ID V4BHL2_LOTGI Unreviewed; 752 AA.
AC V4BHL2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 32.
DE RecName: Full=CUB domain-containing protein {ECO:0000259|PROSITE:PS01180};
GN ORFNames=LOTGIDRAFT_227965 {ECO:0000313|EMBL:ESP05332.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESP05332.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESP05332.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00059}.
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DR EMBL; KB199650; ESP05332.1; -; Genomic_DNA.
DR RefSeq; XP_009043877.1; XM_009045629.1.
DR AlphaFoldDB; V4BHL2; -.
DR EnsemblMetazoa; LotgiT227965; LotgiP227965; LotgiG227965.
DR GeneID; 20247486; -.
DR KEGG; lgi:LOTGIDRAFT_227965; -.
DR CTD; 20247486; -.
DR HOGENOM; CLU_370189_0_0_1; -.
DR OrthoDB; 5406662at2759; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR CDD; cd00041; CUB; 3.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 3.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR46908:SF4; CUBILIN HOMOLOG; 1.
DR PANTHER; PTHR46908; CUBILIN-LIKE PROTEIN; 1.
DR Pfam; PF00431; CUB; 3.
DR SMART; SM00042; CUB; 3.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 3.
DR PROSITE; PS01180; CUB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00059}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 552..576
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 137..250
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 264..375
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 380..495
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT REGION 586..605
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 620..648
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..687
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 688..752
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 264..291
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00059"
SQ SEQUENCE 752 AA; 83808 MW; E4449EAD08FC63FD CRC64;
MNKQNVLVVS AERRRSTVKP RPHFQLSVKN RSTSKLKPLF PTSTAETVSN KTNTQFPYQR
QKQSHFSKLA DSPITSSVPS RRYGYPQLIE STQIIDTIVV KGSIAKNDNS MTTVATSSAT
YFKDMATLLT ESVTNDCVHD LTKPSGDIIF PNPFLMYKSN LDNFTLSVCR WRIRVPMGPN
VKIRFNSLSL NLEKEYLQLS VGMGGATKMR RITGTKIPRD IIFNGTEIWL TLKYDHVNSN
AQIAIMFTET SEEATFPRQE NSTCGGEVKK LQGNLISPGY PFSNYSNSEV CSWTINAPAN
SVIKIVIKSL YTEIYDQVTI GIGLLPDVQS SKVLTLFGHL EEEKETIIPS NSMWINFQSD
DSVSAKGFLI YFEVILQEIC RFNNEVFTSE HGTITSVNYP NPYPINSECS WRILAPPMSK
IQLIVHDFLV QDDRDFLLVG KGEDVFEGPF ETYSGNLTKA LNVTLDSDKV WLHFTSKQLE
EETVYSGFNL SYTVILPDIF GSLVIEQGVV TEPPIITTFV SQDQPLSDDL SELSKDQNGG
RAGSESSNLP EWLIGVIVVV ILLIIVFFAM VIYSLVKERK KSRAGSYGAA TSVSSPEEPK
DVNKTDGCIR ITSFITDSET NKENTNGWVD TEAATLQRRP QGRSNPVFND NEELKKKGDK
KKSEKSNDKK HKELKEKNTD KDSNASAADR TEAASNNVTK PDDDTKINVS AEVNTIGQPE
DTSLTLTDEQ VLTVMENSSE NTGGNKDLST NL
//
