ID V4BB30_LOTGI Unreviewed; 950 AA.
AC V4BB30;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 08-NOV-2023, entry version 43.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
DE Flags: Fragment;
GN ORFNames=LOTGIDRAFT_137764 {ECO:0000313|EMBL:ESP03217.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP03217.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP03217.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) +
CC hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00034408};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR EMBL; KB200084; ESP03217.1; -; Genomic_DNA.
DR RefSeq; XP_009046140.1; XM_009047892.1.
DR AlphaFoldDB; V4BB30; -.
DR EnsemblMetazoa; LotgiT137764; LotgiP137764; LotgiG137764.
DR GeneID; 20233947; -.
DR KEGG; lgi:LOTGIDRAFT_137764; -.
DR CTD; 20233947; -.
DR HOGENOM; CLU_002289_1_0_1; -.
DR OMA; KHEHKRH; -.
DR OrthoDB; 1013180at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR001717; Anion_exchange.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF47; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR00165; ANIONEXCHNGR.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Anion exchange {ECO:0000256|ARBA:ARBA00022681};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 427..448
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 481..500
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 512..534
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 570..589
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 619..640
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 652..672
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 711..738
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 759..782
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 810..829
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 836..855
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 887..916
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 81..349
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 399..888
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 365..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 370..385
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:ESP03217.1"
SQ SEQUENCE 950 AA; 107731 MW; 8004434D1B8CCF59 CRC64;
FTGHRWEDVR GIRRHKIARR NKSQLHSIVH IGKAHKEKKK PKQKFDHSPH DVFVELDELF
VKDEHEWEWR EKARWIKFEE DVEEGADRWG KPHVASLSFH SLIELRKGLE TGTVLLDLES
EDFPNIVHNV VENLLIRDLI DEDVKGKILR TLLLKHKHQN EKLGLLRSIS TSSFNGGLGS
SSGGLHRSKE DEKKFFKNEK VNLEMVKVDM DNNTTDSSNI HIGLTPQDPK KNVQEIMKRI
PVGSEASTVL VGTVDFLSKP VMAFVRLSEG RQLENVTEVP LPVRFVFILL GPEKGGMDYH
EVGRSLSTLM TNQFFHDVAY RAESREALLQ AINGFLDDTI VLPPGDWDQK TLLPIMDMAR
KRANLRRRKK QKQEEHQELL EKEKKDKVPL DPLQRTGCLF GGLINDIKRR YPHYISDFKD
ALNGTCLASF IFIFFACLSP CIAFGGLLSE KTKGLMGVSE TVLSTSLCGI VMGLFSGQPL
LIVGATGPVL VFEQSLYKFC ESNGIEFLSF RLWIGFWVFV ISVLTVAAEG SFLIRYVTRF
TEEIFAILIS LIFIYEVLKK LNKVSQLYLS GYLGFSGLLG SLVITGYNIS DPFDMYYNVN
GSDAIHGDTE KVKNKPNTAL MSTILCIGTF LVAWFLKICR NSKFLGRSVR RALGDFGILL
AILSMAVLDY LVRDDVYTQK LKIGSPFVPT LPHKRGWLIN PMSPKVMQKV WIIPAAIIPA
FLIFILLFME IQLTEVILNK KDRKLKKGSG FHLDQFLMGF LTFVCGCLGL PWMCAATVRT
IAHVSSLSVM SRTHAPGEKP KLVEVKEQRL TNVMVSLMIG VSLTLGVVLK NIPTMVLFGV
FLYLGIVSLG SVQMFKRIKL LLMPVKYHPS VGYVRRVQTF KMNLFTIIQI FSLVILWIVK
STAAAIAFPF FLILLIPVRN KIMPKLFTHK EFEEVRHMIS PFDMLAAFDC
//