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Database: UniProt
Entry: V4KX25_EUTSA
LinkDB: V4KX25_EUTSA
Original site: V4KX25_EUTSA 
ID   V4KX25_EUTSA            Unreviewed;       599 AA.
AC   V4KX25;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 39.
DE   RecName: Full=Serine hydroxymethyltransferase {ECO:0000256|RuleBase:RU000585};
DE            EC=2.1.2.1 {ECO:0000256|RuleBase:RU000585};
GN   ORFNames=EUTSA_v10007136mg {ECO:0000313|EMBL:ESQ34592.1};
OS   Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX   NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ34592.1, ECO:0000313|Proteomes:UP000030689};
RN   [1] {ECO:0000313|EMBL:ESQ34592.1, ECO:0000313|Proteomes:UP000030689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA   Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA   Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA   Mitchell-Olds T., Schumaker K.S., Wang X.;
RT   "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL   Front. Plant Sci. 4:46-46(2013).
CC   -!- FUNCTION: Interconversion of serine and glycine.
CC       {ECO:0000256|RuleBase:RU000585}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=(6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O =
CC         (6S)-5,6,7,8-tetrahydrofolate + L-serine; Xref=Rhea:RHEA:15481,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15636, ChEBI:CHEBI:33384,
CC         ChEBI:CHEBI:57305, ChEBI:CHEBI:57453; EC=2.1.2.1;
CC         Evidence={ECO:0000256|RuleBase:RU000585};
CC   -!- COFACTOR:
CC       Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC         Evidence={ECO:0000256|ARBA:ARBA00001933,
CC         ECO:0000256|RuleBase:RU000585};
CC   -!- PATHWAY: One-carbon metabolism; tetrahydrofolate interconversion.
CC       {ECO:0000256|ARBA:ARBA00004777, ECO:0000256|RuleBase:RU000585}.
CC   -!- SIMILARITY: Belongs to the SHMT family. {ECO:0000256|ARBA:ARBA00006376,
CC       ECO:0000256|RuleBase:RU000585}.
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DR   EMBL; KI517683; ESQ34592.1; -; Genomic_DNA.
DR   RefSeq; XP_006416239.1; XM_006416176.1.
DR   AlphaFoldDB; V4KX25; -.
DR   STRING; 72664.V4KX25; -.
DR   EnsemblPlants; ESQ34592; ESQ34592; EUTSA_v10007136mg.
DR   Gramene; ESQ34592; ESQ34592; EUTSA_v10007136mg.
DR   KEGG; eus:EUTSA_v10007136mg; -.
DR   eggNOG; KOG2467; Eukaryota.
DR   OMA; SIQREHG; -.
DR   OrthoDB; 5358603at2759; -.
DR   UniPathway; UPA00193; -.
DR   Proteomes; UP000030689; Unassembled WGS sequence.
DR   GO; GO:0004372; F:glycine hydroxymethyltransferase activity; IEA:UniProtKB-EC.
DR   GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR   GO; GO:0019264; P:glycine biosynthetic process from serine; IEA:InterPro.
DR   GO; GO:0035999; P:tetrahydrofolate interconversion; IEA:UniProtKB-UniPathway.
DR   CDD; cd00378; SHMT; 1.
DR   Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR   Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR   HAMAP; MF_00051; SHMT; 1.
DR   InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR   InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR   InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR   InterPro; IPR001085; Ser_HO-MeTrfase.
DR   InterPro; IPR019798; Ser_HO-MeTrfase_PLP_BS.
DR   InterPro; IPR039429; SHMT-like_dom.
DR   PANTHER; PTHR11680; SERINE HYDROXYMETHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11680:SF60; SERINE HYDROXYMETHYLTRANSFERASE 6; 1.
DR   Pfam; PF00464; SHMT; 1.
DR   SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR   PROSITE; PS00096; SHMT; 1.
PE   3: Inferred from homology;
KW   One-carbon metabolism {ECO:0000256|ARBA:ARBA00022563,
KW   ECO:0000256|RuleBase:RU000585};
KW   Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW   ECO:0000256|RuleBase:RU000585};
KW   Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU000585}.
FT   DOMAIN          142..546
FT                   /note="Serine hydroxymethyltransferase-like"
FT                   /evidence="ECO:0000259|Pfam:PF00464"
FT   REGION          1..88
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          104..125
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        60..74
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   599 AA;  66528 MW;  591365DDA807343D CRC64;
     MDRAQSDLSL GFGSSHALPL PPPRIPIADD SITLQIDSSF RPSSNPMPPV PLQLLEQRFD
     DAGSRSRVFE EPDDVDNHND DDDDGDDQRE EEQFILLGHP MKLKRSRGSN SMSSPSPCKR
     FAADSGVEGR RAAVKAWGDQ SLEEADPEIH EFMEKEKQRQ FRGIELIASE NFVCRAVMEA
     LGSHLTNKYS EGMPGARYYT GNQYIDQIEI LCQERALAAF GLHHEKWGVN VQPYSCTSAN
     FAVFTGLLMP GDRIMGLDSP SGGHMSHGYY TPGGKKVSGA SIFFESFPYK VDPRTGYIDY
     DKLEEKALDY RPKILICGGS SYPRDWEFPR FRHVADKCGA VLMFDMAQIS GLVAAKECPN
     PFDYCDIVTS TTHKSLRGPR GGIIFYRRGL KSKKQSINLN HCESNIQYDF EEKINFSVFP
     SLQGGPHNNH IAALAIALKQ AASPEYKVYM RQVKKNAKAL ASALISKNCK LVTGGTDNHL
     LLWDLTPFGL TGKVYEKVCE MCHITVNKVA IFSDNGVISP GGVRIGSPAM TSRGCLESDF
     ETMADFLYRA AQIASAAQKE HGKLQKEPLK SIYHCKDIAD LRNQVEAFAS QFAMPAFDI
//
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