ID V4M8W2_EUTSA Unreviewed; 620 AA.
AC V4M8W2;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Fatty acyl-CoA reductase {ECO:0000256|RuleBase:RU363097};
DE EC=1.2.1.84 {ECO:0000256|RuleBase:RU363097};
GN ORFNames=EUTSA_v10020305mg {ECO:0000313|EMBL:ESQ48838.1};
OS Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ48838.1, ECO:0000313|Proteomes:UP000030689};
RN [1] {ECO:0000313|EMBL:ESQ48838.1, ECO:0000313|Proteomes:UP000030689}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA Mitchell-Olds T., Schumaker K.S., Wang X.;
RT "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL Front. Plant Sci. 4:46-46(2013).
CC -!- FUNCTION: Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.
CC {ECO:0000256|RuleBase:RU363097}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a long-chain fatty acyl-CoA + 2 H(+) + 2 NADPH = a long-chain
CC primary fatty alcohol + CoA + 2 NADP(+); Xref=Rhea:RHEA:52716,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:57287, ChEBI:CHEBI:57783,
CC ChEBI:CHEBI:58349, ChEBI:CHEBI:77396, ChEBI:CHEBI:83139; EC=1.2.1.84;
CC Evidence={ECO:0000256|RuleBase:RU363097};
CC -!- SIMILARITY: Belongs to the fatty acyl-CoA reductase family.
CC {ECO:0000256|ARBA:ARBA00005928, ECO:0000256|RuleBase:RU363097}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KI517408; ESQ48838.1; -; Genomic_DNA.
DR RefSeq; XP_006407385.1; XM_006407322.1.
DR AlphaFoldDB; V4M8W2; -.
DR STRING; 72664.V4M8W2; -.
DR EnsemblPlants; ESQ48838; ESQ48838; EUTSA_v10020305mg.
DR Gramene; ESQ48838; ESQ48838; EUTSA_v10020305mg.
DR KEGG; eus:EUTSA_v10020305mg; -.
DR eggNOG; KOG1221; Eukaryota.
DR OMA; GMSSCVN; -.
DR Proteomes; UP000030689; Unassembled WGS sequence.
DR GO; GO:0009507; C:chloroplast; IEA:EnsemblPlants.
DR GO; GO:0102965; F:alcohol-forming long-chain fatty acyl-CoA reductase activity; IEA:UniProtKB-EC.
DR GO; GO:0080019; F:alcohol-forming very long-chain fatty acyl-CoA reductase activity; IEA:EnsemblPlants.
DR GO; GO:1903175; P:fatty alcohol biosynthetic process; IEA:EnsemblPlants.
DR GO; GO:0009556; P:microsporogenesis; IEA:EnsemblPlants.
DR GO; GO:0010584; P:pollen exine formation; IEA:EnsemblPlants.
DR GO; GO:0009635; P:response to herbicide; IEA:EnsemblPlants.
DR CDD; cd05236; FAR-N_SDR_e; 1.
DR CDD; cd09071; FAR_C; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR026055; FAR.
DR InterPro; IPR033640; FAR_C.
DR InterPro; IPR013120; Far_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11011:SF45; FATTY ACYL-COA REDUCTASE; 1.
DR PANTHER; PTHR11011; MALE STERILITY PROTEIN 2-RELATED; 1.
DR Pfam; PF07993; NAD_binding_4; 1.
DR Pfam; PF03015; Sterile; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516,
KW ECO:0000256|RuleBase:RU363097};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU363097}; NADP {ECO:0000256|RuleBase:RU363097};
KW Oxidoreductase {ECO:0000256|RuleBase:RU363097};
KW Reference proteome {ECO:0000313|Proteomes:UP000030689}.
FT DOMAIN 138..441
FT /note="Thioester reductase (TE)"
FT /evidence="ECO:0000259|Pfam:PF07993"
FT DOMAIN 546..617
FT /note="Fatty acyl-CoA reductase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03015"
FT REGION 44..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 620 AA; 68572 MW; 42FF255F7CA5FC00 CRC64;
MEALFLSSSS SSIAASNKLA RLHNRRDWSS LVWDKKRVGP TWCRVGGGGG DGGGGRNSKP
ERPIRVSSLL TDRGQVLIRE QSSPAMEAET LVLSPNGNGR AIDINGATTL MPFNGAAMVG
MKEGLGIISF LQGKKFLITG STGFLAKVLI EKVLRIAPDV GKIYLLIKAK NKEAAIERLK
NEVLDAELFN TLRETHGASY QSFMLDKLIP VTGNICDSNI GLEADSAEEI AKDVDVIINS
AANTTFNERY DVALDINTRG PGNLMGFAKK CKKLKLFLQV STAYVNGQRQ GRIMEKPFSM
GECIATENFL EGNRKALDVD REMKLALDAT RKGTQDQEEA QKMKDLGLER ARSYGWQDTY
VFTKAMGEMM INSTRGDVPV VIIRPSVIES TYKDPFPGWM EGNRMMDPIV LCYGKGQLTG
FLVDPKGVLD VVPADMVVNA TLAAIAKHGM ATSDPKPEIN VYQIASSAIN PLVFEDLAEL
LYNHYKSTPC VDSKGDPIMV RLMKLFNSVD DFSDHLWRDA QERSGLMNGV SSAADSKMLQ
KLKFICKKSV EQAKHLATIY EPYTFYGGRF DNSNTQRLME NMSEEEKREF GFDVGSINWK
DYITNVHIPG LRRHVLKGRA
//
