LGNMVEGDGR
     REIKLDGKSQ PKGLMKTLVT RYDLELEGFV QASGLQSALL NHHNQTLKIS GDSASIEKAT
     GLIESLATEL RNKITKTKIA ELPDCCTCLC PVQSMDYIYR LEACGHVYCL DCIKRQITVA
     VQSKELPVLC GNCQDPLVWS DFEFCFKRLQ INPLDLVRTA VSVYMIRNKD GYRHCPTPDC
     PMVYRITKKS DVFNCNECGM RICTSCHVEY HDGLTCAMLK SSSDVDSDME KYLRENATRV
     KRCPKCSTPI EKKSGCNHMT CSGCKIHFCW LCCQAFTTTS SVYGHLNAQH GGIFDFR
//
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