ID   V4MQM0_EUTSA            Unreviewed;       810 AA.
AC   V4MQM0;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   24-JAN-2024, entry version 32.
DE   RecName: Full=TIR domain-containing protein {ECO:0000259|PROSITE:PS50104};
GN   ORFNames=EUTSA_v10024441mg {ECO:0000313|EMBL:ESQ55423.1};
OS   Eutrema salsugineum (Saltwater cress) (Sisymbrium salsugineum).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Eutremeae; Eutrema.
OX   NCBI_TaxID=72664 {ECO:0000313|EMBL:ESQ55423.1, ECO:0000313|Proteomes:UP000030689};
RN   [1] {ECO:0000313|EMBL:ESQ55423.1, ECO:0000313|Proteomes:UP000030689}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23518688; DOI=10.3389/fpls.2013.00046;
RA   Yang R., Jarvis D.E., Chen H., Beilstein M.A., Grimwood J., Jenkins J.,
RA   Shu S., Prochnik S., Xin M., Ma C., Schmutz J., Wing R.A.,
RA   Mitchell-Olds T., Schumaker K.S., Wang X.;
RT   "The Reference Genome of the Halophytic Plant Eutrema salsugineum.";
RL   Front. Plant Sci. 4:46-46(2013).
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DR   EMBL; KI517384; ESQ55423.1; -; Genomic_DNA.
DR   RefSeq; XP_006413970.1; XM_006413907.1.
DR   AlphaFoldDB; V4MQM0; -.
DR   STRING; 72664.V4MQM0; -.
DR   EnsemblPlants; ESQ55423; ESQ55423; EUTSA_v10024441mg.
DR   GeneID; 18029583; -.
DR   Gramene; ESQ55423; ESQ55423; EUTSA_v10024441mg.
DR   KEGG; eus:EUTSA_v10024441mg; -.
DR   eggNOG; ENOG502SI7S; Eukaryota.
DR   OMA; HILECME; -.
DR   OrthoDB; 680547at2759; -.
DR   Proteomes; UP000030689; Unassembled WGS sequence.
DR   GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR   GO; GO:0006952; P:defense response; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   Gene3D; 1.10.8.430; Helical domain of apoptotic protease-activating factors; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 2.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   InterPro; IPR042197; Apaf_helical.
DR   InterPro; IPR044974; Disease_R_plants.
DR   InterPro; IPR011713; Leu-rich_rpt_3.
DR   InterPro; IPR032675; LRR_dom_sf.
DR   InterPro; IPR002182; NB-ARC.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   InterPro; IPR036390; WH_DNA-bd_sf.
DR   PANTHER; PTHR11017:SF552; DISEASE RESISTANCE PROTEIN RPP2B; 1.
DR   PANTHER; PTHR11017; LEUCINE-RICH REPEAT-CONTAINING PROTEIN; 1.
DR   Pfam; PF07725; LRR_3; 1.
DR   Pfam; PF00931; NB-ARC; 1.
DR   Pfam; PF01582; TIR; 1.
DR   PRINTS; PR00364; DISEASERSIST.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF52058; L domain-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000030689}.
FT   DOMAIN          10..176
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   810 AA;  94066 MW;  8DC76E51C7497DC8 CRC64;
     MAFSSSSSKR QFDVFLSFRG ADTRNNFTDH LRQCLRRKSI DAFFDEKLRR GQDISVLFER
     IEQSKMSIVV FSENYANSSW CLDELWKILQ CREKSGHEVI PIFYKVKKSD VENQKGSFGA
     PFQSPMEIFK EDEQEKIGTW RESLRTASNI LGFVYHEDIS ETKFLDDIAK ETLKMLKKLS
     PCDFKGFPGI ELRSKELEDL LMFNNDECVR TIGVLGMTGI GKTLVTEIVY KRNSGQFDGY
     HFVDDVDEEL KWHQLPRLKE KLVRKLSDDE NLDVRALGTR ERYLPNKKLF IVVDNVTDGD
     QIEALIGAKE LYRKGTRIVI ITRDKKLLEN QADATYVVPR LNDREAMELF CLKAFPGNLY
     PPEEFMDLSN KFVDYSKGHP SALKLLGSGL LKKDKLYWTK TWERLIDRPD KEIQRVLEKS
     LNKLGRVQKN IFLDIACFFR SERKDFVSSI LKEYHEDAAT VIEVLENKCL VTISYDRIEM
     HDLLHIMGKY IESITKVHKR SRFWNHKEIC QILERNKGTD SVRGIFLNMS GVERIKLSAD
     AFMRMSNLRF LKFHSSQWCD NDLKFQFCKG IDHFPDKIVY LHWQGYPYDY LPSEFNAEEL
     VDLNLRHSHI KKLWKEEKNT ENLRWVDLSQ SKGLLNLSGL SEAKNLERLD LEGCTSLAAL
     GPEIEQMNKL IYLNLRECTS LKSLPEGINL ESLKTLILSG CSNLQDFHII SEKIEFLYLE
     GSAIERVVES IESLRNLILL NLKNCRNLRN LPNDLCKLKS LQKLILSGCS ALESFPPIEE
     EMKCLEILLM DRTSIKQIPD TICLSNLKIS
//