ID V4L3N2_EUTSA Unreviewed; 1326 AA.
AC V4L3N2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN ORFNames=EUTSA_v10006573mg {ECO:0000313|EMBL:ESQ34363.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ34363.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ34363.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
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DR EMBL; KI517683; ESQ34363.1; -; Genomic_DNA.
DR RefSeq; XP_006416010.1; XM_006415947.1.
DR EnsemblPlants; ESQ34363; ESQ34363; EUTSA_v10006573mg.
DR Gramene; ESQ34363; ESQ34363; EUTSA_v10006573mg.
DR KEGG; eus:EUTSA_v10006573mg; -.
DR eggNOG; ENOG502QQJE; Eukaryota.
DR OMA; FEVHAKR; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0006952; P:defense response; IEA:UniProtKB-KW.
DR GO; GO:0051707; P:response to other organism; IEA:UniProt.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 4.
DR Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR042197; Apaf_helical.
DR InterPro; IPR044974; Disease_R_plants.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000157; TIR_dom.
DR InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR11017:SF595; DISEASE RESISTANCE PROTEIN (TIR-NBS-LRR CLASS)-RELATED; 1.
DR PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR Pfam; PF00560; LRR_1; 2.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF01582; TIR; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM00369; LRR_TYP; 7.
DR SMART; SM00255; TIR; 1.
DR SUPFAM; SSF52058; L domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51450; LRR; 1.
DR PROSITE; PS50104; TIR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Plant defense {ECO:0000256|ARBA:ARBA00022821};
KW Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 12..156
FT /note="TIR"
FT /evidence="ECO:0000259|PROSITE:PS50104"
SQ SEQUENCE 1326 AA; 149082 MW; 4ACCA43857443148 CRC64;
MEAAVLSKPH RLKYDVFLSF RGEDTRDNFV GLLYDELKKQ IRVFRDNEGM DRGNEIAPSL
VAAMEDSAAS VVVLSPRYAD SRWCLDELAM LCDLRRSSLK RPILPIFYKV DPSHVRKQSH
HFAEDFEEHA KRFTKEEGSG EDEMIKLVVK KVLEEVSNTP EKVGEYTVGL ESRVHDLMDL
VDVKASSGVQ ILGLYGMGGI GKTTLAKSFY NKILENFEEH RVFISNVRES SSDQDGLVNL
QKTLIKALSP VPPQIENVNG GLDKIRKSVH EKKILAVLDD VDNVDQVDAL VGERGWYGEG
SLIIITTRDS EILSKLSVNR QYEVNCLTEM QALKLFSYHS LRKEKPPESL LELSKKMVEM
TGRLPLAVEV FGSSLFDKKG EKEWQAQLEK LKNTQPNDLQ GVLALSFESL DDEEKIVFLD
IACLFLKMEI TKEEVIDVLK GCGYDAEAAL GVLRQKSLVK ILADKDGTLW MHDQIRDMGR
QMVVKESRED PGMRSRLCDR GETMTVLNNM KGTSSIRGIV FDVKKKFVRT PSAVEITSSN
LQNNLSINSM FNYIKSKIVK FPAEEKPKSS EITIPVEPFV PMSKLRLLQI NHVELEGNLK
LLPSELKWLQ WRGCPLKSLP PDFLARQLAV LDLSESGIRR VQSLCSKRVD ENLKVVNLRG
CYNLEDIPDL SNHKALEKLV FQRCNLLVKV PRSVGNLGTL LQLDFRNCSN LAEFLVDVSG
LKRLQKLFLS GCSNLGKLPE SIYRLEKLEK LSLNDCRSIQ ELPLCIGTLT SLEDLYLDGT
ALQSLPSSIG RLKNLQKLHL MHCTAFSKIP ETINTLTSLK ELFINGTAVE ELPLNLGSLS
CLVDFSAGGC KSLKQVPSSI GGLGSLLQLQ LDGTPIETLP GEISHLHFIQ KLELRNCKSL
KFLPESIGGM DTLESLHLEG SNIEELPEDF GKLENLVLLR MNKCKMLKRL PESFGDLKSL
HHLYMEETSV VELPESFGNL SNLRVLKMLK KPLFRSSKSD APGTSEEPRF VIPNSFSNLL
SLEELDARSW GISGKIPDVF EKLSSLRILY LGNNYIHSLP SSLKGLSNLK ELSFSDCREL
TRLPPLPCKL EQLNLANCFS LESISDLSEL TILHELNLTN CDKVDDIPGL EKLTALKRLY
MSGCSSDCSD AVKKRLSKVS LKMLRNLSLP GNRIPEWFSQ GPVTFSSQPN RELRGVIIAV
VVALINHDED EVPDVMGINA QILKPDRLRF NTTLHLSGVP RTSNDQLHIC RYSHHHPMVT
FLEDGFTIQV IKQQLQIKQE VELKMHGIHL VYEGDDDLEA EEDTLNETQL TVSQKLANFF
SSFSEV
//
