ID V4BYX3_LOTGI Unreviewed; 626 AA.
AC V4BYX3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 22-FEB-2023, entry version 29.
DE RecName: Full=EGF-like domain-containing protein {ECO:0000259|PROSITE:PS50026};
GN ORFNames=LOTGIDRAFT_189647 {ECO:0000313|EMBL:ESO94324.1};
OS Lottia gigantea (Giant owl limpet).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Mollusca; Gastropoda;
OC Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO94324.1, ECO:0000313|Proteomes:UP000030746};
RN [1] {ECO:0000313|EMBL:ESO94324.1, ECO:0000313|Proteomes:UP000030746}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23254933; DOI=10.1038/nature11696;
RA Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H., Aerts A.,
RA Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V., Lindberg D.R.,
RA Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT "Insights into bilaterian evolution from three spiralian genomes.";
RL Nature 493:526-531(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KB201847; ESO94324.1; -; Genomic_DNA.
DR RefSeq; XP_009055164.1; XM_009056916.1.
DR AlphaFoldDB; V4BYX3; -.
DR EnsemblMetazoa; LotgiT189647; LotgiP189647; LotgiG189647.
DR GeneID; 20244852; -.
DR KEGG; lgi:LOTGIDRAFT_189647; -.
DR CTD; 20244852; -.
DR HOGENOM; CLU_436999_0_0_1; -.
DR Proteomes; UP000030746; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR Pfam; PF00008; EGF; 1.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS50026; EGF_3; 1.
DR PROSITE; PS51257; PROKAR_LIPOPROTEIN; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..626
FT /note="EGF-like domain-containing protein"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004718424"
FT TRANSMEM 372..397
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 302..341
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 89..241
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 477..516
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 585..626
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 99..208
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..241
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..516
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 610..626
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 331..340
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 626 AA; 68345 MW; C20B96C24AA09CB0 CRC64;
MTSKVCVSVC LVLGCVFAIY GKVSPIDLDL NLDGKESKDI GFDGLTSLAS FSTVSDPKLD
ENSTNAKNAV LPGDIREFSL TQWTAKQEIQ PKNGTSFTRV KRASKKGKKK RGKGRKRKGR
KGMKKKKGKK RKGKKKGQKG KTIKKGKKKG KRKKKKGRKG KKGKNVKKLK GKRKGKKRNG
KKKGKKGNGK KKGKKGNGKK KGKKGNCMKN CKKVYDKKKD KGKKIIKSKK EPEGKKESDD
NLKELLEKIK EEKDDAVNSP ELKKIYPVKV KIETTMPVNK EKMKEIKELS SIKKKTDKTL
TKIDPCELKP CRHNGICEKL GSTIKDYKCV CPAGRKGKHC EFSAEKIKLK SDQGKPKKHK
KHKAKQEDDA NLALIISLST VIPVTVVIAL ILTIHCVRVK NKRAQLLAKF RRDKRFGKVP
EPVPGVMALS NQMFCGCCSK QKKKAPAYTI KDIEVELEKQ ATIEKLNELI DKASGTKASK
LGGGKAKKGI KGGKSDASMM SEGSEGSETA GSSWGSDVSG VYGSEVSGIS GSAVSAVSAV
SAVAAPVSEA KASDEQIEQL ADKVAEAKLS VEQVDQLTEL VQKVSKAKME QEAQLTELDQ
QVSTAPMEEE QHPPAPPSPP PLPPLP
//