ID V4JZA3_EUTSA Unreviewed; 434 AA.
AC V4JZA3;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE RecName: Full=3-beta hydroxysteroid dehydrogenase/isomerase domain-containing protein {ECO:0000259|Pfam:PF01073};
GN ORFNames=EUTSA_v10011495mg {ECO:0000313|EMBL:ESQ30875.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ30875.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ30875.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
CC -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC {ECO:0000256|ARBA:ARBA00009219}.
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DR EMBL; KI517809; ESQ30875.1; -; Genomic_DNA.
DR RefSeq; XP_006393589.1; XM_006393527.1.
DR AlphaFoldDB; V4JZA3; -.
DR STRING; 72664.V4JZA3; -.
DR EnsemblPlants; ESQ30875; ESQ30875; EUTSA_v10011495mg.
DR GeneID; 18010716; -.
DR Gramene; ESQ30875; ESQ30875; EUTSA_v10011495mg.
DR KEGG; eus:EUTSA_v10011495mg; -.
DR eggNOG; KOG1430; Eukaryota.
DR OMA; STAHWFD; -.
DR OrthoDB; 1133at2759; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR GO; GO:0047012; F:sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating) activity; IEA:EnsemblPlants.
DR GO; GO:0060918; P:auxin transport; IEA:EnsemblPlants.
DR GO; GO:0099402; P:plant organ development; IEA:EnsemblPlants.
DR GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR CDD; cd09813; 3b-HSD-NSDHL-like_SDR_e; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR Pfam; PF01073; 3Beta_HSD; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 403..421
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 13..288
FT /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT /evidence="ECO:0000259|Pfam:PF01073"
SQ SEQUENCE 434 AA; 47631 MW; D67D9257F0B068C7 CRC64;
MVTEVTETER WCVVTGGRGF AARHLVEMLV HYQMFNVRIA DLAPAIQLEP HEETGILGEA
MRSGRVDYVS ADLRNKSQVV KAFQGAEVVF HMAAPDSSIN NYQLHYSVNV QGTTNVIDAC
VEVGVKRLIY TSSPSVVFDG VHGILNADET MPYPSKHNDS YSATKAEGEA LIMKANGRNG
LLTCCIRPSS IFGPGDKLLV PSLVAAARAG KSKFIIGDGS NLYDFTYVEN VVHAHVCAER
ALASGGEVCA KAAGQAYFIT NMEPIKFWEF MSQLLEGLGY ERPSIKIPAI IMMPIAHIVE
LAYKLLGPYG MKVPQLTPSR VRLLSCSRTF DSSKAKDLLG YAPVVPLQEG IKRTIDSFSH
LTAQNQPKEE VTNKLRWKKQ TLIAIVILIT LYLKFVATTG YSVVITAILV ASIILFFRGI
IPEKMKLVGS EKND
//
