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Database: UniProt
Entry: V4QSK2_STRIN
LinkDB: V4QSK2_STRIN
Original site: V4QSK2_STRIN 
ID   V4QSK2_STRIN            Unreviewed;       451 AA.
AC   V4QSK2;
DT   22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT   22-JAN-2014, sequence version 1.
DT   25-OCT-2017, entry version 31.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=IUSA1_02450 {ECO:0000313|EMBL:ESR10274.1};
OS   Streptococcus iniae IUSA1.
OC   Bacteria; Firmicutes; Bacilli; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=1273539 {ECO:0000313|EMBL:ESR10274.1, ECO:0000313|Proteomes:UP000017720};
RN   [1] {ECO:0000313|EMBL:ESR10274.1, ECO:0000313|Proteomes:UP000017720}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=IUSA1 {ECO:0000313|EMBL:ESR10274.1};
RX   PubMed=23516181;
RA   El Aamri F., Acosta F., Real F., Padilla D.;
RT   "Whole-Genome Sequence of the Fish Virulent Strain Streptococcus iniae
RT   IUSA-1, Isolated from Gilthead Sea Bream (Sparus aurata) and Red Porgy
RT   (Pagrus pagrus).";
RL   Genome Announc. 1:E0002513-E0002513(2013).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00735475}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:ESR10274.1}.
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DR   EMBL; AOCT02000011; ESR10274.1; -; Genomic_DNA.
DR   RefSeq; WP_003100539.1; NZ_AOCT02000011.1.
DR   EnsemblBacteria; ESR10274; ESR10274; IUSA1_02450.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000017720; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000017720};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000017720}.
FT   DOMAIN      144    277       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      360    429       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     152    159       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   451 AA;  51767 MW;  16D5163F93549A9C CRC64;
     MTENEQIFWN RVLELAQNQL TQATYEFFVF DARLVKVENQ VATIYLESVK QLFWENNLKD
     VILTAGFEIY NAQISIEYVF EDYLEESQPA QSNTQVFSRQ PVNPLPIVAS DLNSKYNFEN
     FIQGDENRWA VAASIAVANT PGTTYNPLFI WGGPGLGKTH LLNAIGNSVL RDNPNARIKY
     ITAENFINEF VIHIRLDTMD ELKEKFRNLD LLLIDDIQSL AKKTLSGTQE EFFNTFNALH
     NNNKQIVLTS DRTPDHLNDL EERLVTRFKW GLTVNITPPD FETRVAILTN KIQEYNFTFP
     QDTIEYLAGQ FDSNVRDLEG ALKDISLVAN FKQIDRITVD VAAEAIRARK QDTPKMTIIP
     IEEIQIQVGK FYDVTVKEIK ATKRTQDIVL ARQVAMFLAR EMTDNSLPKI GKEFGGRDHS
     TVLHAYNKIK NMIAEDESLR IEIETIKNKI K
//
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