ID V4ART3_LOTGI Unreviewed; 1257 AA.
AC V4ART3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE RecName: Full=Nidogen-1 {ECO:0008006|Google:ProtNLM};
GN ORFNames=LOTGIDRAFT_208735 {ECO:0000313|EMBL:ESO97555.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO97555.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO97555.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC Secreted, extracellular space, extracellular matrix, basement membrane
CC {ECO:0000256|ARBA:ARBA00004302}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB201304; ESO97555.1; -; Genomic_DNA.
DR RefSeq; XP_009051417.1; XM_009053169.1.
DR AlphaFoldDB; V4ART3; -.
DR STRING; 225164.V4ART3; -.
DR EnsemblMetazoa; LotgiT208735; LotgiP208735; LotgiG208735.
DR GeneID; 20246084; -.
DR KEGG; lgi:LOTGIDRAFT_208735; -.
DR CTD; 20246084; -.
DR HOGENOM; CLU_003163_1_0_1; -.
DR OMA; TQTHPIQ; -.
DR OrthoDB; 25347at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005604; C:basement membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR CDD; cd00255; nidG2; 1.
DR Gene3D; 2.40.155.10; Green fluorescent protein; 1.
DR Gene3D; 2.10.25.10; Laminin; 10.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR006605; G2_nidogen/fibulin_G2F.
DR InterPro; IPR009017; GFP.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR003886; NIDO_dom.
DR PANTHER; PTHR46513:SF34; NIDOGEN (ENTACTIN); 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF12947; EGF_3; 2.
DR Pfam; PF07474; G2F; 1.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR Pfam; PF06119; NIDO; 1.
DR SMART; SM00181; EGF; 12.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00682; G2F; 1.
DR SMART; SM00135; LY; 5.
DR SMART; SM00539; NIDO; 1.
DR SUPFAM; SSF54511; GFP-like; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 3.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS00010; ASX_HYDROXYL; 1.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 8.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS51120; LDLRB; 3.
DR PROSITE; PS51220; NIDO; 1.
DR PROSITE; PS50993; NIDOGEN_G2; 1.
PE 4: Predicted;
KW Basement membrane {ECO:0000256|ARBA:ARBA00022869};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022869};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022869}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..1257
FT /note="Nidogen-1"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004717430"
FT DOMAIN 94..244
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 310..535
FT /note="Nidogen G2 beta-barrel"
FT /evidence="ECO:0000259|PROSITE:PS50993"
FT DOMAIN 530..570
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 571..611
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 613..651
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 653..694
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 737..775
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 814..856
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 858..899
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 903..943
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REPEAT 994..1035
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1036..1078
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1079..1123
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DISULFID 663..680
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 744..761
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 868..885
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1257 AA; 139747 MW; DFD2ABDAD4B56855 CRC64;
MAPLYLALCM ISLVHGVPLR LFYSYGENAR NNVTLNVGDD VSSDEVTLNT PIAFYENYYR
NVYINVNGHL SFETELPDYR ATLVLPIGFK IIAVYLSDVD TRGTGKVYYR ETQDKSSLQR
AALDIQTHFT GQESFEPTSL FIVTWDKVGY YKQGTDKTNT FQLVIASDGR DSFAIFNYLD
NGMGWVTGDG KTTPSLPDVP AQAGFDSGER QRFVKLPNSG TTTSYVNDTN VNVPGSWMFH
IGNTGGSNIA SADLNTGEVV IFEVDQEQSC LEGARQCHIN AKCVDFDSGF CCECQKPYYG
NGRQCLEPGV PQRLNGKVFG TVNGYRLQDL DQHTYVVTSD GRAYTAISRV PPELGVGLQT
LNTLGGVIGW MFATQIHPSA KNGYAFTGGE FNRTVTVTFF DQNNEKKLRI YQYFFGHDAL
NNMRMESRLD GVIPQIPIDA KVSVDDYKEN YKKVAPGVIK SFSTRTYRIN EVAYRYTWDQ
TIYFKECMND PMKDEGEITQ LSITRSFVVY NEQDQVVRYA GSNKVGVYAG QDPCSNAAQN
CDSNADCIPV GESYRCACRV GYGGDGVTCQ DVDECSFELN TCDENARCFN VPGSFQCQCE
NGYLGDGIIC RPDLEECGGR YCDVNAICSD RRGRPMCECK SGFAGNGIEC YPVEFGCNEA
DICGENAECI FDNDDGKYRC ECMDDFSGDG IVCEPTRGRI DCEKCDSNAQ CNYDVERFVF
RCQCNAGFTG NGYSCSPLDD CSLCDPNADC LFDRTENKNR CYCRRGFYGD GNRCQRYDCQ
RQQVCDPNAD CVKDGEFNIC ECKSGFRGDG RRCVVAECNI VNNCDVNAQC IPDQRDTRRY
LCQCNPGYEG DGRVCIQRVV PCNQVNNCSP YAECLYNPDN LSYRCRCGSG YQGDGYQCRR
RTDLVDCNKN SSLCDSNASC LFLVDQYACV CNDKYRGNGA RCVPIVGKGN YLIYAQGYKL
MKTPHDSSEF TYGEQIVSDP EQLAIAVETD CKTGYLYWTD VYGGQIKRSN LDGSNSQVIL
DGLSSPEGLA VDYVSGNIYY TDSGLDVIGV SKLDGSAKST LFKQNLENPR SIVIDVSRSV
IYWTDWNRNG PKIERGSMDG SERKTIVETD LGLPNGLAID VTTQQLCWAD AGARKIECAR
SDGVGRRIIY DQAQYPFGLT FVDNVLYWTD WEKKQIISFN RDTGASGNLN LAPGGNGKLY
GITAVRNTCP QITNACSFNN GGCRFLCLPT PRGGRKCMCA DNVDPRRCNE IFNTSKK
//
