GenomeNet

Database: UniProt
Entry: V4BZG2_LOTGI
LinkDB: V4BZG2_LOTGI
Original site: V4BZG2_LOTGI 
ID   V4BZG2_LOTGI            Unreviewed;      1616 AA.
AC   V4BZG2;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=LOTGIDRAFT_118343 {ECO:0000313|EMBL:ESO94539.1};
OS   Lottia gigantea (Giant owl limpet).
OC   Eukaryota; Metazoa; Lophotrochozoa; Mollusca; Gastropoda;
OC   Patellogastropoda; Lottioidea; Lottiidae; Lottia.
OX   NCBI_TaxID=225164 {ECO:0000313|EMBL:ESO94539.1, ECO:0000313|Proteomes:UP000030746};
RN   [1] {ECO:0000313|EMBL:ESO94539.1, ECO:0000313|Proteomes:UP000030746}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23254933; DOI=10.1038/nature11696;
RA   Simakov O., Marletaz F., Cho S.J., Edsinger-Gonzales E., Havlak P.,
RA   Hellsten U., Kuo D.H., Larsson T., Lv J., Arendt D., Savage R.,
RA   Osoegawa K., de Jong P., Grimwood J., Chapman J.A., Shapiro H.,
RA   Aerts A., Otillar R.P., Terry A.Y., Boore J.L., Grigoriev I.V.,
RA   Lindberg D.R., Seaver E.C., Weisblat D.A., Putnam N.H., Rokhsar D.S.;
RT   "Insights into bilaterian evolution from three spiralian genomes.";
RL   Nature 493:526-531(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KB201802; ESO94539.1; -; Genomic_DNA.
DR   RefSeq; XP_009054818.1; XM_009056570.1.
DR   EnsemblMetazoa; LotgiT118343; LotgiP118343; LotgiG118343.
DR   GeneID; 20231607; -.
DR   KEGG; lgi:LOTGIDRAFT_118343; -.
DR   CTD; 20231607; -.
DR   KO; K21862; -.
DR   OMA; QIWVNDT; -.
DR   OrthoDB; EOG091G01WJ; -.
DR   Proteomes; UP000030746; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000030746};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030746};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     56     74       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     86    106       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    118    137       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    179    199       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    315    341       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    418    436       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    448    473       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    479    503       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    523    551       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    571    590       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    611    637       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    793    812       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    824    843       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    863    889       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    909    935       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1028   1052       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1116   1134       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1146   1168       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1180   1209       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1230   1256       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1334   1358       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       54    347       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      415    637       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      791   1061       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1114   1372       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1377   1419       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   1616 AA;  185340 MW;  01F81A77F891AF7A CRC64;
     MILCDIFFLF LQTFVVIAKR FKKKFIYRFS STSAFFLLPP WNPLRQLAVR IATNQFFDYF
     VILTIIVNCV FMTMPDLQIT ETLEYIFLAI YVVEMLIKVT ARGFIIDKYT YLRDGWNWLD
     FIVIVLAFVT ILIQLIYPDL SIGNLQVLRT FRVLRALKTV SIVPGLKTIV NALLRAFKML
     IDVIMLTFFC LMVFALFGLQ VYQGVLRHKC VSDLPFDPNT TTPETYDTLY ANHIRNISNW
     YGEPNDYMLC GNTSGAGGCP ENFTCLPDIG DNPNYGYTNY DNFGWAILNA FQLITLDFWE
     DNYDKVIRAS GPWNVVFFIL VVFFGSFYLI NLMLAVVALS YEEEAENAGK VNTMYTNEKE
     AFLKHQDSRQ SLHDAMSYDG QLVDRNCNIC SSCCRCFVPW IKFQNIIHRF ITDPLLDLFI
     TLCILMNTII MACESHEMSE TTQETIRISN YVFTSVFTLE AILKIIALSK YYFASGWNIF
     DFVIVLASLI DLGLEDIDGL SVFRTFRLLR VFRLAQSWST MRILISIIVN TFGALGNLTV
     VLFIIIYIFA VTGLQLFNRS YTADKFSPDG IPRWNFSSFF HAAMMIFRVL CGEWIEPLYD
     CMRAEDELCM LVFLPALVLG NFMVLNLFLA LLLNAFATDS LNKHKESNKD DTSRFKLAFH
     RIKHLCCCCL PGNSNVVKPD ERGEEDVIGQ FETSEKRDKF ADFGKALDGM KKEVDLEKGE
     KKDDGDKDVD GLELGDTAED HKEGEEPPEL RDCLPLCCTK GISCSKSFDP STPFGKFWKR
     MREACSKIVD NKIFEYGILF VIFASSVTLA FEDVHLEENQ ELKLALYYLN IIFCVIFVAE
     MLFKWFAYGL WKYFTNFWTL LDFLIVCISV ASLIAESLGI SNLTAFRSLR TLRALRPLRA
     ISRLQSMRIV VNALMRAIPA IFNVFIVCMV FWLIFSIMGV QFFAGKFYKC VDGNGEILLN
     TVVPNKTECL RNSNYKWKNS NVNFDNVLQG YLALFQVATF EGWMEVMRDA IDSTEVDVQP
     KFENNIYYYL YFVAFIIFGS FFTLNLIIGV IIDNFNVLKK KYDGSYLDMF LTPNQRNYYN
     TLKKLGNKKP QKTIKRPKTK FQGFFFDIAT SNKFELSIIV IIFLNMITLA IESYKQSDTI
     RDALKILNII FTVIFILECM IKLIGMRWHY FRQFWNVFDF IIVLLSVTGL ILDDLLAGVF
     VTPTLLRVGR VFRIGRVLRL IKAAKGLRKL LFALIISLPA IVNIGALLAL IMYIYAILGM
     SSFKNLRVSP MMNNDIVNFQ TFANSIILLF RLSTSAGWNE ILDPLLIEYP DCDPDTIELS
     NGQRIKQTYG ECGIPWLAIP YMVTYIFIAY LVIINMYIAV ILENFNQAHE QEEVGITEDD
     FDMFYVVWER YDPLATQFIK YDVLSDFLAD LEEPLGIPKP NEITIVAFNL PIVEGDKLHC
     LDILMALVKK HLGSVDETEE SKALHKKMET KFGDIFPSRV MTVKKSTTMQ RKKEDVAART
     LQRCWRSFKT QKALKNITSL AMQQKTDIAN QASQSRANSI ISLGRRLSNA LNTFFHSSRP
     SSALSRVSLK SNTSHHSLQP ISKKSNITNT LKVPSINTLY SSGTTSPPGD TQDLYL
//
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