ID V4ANK8_LOTGI Unreviewed; 577 AA.
AC V4ANK8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Transcription initiation factor TFIID subunit 6 {ECO:0000256|ARBA:ARBA00040091};
GN ORFNames=LOTGIDRAFT_175212 {ECO:0000313|EMBL:ESO95221.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO95221.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO95221.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBUNIT: The nucleosome is a histone octamer containing two molecules
CC each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and
CC two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of
CC DNA. {ECO:0000256|ARBA:ARBA00011538}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the TAF6 family.
CC {ECO:0000256|ARBA:ARBA00007688}.
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DR EMBL; KB201671; ESO95221.1; -; Genomic_DNA.
DR RefSeq; XP_009054086.1; XM_009055838.1.
DR AlphaFoldDB; V4ANK8; -.
DR STRING; 225164.V4ANK8; -.
DR EnsemblMetazoa; LotgiT175212; LotgiP175212; LotgiG175212.
DR GeneID; 20243078; -.
DR KEGG; lgi:LOTGIDRAFT_175212; -.
DR CTD; 20243078; -.
DR HOGENOM; CLU_021711_2_0_1; -.
DR OMA; MPEETCQ; -.
DR OrthoDB; 1529at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0000124; C:SAGA complex; IEA:InterPro.
DR GO; GO:0046695; C:SLIK (SAGA-like) complex; IEA:InterPro.
DR GO; GO:0005669; C:transcription factor TFIID complex; IEA:InterPro.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0016251; F:RNA polymerase II general transcription initiation factor activity; IEA:InterPro.
DR GO; GO:0006367; P:transcription initiation at RNA polymerase II promoter; IEA:InterPro.
DR CDD; cd08050; TAF6C; 1.
DR Gene3D; 1.10.20.10; Histone, subunit A; 1.
DR Gene3D; 1.25.40.770; TAF6, C-terminal HEAT repeat domain; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR037796; TAF6.
DR InterPro; IPR011442; TAF6_C.
DR InterPro; IPR046344; TAF6_C_sf.
DR InterPro; IPR004823; TAF_TATA-bd_Histone-like_dom.
DR PANTHER; PTHR10221; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6; 1.
DR PANTHER; PTHR10221:SF9; TRANSCRIPTION INITIATION FACTOR TFIID SUBUNIT 6; 1.
DR Pfam; PF02969; TAF; 1.
DR Pfam; PF07571; TAF6_C; 1.
DR SMART; SM00803; TAF; 1.
DR SUPFAM; SSF47113; Histone-fold; 1.
PE 3: Inferred from homology;
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 13..77
FT /note="TATA box binding protein associated factor (TAF)
FT histone-like fold"
FT /evidence="ECO:0000259|SMART:SM00803"
FT REGION 465..577
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 465..566
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 577 AA; 63456 MW; A1EFE54995DFC3DC CRC64;
MSHSSEKEGK VVGNLSGESM KTIAESVAIN GVGDQAAGFL AEDCTYRLKQ LVQESIKFLQ
HGKRRKLTTN DFDMALRSNN IEPLYGFHTP DLIPFRFASG GGRELYFNEE KELDLQEVIN
TQLPKIPLDV SLKAHWLCID GEQPAIPENP PPATKDQQKL QSLDTSIKSQ IDKVNKPKTS
SEGKSTRLKL KGADMVKLKD ISTHELSVEQ QLYYKEITEA CVGSDETRRS EALQSLATDP
GLHQMLPRYS SFISEGVKIN VVQHNLALLI YLMRMVKSLM DNQTLFLEKY LHEMIPGVCT
CIVSKQLCLR PDVDNHWALR DFAARLMAQI SKNYSTNTNN IQARTTKMYT QALQDERSAL
ATQYGAVAGM GELGAEVIKT FLLPNLKLLG ERLKTAIEGP IINNVDKIAS DHIKKLLTKY
LPSVLKTVHS VSETVEDYTK EYGYLGPGLH TSVIKERTTI VTQTPVSKPS LNIQQSGTPT
TPRFPSASVV PRTPTTPNIP HQQKYVIMSS QGRSSTGTQP TSLSLPTSSS STSSSTPTIV
KLVSNSNQPP PAPSSSAATV QGPSGQKYVV MSLPKDG
//
