ID V4LQT7_EUTSA Unreviewed; 477 AA.
AC V4LQT7;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=GTP cyclohydrolase II domain-containing protein {ECO:0000259|Pfam:PF00925};
GN ORFNames=EUTSA_v10000152mg {ECO:0000313|EMBL:ESQ46154.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ46154.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ46154.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
CC -!- PATHWAY: Cofactor biosynthesis; riboflavin biosynthesis.
CC {ECO:0000256|ARBA:ARBA00005104}.
CC -!- SIMILARITY: In the C-terminal section; belongs to the GTP
CC cyclohydrolase II family. {ECO:0000256|ARBA:ARBA00008976}.
CC -!- SIMILARITY: In the N-terminal section; belongs to the DHBP synthase
CC family. {ECO:0000256|ARBA:ARBA00005520}.
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DR EMBL; KI517426; ESQ46154.1; -; Genomic_DNA.
DR RefSeq; XP_006404701.1; XM_006404638.1.
DR AlphaFoldDB; V4LQT7; -.
DR STRING; 72664.V4LQT7; -.
DR EnsemblPlants; ESQ46154; ESQ46154; EUTSA_v10000152mg.
DR GeneID; 18021715; -.
DR Gramene; ESQ46154; ESQ46154; EUTSA_v10000152mg.
DR KEGG; eus:EUTSA_v10000152mg; -.
DR eggNOG; KOG1284; Eukaryota.
DR OMA; CDSTHLL; -.
DR OrthoDB; 5489599at2759; -.
DR UniPathway; UPA00275; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0009507; C:chloroplast; IEA:EnsemblPlants.
DR GO; GO:0008686; F:3,4-dihydroxy-2-butanone-4-phosphate synthase activity; IEA:EnsemblPlants.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0009231; P:riboflavin biosynthetic process; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.90.870.10; DHBP synthase; 1.
DR Gene3D; 3.40.50.10990; GTP cyclohydrolase II; 1.
DR HAMAP; MF_00180; RibB; 1.
DR InterPro; IPR017945; DHBP_synth_RibB-like_a/b_dom.
DR InterPro; IPR000422; DHBP_synthase_RibB.
DR InterPro; IPR032677; GTP_cyclohydro_II.
DR InterPro; IPR036144; RibA-like_sf.
DR NCBIfam; TIGR00506; ribB; 1.
DR PANTHER; PTHR21327; GTP CYCLOHYDROLASE II-RELATED; 1.
DR PANTHER; PTHR21327:SF41; MONOFUNCTIONAL RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA 2, CHLOROPLASTIC; 1.
DR Pfam; PF00926; DHBP_synthase; 1.
DR Pfam; PF00925; GTP_cyclohydro2; 1.
DR SUPFAM; SSF142695; RibA-like; 1.
DR SUPFAM; SSF55821; YrdC/RibB; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000030689};
KW Riboflavin biosynthesis {ECO:0000256|ARBA:ARBA00022619}.
FT DOMAIN 318..473
FT /note="GTP cyclohydrolase II"
FT /evidence="ECO:0000259|Pfam:PF00925"
SQ SEQUENCE 477 AA; 52536 MW; F227C2921867F10B CRC64;
MKMASLNLRC DSTHLLPCRD VKRSIPLRKT WMCPRIISKR FNVRMGVMSE EGDVFSSSKT
KSNGSMGIET QPDLVSFGTL AAEMIPTTMV SSEVEDEEFD LDRPIDGFAS IPQAIEDIRQ
GKLVIVVDDE DRENEGDLIM AASLVTPEAM AFVVKHGTGI VCVSMKGEDL ERLELPLMVT
RKENEEKLRT AFTVSVDAKR GTSTGVSARD RAQTILSLAS KDSKPQDFNR PGHIFPLRYR
EGGVLKRAGH TEASVDLTVL AGLEPVSVLC EIVDDDGSMA RLPRLRQFAQ ENNLKIISIA
DLIRYRRKRE RLVEFTAVAS IPTMWGPFKA YCFKSLLDGV EHIAMVKGDI GDGKDILVRV
HAECITDDIF GNGSGGKQLA IAMRQIEETG RGVFVYLRGP EANGIDLTHK PRTYDSNSDH
TEGVSFPVAS REYGIGAQIL RDLGVRTMKV MTNNPANYVG LKGYGLSISG KVPLVNP
//
