ID   V4ATU2_LOTGI            Unreviewed;      1048 AA.
AC   V4ATU2;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   27-MAR-2024, entry version 45.
DE   RecName: Full=Death domain-containing protein {ECO:0000259|PROSITE:PS50017};
GN   ORFNames=LOTGIDRAFT_158021 {ECO:0000313|EMBL:ESP00728.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP00728.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESP00728.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA   Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA   Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB200701; ESP00728.1; -; Genomic_DNA.
DR   RefSeq; XP_009048847.1; XM_009050599.1.
DR   AlphaFoldDB; V4ATU2; -.
DR   EnsemblMetazoa; LotgiT158021; LotgiP158021; LotgiG158021.
DR   GeneID; 20237599; -.
DR   KEGG; lgi:LOTGIDRAFT_158021; -.
DR   CTD; 20237599; -.
DR   HOGENOM; CLU_291396_0_0_1; -.
DR   OMA; VPLFCGQ; -.
DR   OrthoDB; 2970403at2759; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005525; F:GTP binding; IEA:InterPro.
DR   GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR032171; COR.
DR   InterPro; IPR011029; DEATH-like_dom_sf.
DR   InterPro; IPR000488; Death_domain.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR001806; Small_GTPase.
DR   Pfam; PF16095; COR; 1.
DR   Pfam; PF00531; Death; 1.
DR   Pfam; PF00071; Ras; 1.
DR   SMART; SM00005; DEATH; 1.
DR   SUPFAM; SSF47986; DEATH domain; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR   PROSITE; PS50017; DEATH_DOMAIN; 1.
PE   4: Predicted;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        133..156
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        189..206
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        218..235
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        241..258
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        278..295
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        361..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          973..1044
FT                   /note="Death"
FT                   /evidence="ECO:0000259|PROSITE:PS50017"
SQ   SEQUENCE   1048 AA;  119742 MW;  868FA7E380BB6D50 CRC64;
     MQAAEQKAIY QMSLTPGMAF ITGPEGRKAE QEAINYDTDT SYRLVVNIVG RERQGKTSLR
     KLLSNDPFNE HEESTVGVDH ELVDTTGLEP NPSLPWCKLD IRKANANEYD EILGKHVMIR
     LKRTEDKATK HRLAPLIVCI KICIITLLAL CFFIMCSNIH QTYWIPWFGI LMNLIFGVSS
     YTFGLTEGPG IAVGIRHLVV LTTAWFRWNL RSDLEFDHNW SVVFTTVILF VYVLALELFE
     SVFLGLSLGV GLLCYFCLCD SPEPEMYLTK CPVSDPGVLL LLLGCLVGLV LHNFWNRRVI
     TILATCLVVL CAYKPLWGIT LTLATCNGVL HNVGLKVGQN FYCNLNVYLS AMSSSTRGRR
     LFRHVLGLVP GAILATLYGW KLSVSIPRVL VVICIILELE FFAYLKAKAS KTVKENRSVN
     HPSKVISART KSPRLKLVVR DFAGHPLYYD AHHVYMTGQC VYLLVFSLVE AAVEFRKVYQ
     DIIQWLQSIR LHNRYPETRV FLVGTRRDDP KLSKCKVEEI AKELKRQLPR SYQNMLVWNH
     DDTPLFPVEN SIRNIHDTDH KNLREMITQQ TSDLTFRKEF PVKFFFFFNI IEHYRALNTL
     YDTFGNVVAL CREMGLWFKT DQEFSEMLNV FQRTGEVMFR NDDTNQCDLI IFDPKALLNI
     LCHIINIPRI SERSSHLVAD WSVLQDHGIC SMQLFDHIFE DHSKGNTKEH VIEALARFNL
     ICKISSIFLS EDVDSSISFL IPSCLPEVLP YQDLCWTECP EDQILYIKCQ PYFPQVLFSR
     LVCVCVSFDE SLMRDDSYPN VCKSKAVLTY RGKVCYQLEL IRDDQTGLYD LIKIVVRDDV
     KNSISPVVLA IWQCLSIIVK QDFKMCSLSL GVLCHLPPPH DGNYSNHLLP IITSTTGDIS
     SPNHCKSEFL CCGRKVKLRF DQILPIDNNN QKEVGLSNIS VDKHRVKNLR EQHILELPNH
     VFTTICDFLN PPNPLGHDWT LLAGLLGLTV TDVDMIRFKN SQNPCGAVLH IWCSRQPEVT
     LEVLTDLLAE MERNDVIETL ADLGFDTN
//