ID V4XMN1_9ARCH Unreviewed; 524 AA.
AC V4XMN1;
DT 22-JAN-2014, integrated into UniProtKB/TrEMBL.
DT 22-JAN-2014, sequence version 1.
DT 24-JAN-2024, entry version 35.
DE RecName: Full=histidine kinase {ECO:0000256|ARBA:ARBA00012438};
DE EC=2.7.13.3 {ECO:0000256|ARBA:ARBA00012438};
GN ORFNames=A07HR67_01653 {ECO:0000313|EMBL:ESS03258.1};
OS uncultured archaeon A07HR67.
OC Archaea; environmental samples.
OX NCBI_TaxID=1412871 {ECO:0000313|EMBL:ESS03258.1, ECO:0000313|Proteomes:UP000030660};
RN [1] {ECO:0000313|Proteomes:UP000030660}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=24335829;
RA Podell S., Emerson J.B., Jones C.M., Ugalde J.A., Welch S.,
RA Heidelberg K.B., Banfield J.F., Allen E.E.;
RT "Seasonal fluctuations in ionic concentrations drive microbial succession
RT in a hypersaline lake community.";
RL ISME J. 0:0-0(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + protein L-histidine = ADP + protein N-phospho-L-
CC histidine.; EC=2.7.13.3; Evidence={ECO:0000256|ARBA:ARBA00000085};
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DR EMBL; KI543167; ESS03258.1; -; Genomic_DNA.
DR AlphaFoldDB; V4XMN1; -.
DR STRING; 1412871.A07HR67_01653; -.
DR PATRIC; fig|1412871.3.peg.1728; -.
DR Proteomes; UP000030660; Unassembled WGS sequence.
DR GO; GO:0000155; F:phosphorelay sensor kinase activity; IEA:InterPro.
DR CDD; cd00082; HisKA; 1.
DR Gene3D; 1.10.287.130; -; 1.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.450.20; PAS domain; 1.
DR InterPro; IPR003018; GAF.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR003594; HATPase_C.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR005467; His_kinase_dom.
DR InterPro; IPR003661; HisK_dim/P.
DR InterPro; IPR036097; HisK_dim/P_sf.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR PANTHER; PTHR43711:SF1; HISTIDINE KINASE 1; 1.
DR PANTHER; PTHR43711; TWO-COMPONENT HISTIDINE KINASE; 1.
DR Pfam; PF13185; GAF_2; 1.
DR Pfam; PF02518; HATPase_c; 1.
DR Pfam; PF00512; HisKA; 1.
DR SMART; SM00065; GAF; 1.
DR SMART; SM00387; HATPase_c; 1.
DR SMART; SM00388; HisKA; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF47384; Homodimeric domain of signal transducing histidine kinase; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 1.
DR PROSITE; PS50109; HIS_KIN; 1.
DR PROSITE; PS50112; PAS; 1.
PE 4: Predicted;
KW Kinase {ECO:0000313|EMBL:ESS03258.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030660};
KW Transferase {ECO:0000313|EMBL:ESS03258.1}.
FT DOMAIN 9..52
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 328..517
FT /note="Histidine kinase"
FT /evidence="ECO:0000259|PROSITE:PS50109"
FT REGION 56..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 524 AA; 56970 MW; 4AD7AB694A04CE44 CRC64;
MVPDAADPLD AVSDVTFVVD GSGDVQIASG RAESVFGRRR EALAGRAIDE LLVTSAESKP
AADAPPVGGD DAARRDTDAD GFSWTRYLDD PEPVSLTDGL DLYARRADDT TSLVRLGLTP
VPHEDGVSVV ATAVDLSRER TRTARLHRQT ETLASLHHAT QELLTKTDTE NAAETAVEYI
DDVVGFSIAA IWLYDEDRDA LEPVGWTDTA GNLFDTHPTY AADDEALSWE AFESGEPRYV
PDVHDEADRY NAETPIRSEL IVPLGRYGVL NIGSTEPNAL DADDRTIARL WGASVTMVFV
RIERERQLRE READIARERD RLEEFAGLVS HDLRTPLNVA QGHLEMVRAE TDNEKLETAA
AALDRMEALI ADLLTLARHG EVVDDDEAVS LPTLVEEVGV TVGMETTQLT VADVTALADR
SRLAQLFENL LGNARRHAGD DVRVTVGVLD DGEGFYVADD GPGIDAERRE GVFEAGHTSV
ADGTGFGLKI VSEIAEAHGW SVDLVESDEG GARFEFRGVE LVRE
//
