ID V4BH53_LOTGI Unreviewed; 843 AA.
AC V4BH53;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 34.
DE RecName: Full=MMS19 nucleotide excision repair protein {ECO:0000256|RuleBase:RU367072};
GN ORFNames=LOTGIDRAFT_234861 {ECO:0000313|EMBL:ESO87854.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO87854.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO87854.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- FUNCTION: Key component of the cytosolic iron-sulfur protein assembly
CC (CIA) complex, a multiprotein complex that mediates the incorporation
CC of iron-sulfur cluster into apoproteins specifically involved in DNA
CC metabolism and genomic integrity. In the CIA complex, MMS19 acts as an
CC adapter between early-acting CIA components and a subset of cellular
CC target iron-sulfur proteins. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBUNIT: Component of the CIA complex. {ECO:0000256|RuleBase:RU367072}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton, spindle
CC {ECO:0000256|RuleBase:RU367072}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123, ECO:0000256|RuleBase:RU367072}.
CC -!- SIMILARITY: Belongs to the MET18/MMS19 family.
CC {ECO:0000256|ARBA:ARBA00009340, ECO:0000256|RuleBase:RU367072}.
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DR EMBL; KB202823; ESO87854.1; -; Genomic_DNA.
DR RefSeq; XP_009061458.1; XM_009063210.1.
DR AlphaFoldDB; V4BH53; -.
DR STRING; 225164.V4BH53; -.
DR EnsemblMetazoa; LotgiT234861; LotgiP234861; LotgiG234861.
DR GeneID; 20249660; -.
DR KEGG; lgi:LOTGIDRAFT_234861; -.
DR CTD; 20249660; -.
DR HOGENOM; CLU_005943_2_0_1; -.
DR OMA; FSFMPEF; -.
DR OrthoDB; 38995at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0097361; C:CIA complex; IEA:UniProtKB-UniRule.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-UniRule.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005819; C:spindle; IEA:UniProtKB-SubCell.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-UniRule.
DR GO; GO:0016226; P:iron-sulfur cluster assembly; IEA:UniProtKB-UniRule.
DR GO; GO:0097428; P:protein maturation by iron-sulfur cluster transfer; IEA:UniProtKB-UniRule.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 2.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039920; MET18/MMS19.
DR InterPro; IPR024687; MMS19_C.
DR InterPro; IPR029240; MMS19_N.
DR PANTHER; PTHR12891; DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19; 1.
DR PANTHER; PTHR12891:SF0; MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG; 1.
DR Pfam; PF12460; MMS19_C; 1.
DR Pfam; PF14500; MMS19_N; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|RuleBase:RU367072};
KW Cytoskeleton {ECO:0000256|RuleBase:RU367072};
KW DNA damage {ECO:0000256|RuleBase:RU367072};
KW DNA repair {ECO:0000256|RuleBase:RU367072};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|RuleBase:RU367072};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 1..141
FT /note="MMS19 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14500"
FT DOMAIN 383..792
FT /note="MMS19 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF12460"
SQ SEQUENCE 843 AA; 94843 MW; 4722E93A5DDF5AA8 CRC64;
MKSDFVHGYI QTMDAEKDPR NLILAFQIAR KIIDNFSLGV FVEEMFEVVS CYFPVSFSPP
PDNPHGITKQ DLVLSLRSCL SATPLFSEYC LPLLLEKLTS DITSAQIDSL QTLAECAPVY
GTAALKEYIS SFYSCLRKEV VDGDSEEVKR ESLKCLSCLI STLSTDITDI SSSSVLKSFI
EEIFSEYRIY ILKSDVKILY NASSLLHCIC DANSIACCMV LETAVPLVLL QYNNQTQINC
RRCLIDILNM FISCAARHNT EQVLKIILIH KADLISTYTE LLLARDKDIS CYGIRGVAAI
LKCNNVLSES EAELFSKHIA TILLSNSDKK IRNECVITVQ LLASQFPVIV KSEIQTKLIE
KLNQDQMEID GDSSVSKEDL MGIITSISHH KLLLTDITYF IFLQLNQQKD KICSSEVLTS
CLCSMVENNK TNGDVLDYTN TSIVPNILQL IVDQYQSLTS NDIEHLATIL RISCTNSSSS
ICEGLYKQIV DLFLHGKLKG ITLKDFQPLQ NRSNKSQLCS LPLVTAVVCS VPLSETMVNI
DDIVSSVMSI CTTTDDLTIC EYGSKCIAGL LNKLTESYIE GILMDIDKLW DGLFTVNQSS
ENVERSVILL TWITKALVLR NHCKAKEYIQ KLLELLSVDI VGSIVAEYFY IIVTQYKDIL
NSEMRADIKM FYHQRLFLEN KDRLVTDYQE SESGAIKKNY LIVLSNLMKP LQKQVLLPEL
PLLLPLLIHS LVYEDRNLIQ VTLTTIQSLC ENKEGSLLLC KHLDSVIPQL LQLSKYLSDM
KIRISALKCL NTVSHLPSHL ILPYRNTVIK SLVQVLDDKK RLVRNEAVTA RSKWFLIAEP
GSS
//
