ID V4B9C8_LOTGI Unreviewed; 2774 AA.
AC V4B9C8;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN ORFNames=LOTGIDRAFT_230254 {ECO:0000313|EMBL:ESP03976.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP03976.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP03976.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
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DR EMBL; KB199905; ESP03976.1; -; Genomic_DNA.
DR RefSeq; XP_009045458.1; XM_009047210.1.
DR STRING; 225164.V4B9C8; -.
DR EnsemblMetazoa; LotgiT230254; LotgiP230254; LotgiG230254.
DR GeneID; 20248248; -.
DR KEGG; lgi:LOTGIDRAFT_230254; -.
DR CTD; 20248248; -.
DR HOGENOM; CLU_000330_1_0_1; -.
DR OMA; WNMDASS; -.
DR OrthoDB; 1221059at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR CDD; cd01460; vWA_midasin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR48103:SF2; MIDASIN; 1.
DR PANTHER; PTHR48103; MIDASIN-RELATED; 1.
DR Pfam; PF00092; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746}.
FT DOMAIN 2561..2762
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 824..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1697..1716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1881..2398
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 533..560
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 1881..1949
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1950..1998
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1999..2043
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2044..2060
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2061..2079
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2085..2119
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2120..2147
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2215..2247
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2252..2290
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2316..2356
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2357..2371
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2372..2398
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2774 AA; 317516 MW; 96070FE0BE430EC0 CRC64;
MVSTLPSSSL YILVHVHNFC NNLENVLTSV LIDMESDVQI TWFWNNLPYI VYFLSVVKNL
KSYPESVFLS RLSLHWNWLY NKLLLPLLSS SSTWRPPSVI LSSINQLQNI MGQENMAAKQ
FVRYLTQYGH PKPYTTQSQS ELQQDMRYCQ DCLNIYKNNK PAVLKLKVEA LVHDGEKLKC
LLQSICESFY NGHSDKENED GIQMKIGKLK CSLIERNILE EEFESMDTRE SADTSGTAAK
PTRLKQYVEL WPIYEHFSLL FEYYLMVNER PELTVHQLRD LITRYTPSTT NHLLDNPDAV
DKKKLYLLLS EVIMNKLWRS SVTKDSTTWL LWNTQLPPPD DTTKIRFRGP GIFHLIPMSY
SIYTLLSTKS PDPKDNSYLP LHVSLGSVDD QLNKLHQLSS YLWKYSGVLS STRLNIGNIE
QGHLMKSFIK MLDSFGVLLT SHSQTKWFEL ISTVEMNYST GTLTTGDILT VQAYYQEVYT
TIEHPALPLV SRCFEVVIDI LQNCTGNGLG LGLAYVGLAS VYLLAPVGPV DPVEKNAIKM
KNFENQIKEI ECEIEVYESN IRLKTGLSIE DIKTSKLHPR LQYLIERKQH LQHKILLLTD
QQAYRPDPLQ YLSLVQDVKA YLESIGSIER VTALLSKLQT ANQIEGGPHV DEVIITSCLR
EEEAWQQTQQ SFLDSLDKHY WCYPDLIIPF KALIQQMRLG VSILTQTVET SHKQFTLSKQ
IYGQSLEEVM LILSQFPNIS QNHETFHDLT KILIYDTTCE LVNTSISTQN TDSDHIHDVL
SKLLLCGLYL IKIHCINSGE LTSHITQTLS NLFTTFVTAW QDQETRRREK EAEDASLYRY
RSKNHGDEKT DEDKDEAEFK SSFPSFENVY ADLVGPQSLE EVGNLTEEDE SIKSTPYSIS
IEDMYTVYQI HDLLFTSLIT TDWLPSVSYT KPTIHDYIQP AIIAYNIASQ VATKSPEALG
RDVDTGVVGG HLLISGVVQQ TILSGLNNTQ SQTENSLCLK PTEYYDIYYD SNVNEVSQCK
VILDRFLVRL DELLIEYPQH PTLSQIVAII RRILSFSITC PIMKFLVGLE LLLEKTKDWE
ANAAKHVSVM THFKEVSAMV VQWRKLELGC WKNTMLIEER KCEKSVSKWW FHLYQLITSY
LHNATNTQET VESEKLVTSL KEFLEKSNLG EFKYRLKMIL AFHCQVYKMD ASDKQVEVLN
LLWNLYQFYL QYLPNIEAEI TSQKTPLLKQ LKGFVKIARW SDLNYWALKQ STEKTHRTVH
KYSKKYQMVL NQPITKLLGE KGDNLSMMTS GSGALSKGGV LCDRLEVYRQ TVYTQKLRHD
KSEVDDKTLS SLQQRLPILI PKLCKHWKTV VKSLPYTQTL KGLDEFTGDV IETVHELQQA
EVSTGDDKEK QKSAAKFLNL RKRKSLAELF KYLTKMGLSY RKGLILDDLT KQDNSLSLQP
LDITVAKSHY QLSEVLASQW ENCQNYFYRC ITRKAQLEQA VIQPAQDLGL GNVERCRGFS
HHLHHLFTQQ RHELGETFTS FLQIRKFTNE IKRLKKEDGF SLPSQFQVQY WLGRVKNLCI
QLLEGLNQYN ILLQSCPTPS TSTSILPDIT QLSPLSNIKY GDTMWLQTSE KIQSIISRTE
TEYKKLMKLS QKHFLLWEDV KLIEGTSQKV KNFSDTLTEI TVLFTDPIDN TDCALNTPLN
ILIGSITNCI GEVEEWAGQS RDRTDSEAES SDMMDNGEES GVMIDSLIET VLLVVQKLLS
KHPVVEKKTE EEEEEEELED GYIVKGLLEN LKFDITEIKT KQISTMIMSI IEKTMLYFEN
EDTVSNGETS MKLLLRCLPL LERYCDITEY FLAHVICSHR CCGKLLSVLL ALFTELAMKG
FCVPPELSDE MEQEGATEFK DIEQGGLGEG EGVKDVSDQI ETEDQLDDTR RAGEEKKEDN
DHQDIPAEDN AIEMSEDFEG KPQDMNQEEE EDKDKNDDDN DDDDELDKEM GDIEDQETDK
LDEQLWGSDE EEDNESDEKP KEETGPGDGE KEESELVAKD DNLDKSQDKD DKQNDKQQGE
EEEQKDEINE MDDIEEEGYN DDKIDANQGD SKEPEAQPET MDLPEDLNLD AEEAGEKEEE
TEMDDPAEGK EDGNEDEEGT EDVDKLKDKE EKEEEGKDEN QESEKNDANE DGAEEEEKKE
ENGGEENKDN DNEEREDDEG QGDAGFTADD EKIEEEEDKG IEEEKNDKMD TQGQTQHDDT
NIENSDTAQD QASQADNEQQ EKVGSGMADT QQDDGHEGEQ SSEVTQGSNE KKKEMKRQPG
KSREDRSLGS PDQSYQRLKT TEETHPEDEE EESGQEKKEG ELYEHIKDSK SHHDAQTLDV
ANDDTEEQMI PNKDQEEVKD DDDEPMEDVK PLDDEVDNKE QEEEIEKKEA NKVKGKKLAN
DKMEDMKIDQ DEEMEEREKV EISGERILTM TANRGPTSTI HTAVEHLHMD NGPSEIDVEK
IRADLEENVN LWSHQSLTTP EQMVEASSAW QRYEAITSGL SQELCEQLRL ILEPSQATQL
KGDYRTGKRL NMRKVIPYIA SQFRKDKIWL RRSKPSKRQY QIMLAIDDSS SMLDNHSKQL
AFESLALISN ALTLLEAGDL AVTSFGESVK VLHSFTDQFS SQSGANILHQ FTFEQKKTKI
AQLLQQATSL MIDGRSRQHG IVGNPETSQL LLIVSDGRGL FSEGMEAVKS AVRKAREANI
FLVFVIIDNP ENKDSILDIR VPIFKGPGKL PEIKSYMEQF PFPFYIILRD INSLPITLSD
ALRQWFELVT AADR
//
