ID V4PZ12_9CAUL Unreviewed; 572 AA.
AC V4PZ12;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Sodium:proton antiporter {ECO:0000313|EMBL:ESQ92654.1};
GN ORFNames=ABENE_07490 {ECO:0000313|EMBL:ESQ92654.1};
OS Asticcacaulis benevestitus DSM 16100 = ATCC BAA-896.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Caulobacterales;
OC Caulobacteraceae; Asticcacaulis.
OX NCBI_TaxID=1121022 {ECO:0000313|EMBL:ESQ92654.1, ECO:0000313|Proteomes:UP000017837};
RN [1] {ECO:0000313|EMBL:ESQ92654.1, ECO:0000313|Proteomes:UP000017837}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 16100 {ECO:0000313|EMBL:ESQ92654.1,
RC ECO:0000313|Proteomes:UP000017837};
RX PubMed=24463524; DOI=10.1038/nature12900;
RA Jiang C., Brown P.J., Ducret A., Brun Y.V.;
RT "Sequential evolution of bacterial morphology by co-option of a
RT developmental regulator.";
RL Nature 506:489-493(2014).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the monovalent cation:proton antiporter 2 (CPA2)
CC transporter (TC 2.A.37) family. {ECO:0000256|ARBA:ARBA00005551}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ESQ92654.1}.
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DR EMBL; AWGB01000011; ESQ92654.1; -; Genomic_DNA.
DR RefSeq; WP_018082554.1; NZ_AWGB01000011.1.
DR AlphaFoldDB; V4PZ12; -.
DR STRING; 1121022.GCA_000376105_02888; -.
DR PATRIC; fig|1121022.4.peg.1500; -.
DR eggNOG; COG1226; Bacteria.
DR eggNOG; COG4651; Bacteria.
DR OrthoDB; 9781411at2; -.
DR Proteomes; UP000017837; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015297; F:antiporter activity; IEA:InterPro.
DR GO; GO:0006813; P:potassium ion transport; IEA:InterPro.
DR GO; GO:1902600; P:proton transmembrane transport; IEA:InterPro.
DR Gene3D; 1.20.1530.20; -; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR006153; Cation/H_exchanger.
DR InterPro; IPR038770; Na+/solute_symporter_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR003148; RCK_N.
DR PANTHER; PTHR42751:SF1; CATION_PROTON ANTIPORTER YBAL-RELATED; 1.
DR PANTHER; PTHR42751; SODIUM/HYDROGEN EXCHANGER FAMILY/TRKA DOMAIN PROTEIN; 1.
DR Pfam; PF00999; Na_H_Exchanger; 1.
DR Pfam; PF02254; TrkA_N; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS51201; RCK_N; 1.
PE 3: Inferred from homology;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000017837};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 6..26
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 33..51
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..77
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 89..110
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 116..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..171
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 233..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 286..304
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 311..333
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 339..367
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 374..393
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 432..554
FT /note="RCK N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51201"
SQ SEQUENCE 572 AA; 60889 MW; 4B446FC41D48BF98 CRC64;
MEHHNISLIT TLASGFGLAL VFGFLAEKIK LPALIGYLFA GILIGPATPG FVADTNIAAQ
LSEIGVMLLM FGVGLHFSLA DLMSVKRIAL PGAIVQMSLA TLLGMALAMW GWGWNFGAAL
VFGVSLSCAS TVVLLKALEA RKAVDSINGR IAVGWLVVED LVTVLVLVLL PPLAQLLGAT
GGTGQAFTGN LWVEIGKTLL SVGAFIALML LVGRRALPWI LLQVARTGTR ELFTLAVIAA
AITIAWCASE MFSVSFALGA FFAGMVMRES KFSHRAAEES LPLRDAFSVL FFVSVGMLFN
PMVLVEKPLE VLAVVGIIIF GKGVAAAALA LILRYPLNTA LTVAAGLAQI GEFSFILGGL
GVSLGVLPQE GMNLLLAGAL ISIALNPFVF KAIEPASAWV LKHSSLARAH ERSDDVLAVL
PDTTADKYLS GQVIVVGFGR VGKWLAESLD AQGIAYVVVE ESRDRVEELR AQGKAAVFGN
ATQSDVLIQA HIATAAMLVV ATPDLINISQ MVDTARRINP AVEVVLRTHS QDEVDFLRRE
KMGEVFFGEE ELAKNILDHI RKRFDTPVMA HA
//
