ID V4AV04_LOTGI Unreviewed; 3543 AA.
AC V4AV04;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Delta-like protein {ECO:0000256|RuleBase:RU280815};
GN ORFNames=LOTGIDRAFT_158756 {ECO:0000313|EMBL:ESO98805.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO98805.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO98805.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- FUNCTION: Putative Notch ligand involved in the mediation of Notch
CC signaling. {ECO:0000256|RuleBase:RU280815}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU280815}; Single-
CC pass type I membrane protein {ECO:0000256|RuleBase:RU280815}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00377}.
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DR EMBL; KB201205; ESO98805.1; -; Genomic_DNA.
DR RefSeq; XP_009050441.1; XM_009052193.1.
DR STRING; 225164.V4AV04; -.
DR EnsemblMetazoa; LotgiT158756; LotgiP158756; LotgiG158756.
DR GeneID; 20237865; -.
DR KEGG; lgi:LOTGIDRAFT_158756; -.
DR CTD; 20237865; -.
DR HOGENOM; CLU_224725_0_0_1; -.
DR OrthoDB; 2964588at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0007219; P:Notch signaling pathway; IEA:InterPro.
DR Gene3D; 2.10.25.140; -; 1.
DR Gene3D; 2.60.40.3510; -; 1.
DR InterPro; IPR001774; DSL.
DR InterPro; IPR011651; Notch_ligand_N.
DR PANTHER; PTHR24041; MUCIN; 1.
DR PANTHER; PTHR24041:SF30; MUCIN-3A; 1.
DR Pfam; PF01414; DSL; 1.
DR Pfam; PF07657; MNNL; 1.
DR SMART; SM00051; DSL; 1.
DR PROSITE; PS51051; DSL; 1.
PE 4: Predicted;
KW Developmental protein {ECO:0000256|RuleBase:RU280815};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00377}; EGF-like domain {ECO:0000256|RuleBase:RU280815};
KW Membrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737, ECO:0000256|RuleBase:RU280815};
KW Signal {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|RuleBase:RU280815, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|RuleBase:RU280815,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..3543
FT /note="Delta-like protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004717210"
FT TRANSMEM 3468..3491
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 168..212
FT /note="DSL"
FT /evidence="ECO:0000259|PROSITE:PS51051"
FT REGION 398..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3292..3314
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 183..195
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
FT DISULFID 203..212
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00377"
SQ SEQUENCE 3543 AA; 405286 MW; E599CAB8610C7698 CRC64;
MEMLVSLVLT IFVTLIHKSN SSGQLEINVL SFRNPAGLNI DGSCCDGVNL VDEQCPTGSC
DHAIEVCVSQ IDGLNEKCKI FVGPPDTNDI TFYDNNQFLY SFDRWQGGVL ISVNITDLDS
GKSDLVDYYN ITLTKDTVAS YLQLPTVENY NFTGSRYLNA TSLQFSVSTY CDSYYYQDCS
VRCIDNDECD GHYTCGSKGA KICNFGWRGT NCDQIIQGSQ KDCSVYDTSI FEISKWISNF
ECYGANDELL LDITEVLQET KEIFGTITIN TTETSVEGHY NPLGLQLSST DFAIGTYLNL
TFFDMSATKK NATHLDGVFR FRSSGDDHRC PLKLDRISGE DDIAPNRCDD KGTCVRYGAA
KSQTYCCCYD GSQGKTCKSS VTTKPSFFTS ITTMKTSTSA TSQASTTETA TSPASSTPIV
TSLESTTLTT PESVTSSTTS ESTQASSGVT SSGVTSSGVT SSGVTSSGVT SSGVTSPVMS
SISTSPNFGE TTDMSSSTDS STTQTLESQS TEEITQPSPS APSSSQTTMS SVSTSSTSEK
AFETSITELG TDSTSTSSQS KITSIETTTN QPVTDAMTES TTTDMLETPE STMQPTTEIP
KPFIPDKSYQ LKLEAAPEEL KDDDRNLEDV ITEAYYEANI DVVEKRLIIA NVTDKRDALG
DDGVLIVEVT YTLVINSTTI NTSTINQPTT AQWTFVLHRN YAISVYLGVD IWYLEYTYSF
YALGRPPVIQ QYNEMELEIF NVWELNSRLV NESYNITILT TEEYVGEMGE EVYRLYYIVT
NINTSSMYHP SNTTAPSAVQ LDASNIFTIY HGISTRYRFS YGVIFYDVID QSELVELSTV
SEKVWDGFTT LNVSVIPIRV ERYMGKEGEY LMKFLYFVKR GSRLISPIQW KGPAPKNFKS
WLEVIDINNR YLRVYTSDVH YRYAHHTGLY IEDRIDRKDW TVMKEQLEKT WSELVIGWNK
NGFSIKIVAT IDYTTNTSEM VQLLTYYIYR KGMIIDASLL DTHFSVTKEL ETRFKVMRTY
GDQYIVITQR TFVELRTQYS FYVGGIISKT DFSYFEQSLI STWNLTKGYT ESDLTVKITY
IDERIDIKTE MTVSKIYYTL QYKLQLVDAY AVKISQNFTI HLESAFNVHT KYQKYMLYKQ
TVTNLITKRY SYSLYFTSKM TRLDFTTLQR RLYSVLKTYL GLSYEFEIIV ANQEEYYTVF
DKESFEMSST RSTVWKINYF IKTSNLWVYP KFVKKIYQSD LKTSLQFEMI NKKTSNIYLE
SRNELISYSY HFSLDFKEPI YYTDWLQIQI SLETAWKKQT GMAVKISIQN VEQLVDVEGN
IYYSMVYFIQ HQQSWIYSLN WQTLDLTILK LDFLNVHGYK YEYFSIKEEW KLSYSFHIGS
DLTVSSTDIT TLKLILRETW CYSLATFISD CSKIEIFPVK QVSETSQSGI KGWDFRYFIK
YEGNVIDVST WPALNIHQFL QYYQSHSFVY KYKFFLNLNY LYRYFQFKIY LNTHVERTDY
DKIKESILSS WLKQNTRFNS TTGLKVIIDS QKEKVDIHGE SSWELGYHIE VNGNTLRPEA
TKPLKPSDLQ IEIHNKTING KYEISSTTSK TSSSLISTSS FAGLIVNSKI EREDKYKFQS
ALEMYFRNIS NIGAESNVTV TIGPMKEVIS ANGHHAWELT YHVAVNGSSV SVEKLKQQID
YSYLQHFLQI KTKYGKTVSV SSSNTTQKKS MLFSVALSHK VTKINLENNI ATQLTKVFKE
LNPEYENCSC LGVKIWNLQE QISATGESTW KVEYQVNVNG RPIDASLVTW PEWKLLNKYL
KHKTSTGYEV NVVDTTNIDY RSTSLFHSLY FNSFIAQSTY TNIKTSLTAS WSKTFEKLGI
VGDLKFKFWR YSEWSSTLKK SVWKLDYEIM LNSTRLDITT VDIDKTSYNL LQQSISNIQS
PSGVKYKLID VSTFKLREYA MHFPLYFTTM VSQSGFVSIK EFIKKTWYDH WKEMNFNQTE
VEIHEQKVMV DMEGKFVYQL VYFLTHNGEV VDSRLYGYQK ILDYISTNLK LINPRGQYYK
VLSKVSHLIR EETLFNIVIH RPLTTSTKVQ FLEFIKSAVS SNMTGQKLSI DVLQQEEVLT
ETSMSVWKVK FYIKSEGEYI VPATVDGLSA MDLYSAYLNT SLNLNFNVLQ FKKDQLYSYK
DRFVLFFKKN VSETHWSILT DALVSFWNNH TEYKDCNCVS IKIKGMQEVV DRNGITRFKL
VYFLYKSNVL VSSQISVDVE FEVLQNVLVK KSTSYEMIKI TETESTRIDS TFSIYLNRGI
RFDHREVTEQ AILDVLITKN ENCCTNVEIL RQMEFLTIKG KSLWQTVFKV TSLNVTVDVK
RLESINATSL QETLHQNLLE YQIEDNTTMI LDLRKSYSLY LTTPVRQTDL IHFQQAVYRY
IRKSVSVNIS VIVPQVTQVV DIEGSLYQKL SAFTTFNGVQ AYPGQGGNLN ITLIQQEINS
MGIKGAKAEY TLIDREITEH DVHYSYSLEQ FIDRPVKHKD LKTFQHVLEL SWTRAIRAEW
KFKIDFDIKI EIVRQEEYLD ISGKSVYKLV YYLHKIRDNM TQGELPSNQL PKLPVDKIHL
QVLIDVLVIG EYKLVKTTEI VQYSSLFTVF LKSPVLLPDI DIIQSNLQQQ WSWYLKKEVS
SVVIVSQEEV VDVSSRSSMW QVSYTVKSSS TIHIDSNYQE ELNETDYRLA LDVNYTDTGN
SYKDLITSRP DSSTKIIRYK ETYSVYFTQR IIETFYSKFE TALISSWKLS RNETVNITIA
GQQEVIAETG MTSFKLLYIV SKSEKQITLY NNELSYNELK NTIVISTAVG TNYKVMEVEE
SFKLEAAFQV YVSQAVYRVD RTLFKEAVKT ELGRLMPDSK WTIAIREPEE YIGANGAVVT
RIPYLVMQNS TVTFPDVTRA PTATSIVAHM STQLKETFSV YDGKKLVKYN SCFTLSVKRE
VGFNIQTNEI EVILTRTWRS VTQEKDVVVS IESTENFVGD FGVKIDQILY TVTLDKIATE
PSFDIKPNDT LVLHEINNVM KYRWSLYKGV NTYRLGVLFS LDVAYSSSLF FTIETKRLIE
ASLEDVWSTN NPTVCENCTV SVVSRKMKIG YNKTIAMDVQ ETVVAQLHYM VQSKGEYLKS
YQTTAPTSEL INTHLNQFEL VVWTEQTFVA RSVYFEGYSW NEKDEIYSAG LHEAWKQDST
TEINITLIDV TRYVDENWNK LTKVQYIVFV NGSDPVQAQL NNTDITAAFN KIGEEKSACS
CKPLKHRKLF VKGSPGSVDH KSVGIAIRAA WMNVNHNSSS LHQLLKVKTK KENSRKKRAV
SESTNQTKYI GDDGDEISPV DYTLSVNDQE PDPVFLNSPT EDDLDAAGVN GCNCSPRKAG
SLRLDGDVED SQFDDVKKAV YEAVVKANPD ISAEDLEVDI LNLSDGIKDS NNNELSEVNY
AINRKDGGDI EDVNYPTSAH LDEALKNHGL ALYEKRAPSD EEDDDWKVIV GAVFGAIAAL
IIVVVATYII VQKRRKQRKM NLKKQERDVS NDIYDEENFS SAVAYSNQVY ETQEAKIDFR
EPE
//
